Results 81 to 90 of about 10,504 (228)

Molecular docking‐guided in‐depth investigation of the biological activities and phytochemical and mineral profiles of endemic Phlomis capitata

Journal of the Science of Food and Agriculture, Volume 105, Issue 7, Page 3760-3775, May 2025.
Abstract BACKGROUND Phlomis capitata is an endemic species of flowering aromatic and medicinal plant in the family Lamiaceae, native to regions of the Mediterranean and nearby areas. Understanding the chemical compounds present in P. capitata can reveal potential medicinal properties.
Ebubekir İzol
wiley   +1 more source

Synthesis of Benzimidazole–Based Analogs as Anti Alzheimer’s Disease Compounds and Their Molecular Docking Studies

Molecules, 2020
We synthesized 10 analogs of benzimidazole-based thiosemicarbazide 1 (a–j) and 13 benzimidazole-based Schiff bases 2 (a–m), and characterized by various spectroscopic techniques and evaluated in vitro for acetylcholinesterase (AchE) and ...
Bushra Adalat, Fazal Rahim, Muhammad Taha, Foziah J. Alshamrani, El Hassane Anouar, Nizam Uddin, Syed Adnan Ali Shah, Zarshad Ali, Zainul Amiruddin Zakaria   +8 more
doaj   +1 more source

Investigation of Thiazolidine‐2,4‐Dione Derivatives as Acetylcholinesterase Inhibitors: Synthesis, In Vitro Biological Activities and In Silico Studies

ChemistryOpen, Volume 14, Issue 5, May 2025.
Thiazolidin‐2,4‐dion derivatives were synthesized and evaluated for drug‐likeness, BBB permeability, and ADMET properties. Docking studies revealed that all derivatives (CHT1‐5) had good AChE inhibition, although CHT1 was the most effective and showed strong antioxidant activity in vitro.
Hanane Naeimi, Maryam Taheri, Hossein Ghafouri, Asadollah Mohammadi   +3 more
wiley   +1 more source

In Vitro, Anti‐Colon Cancer Activity of Green Dumbbell‐Shaped Rhododendron luteum‐Based Carbon Dots

ChemistryOpen, Volume 14, Issue 5, May 2025.
The anticancer potential of Rhododendron luteum‐based carbon dots was investigated. Environmentally friendly synthesis yielded carbon dots that selectively induced cytotoxicity in HCT116 cells by reducing CD44/24 ratio, causing G2/M phase arrest, and enhancing apoptosis.
Alper Durmaz, İbrahim Mizan Kahyaoğlu, Erdi Can Aytar, Ferdane Danışman Kalındemirtaş, Esra Sert, Ayşe Erol‐Bozkurt, Selcan Karakuş   +6 more
wiley   +1 more source

Inhibition of Butyrylcholinesterase by Phenothiazine Derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2002
The inhibition of horse serum butyrylcholinesterase (EC 3.1.1.8) by 10 phenothiazine or thioxanthene derivatives was studied with a purified enzyme. Most compounds were mixed inhibitors, but for some of them an apparent competitive inhibition was observed. The competitive inhibition constants (K) were in the range 0.05 to 5 microM.
Jean Debord, Thierry Dantoine, Jean-Claude Bollinger, Louis Merle   +3 more
openaire   +3 more sources

Novel pyridazinone derivatives as butyrylcholinesterase inhibitors

Bioorganic Chemistry, 2019
In the current study, forty-four new [3-(2/3/4-methoxyphenyl)-6-oxopyridazin-1(6H)-yl]methyl carbamate derivatives were synthesized and evaluated for their ability to inhibit electric eel acetylcholinesterase (EeAChE) and equine butyrylcholinesterase (eqBuChE) enzymes.
Dundar, Yasemin, Kuyrukcu, Ozge, Eren, Gokcen, Deniz, F. Sezer Senol, Onkol, Tijen, Orhan, Ilkay Erdogan   +5 more
openaire   +5 more sources

Eine Mikromethode zur gleichzeitigen Bestimmung der Acetylcholinesterase und der Butyrylcholinesterase im Säugetierblut [PDF]

, 1969
Ronald Zech, Knut Franke, G. F. Domagk
openalex   +1 more source

Electron microscope localization of acetylcholinesterase and butyrylcholinesterase in the superior cervical ganglion of the cat. I. Normal ganglion. [PDF]

, 1978
Richard W. Davis, George B. Koelle
openalex   +1 more source

A steady-state kinetic model of butyrylcholinesterase from horse plasma [PDF]

, 1974
Klas‐Bertil Augustinsson, Tamás Bartfai, Bengt Mannervik   +2 more
openalex   +1 more source

Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson’s disease dementia

Clinical Interventions in Aging, 2017
Nagaendran Kandiah,1,2 Ming-Chyi Pai,3,4 Vorapun Senanarong,5 Irene Looi,6,7 Encarnita Ampil,8 Kyung Won Park,9 Ananda Krishna Karanam,10 Stephen Christopher11 1Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, 2Duke-NUS,
Kandiah N, Pai MC, Senanarong V, Looi I, Ampil E, Park KW, Karanam AK, Christopher S   +7 more
doaj