Results 81 to 90 of about 105,811 (251)

N,N- and N,O-Bidentate-Chelation-Assisted Alkenyl C–H Functionalization

Molecules
Chelation-assisted olefinic C–H functionalization has been demonstrated to be a powerful method of constructing multi-substituted alkenes from simpler ones.
Yawei Zhang, Chengxing Peng, Xiaoli Li, Xiuying Liu, Liyuan Ding, Guofu Zhong, Jian Zhang   +6 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Enantioselective functionalization of unactivated C(sp3)–H bonds through copper-catalyzed diyne cyclization by kinetic resolution

Nature Communications
Site- and stereoselective C–H functionalization is highly challenging in the synthetic chemistry community. Although the chemistry of vinyl cations has been vigorously studied in C(sp3)–H functionalization reactions, the catalytic enantioselective C(sp3)–
Yang-Bo Chen, Li-Gao Liu, Zhe-Qi Wang, Rong Chang, Xin Lu, Bo Zhou, Long-Wu Ye   +6 more
doaj   +1 more source

C–H Activation via Group 8–10 Pincer Complexes: A Mechanistic Approach

Inorganics
C–H bond activation is a crucial synthetic strategy widely utilized in both academic and industrial settings. Due to the strong and kinetically inert nature of the C–H bond, its functionalization typically requires metal-based catalysts.
Juan S. Serrano-García, Andrés Amaya-Flórez, Jordi R.-Galindo, Lucero González-Sebastián, Luis Humberto Delgado-Rangel, David Morales-Morales   +5 more
doaj   +1 more source

Functionalization of carbon nanotubes with -CHn, -NHn fragments, -COOH and -OH groups

, 2013
We present results of extensive theoretical studies concerning stability, morphology, and band structure of single wall carbon nanotubes (CNTs) covalently functionalized by -CHn(for n=2,3,4),-NHn(for n=1,2,3,4),-COOH and -OH groups. Our studies are based
Majewski, Jacek A., Milowska, Karolina Z.   +1 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Designing all-graphene nanojunctions by covalent functionalization

, 2011
We investigated theoretically the effect of covalent edge functionalization, with organic functional groups, on the electronic properties of graphene nanostructures and nano-junctions.
Abe S., Alice Ruini, Barone V., Bekyarova E., Burghard M., Cai J., Caldas M. J., Campos L. C., Cano-Márquez A. G., Castro Neto A. H., Caterina Cocchi, Chen W., Chen Z., Datta S. S., Deborah Prezzi, Dewar M. J. S., Dávila L. Y. A., Elisa Molinari, Farmer D. B., Farmer D. B., Geim A., Han M. Y., Hantal G., Jia X., Jiao L., Kosynkin D. V., Lair S., Li X., Loh K., Lohmann T., Lopez-Bezanilla A., Lu Y. H., Marilia J. Caldas, Nakada K., Novoselov K. S., Ponomarenko L., Prezzi D., Prezzi D., Qian H., Roothaan C. C. J., Sevinçli H., Sinitskii A., Soldano C., Son Y.-W., Sun J. T., Tachikawa H., Venkataraman L., Wang X., Wang X., Wang X., Wetmore S. D., Xia F., Yang L., Yang L., Yang X., Zhang Y.-H.   +55 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source