Iridium-Catalyzed Silylation of Five-Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl-Imidazoline Ligand. [PDF]
, 2020 The steric effects of substituents on five-membered rings are less pronounced than those on six-membered rings because of the difference in bond angles. Thus, the regioselectivities of reactions of five-membered heteroarenes that occur with selectivities
Hartwig, John F +3 more
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When metal-catalyzed C–H functionalization meets visible-light photocatalysis
Beilstein Journal of Organic Chemistry, 2020 While aiming at sustainable organic synthesis, over the last decade particular attention has been focused on two modern fields, C–H bond activation, and visible-light-induced photocatalysis.
Lucas Guillemard, Joanna Wencel-Delord
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Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp3)−H Bonds [PDF]
, 2015 The transition-metal-catalyzed direct C–H bond fluorination is an attractive synthetic tool toward the preparation of organofluorines. While many methods exist for the direct sp3 C–H functionalization, site-selective fluorination of unactivated sp3 ...
Ge, Haibo +3 more
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Photoredox C–H functionalization leads the site-selective phenylalanine bioconjugation
Scientific Reports, 2022 Site-selectively chemical bioconjugation of peptides and proteins can improve the therapeutic exploration of modified protein drugs. Only 3.8% natural abundance of phenylalanine in protein and nearly 90% of proteins contain at least one phenylalanine ...
Yue Weng +3 more
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Iridium-Catalyzed, β-Selective C(sp3)-H Silylation of Aliphatic Amines To Form Silapyrrolidines and 1,2-Amino Alcohols. [PDF]
, 2018 The functionalization of unactivated C(sp3)-H bonds of aliphatic amines catalyzed by transition-metal complexes is important because amine-based functionality is present in a majority of biologically active molecules and commercial pharmaceuticals ...
Hartwig, John F, Lee, Taegyo, Su, Bo
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Metal-free sp(3) C-H functionalization: a novel approach for the syntheses of selenide ethers and thioesters from methyl arenes [PDF]
, 2014 A DTBP-promoted metal-free and solvent-free formation of C-Se and C-S bonds through sp(3) C-H functionalization of methyl arenes with diselenides and disulfides is ...
Badsara, Satpal Singh +6 more
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Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization
Green Synthesis and Catalysis, 2023 C–H late-stage functionalization has gradually become a powerful approach for the rapid optimization of lead compounds’ bioactivity. Significant advances in this field have been achieved in the past few years, mainly, the C–H functionalization system in (
Weidong Shang +3 more
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Site-Selective C−H Arylation of Primary Aliphatic Amines Enabled by a Catalytic Transient Directing Group [PDF]
, 2016 Transition-metal-catalysed direct C–H bond functionalization of aliphatic amines is of great importance in organic and medicinal chemistry research. Several methods have been developed for the direct sp3 C–H functionalization of secondary and tertiary ...
Ge, Haibo, Liu, Yongbing
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Transition-metal-free electrochemical-induced active C(sp3)-H functionalization
Green Chemistry Letters and Reviews, 2023 Direct C–H bond functionalization is the most effective technique to construct C–X (X = C, N, O, S, etc.), which could simplify the conventional synthesis methods.
Xiaolong Ma +4 more
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RhI/RhIII catalyst-controlled divergent aryl/heteroaryl C-H bond functionalization of picolinamides with alkynes [PDF]
, 2015 The ability to establish switchable site-selectivity through catalyst control in the direct functionalization of molecules that contain distinct C-H bonds remains a demanding challenge that would enable the construction of diverse scaffolds from the same
Alonso, Inés +5 more
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