Results 121 to 130 of about 459,122 (273)

Biomaterials‐based nanoparticles conjugated to regulatory T cells provide a modular system for localized delivery of pharmacotherapeutic agents

Journal of Biomedical Materials Research Part A, Volume 111, Issue 2, Page 185-197, February 2023., 2023
Abstract Type 1 diabetes (T1D) presents with two therapeutic challenges: the need to correct underlying autoimmunity and restore β‐cell mass. We harnessed the unique capacity of regulatory T cells (Tregs) and the T cell receptor (TCR) to direct tolerance induction along with tissue‐localized delivery of therapeutic agents to restore endogenous β‐cell ...
Gregory P. Marshall, Judit Cserny, Chun‐Wei Wang, Benjamin Looney, Amanda L. Posgai, Rhonda Bacher, Benjamin Keselowsky, Todd M. Brusko   +7 more
wiley   +1 more source

Fresh insights into the light‐induced pineal gland circadian rhythm transmission mechanism derived from mRNA and miRNA profiling

Animal Research and One Health, EarlyView.
Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li, Yanyan Sun, Jingwei Yuan, Xiangchen Li, Lei Shi, Adamu Mani Isa, Yuanmei Wang, Pingzhuang Ge, Yunhe Zong, Panlin Wang, Jilan Chen   +10 more
wiley   +1 more source

Systematic review on spheroids from adipose‐derived stem cells: Spontaneous or artefact state?

Journal of Cellular Physiology, Volume 237, Issue 12, Page 4397-4411, December 2022., 2022
Our proposed model of spheroid isolation from liposuction fat. The tissue disintegration releases the pre‐existing spheroids as intact structures. This could be the ideal technique to culture cells in suspension because it avoids a preliminary adhesion isolation step and thus an upstream cell selection.
Anna Barbara Di Stefano, Valentina Urrata, Marco Trapani, Francesco Moschella, Adriana Cordova, Francesca Toia   +5 more
wiley   +1 more source

Integration of the Second Messenger c-di-GMP into the Chemotactic Signaling Pathway [PDF]

, 2013
Matthew H. Russell, Amber N. Bible, Xin Fang, Jessica Gooding, Shawn R. Campagna, Mark Gomelsky, Gladys Alexandre   +6 more
openalex   +1 more source

Endogenous Retroelement Activation is Implicated in Interferon‐α Production and Anti–Cyclic Citrullinated Peptide Autoantibody Generation in Early Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Endogenous retroelements (EREs) stimulate type 1 interferon (IFN‐I) production but have not been explored as potential interferonogenic triggers in rheumatoid arthritis (RA). We investigated ERE expression in early RA (eRA), a period in which IFN‐I levels are increased.
Faye A. H. Cooles, Gemma Vidal Pedrola, Najib Naamane, Arthur G. Pratt, Ben Barron‐Millar, Amy E. Anderson, Catharien M. U. Hilkens, John Casement, Vincent Bondet, Darragh Duffy, Fan Zhang, Ruchi Shukla, John D. Isaacs   +12 more
wiley   +1 more source

Multiple Use of Regenerated Depth Filters in Antibody Purification Processes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT During the manufacturing of therapeutic antibodies, disposable depth filters are used after affinity chromatography to remove haze and process‐related impurities such as host cell proteins (HCP) and DNA known as critical quality attributes.
Bernhard Spensberger, Ferdinand Stueckler, Marc Pompiati, Christoph Feistl, Thorsten Lemm, Roberto Falkenstein   +5 more
wiley   +1 more source

Faculty Opinions recommendation of Cyclic diguanylate (c-di-GMP) regulates Vibrio cholerae biofilm formation.

, 2004
Drusilla Burns
openalex   +2 more sources

Bayesian Optimization in Bioprocess Engineering—Where Do We Stand Today?

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Bayesian optimization is a stochastic, global black‐box optimization algorithm. By combining Machine Learning with decision‐making, the algorithm can optimally utilize information gained during experimentation to plan further experiments—while balancing exploration and exploitation.
Florian Gisperg, Robert Klausser, Mohamed Elshazly, Julian Kopp, Eva Přáda Brichtová, Oliver Spadiut   +5 more
wiley   +1 more source

Novel tricks played by the second messenger c-di-GMP in bacterial biofilm formation [PDF]

, 2013
Regine Hengge
openalex   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source