Results 121 to 130 of about 470,032 (357)

Regulation of Protein Secretion Systems Mediated by Cyclic Diguanylate in Plant-Interacting Bacteria [PDF]

, 2019
The ubiquitous second messenger cyclic diguanylate (c-di-GMP) is involved in the regulation of different processes in bacteria. In phytopathogens, intracellular fluctuations in the concentration of this molecule contribute to the lifestyle switching from
López Baena, Francisco Javier, Medina Morillas, Carlos, Vinardell González, José María   +2 more
core   +1 more source

Illuminating New Frontiers: Exploring the Photosensitizing Potential of Passiflora Species in Combating Methicillin‐Resistant Staphylococcus aureus (MRSA) and Their Infection in Senescent Mice

Advanced Biology, EarlyView.
This study investigates the photosensitizing potential of Passiflora cincinnata in Antimicrobial Photodynamic Therapy (aPDT) against skin infection caused by Methicillin‐resistant Staphylococcus aureus (MRSA) in a senescent murine model. The P. cincinnata exhibits antimicrobial activity, with reduced bacterial load, lower leukocyte infiltration, and ...
Caroline Vieira Gonçalves, Maria Poliana Leite Galantini, Igor Pereira Ribeiro Muniz, Paulo Henrique Bispo Lima, Israel Souza Ribeiro, Maria Eduarda Santos de Oliveira, Caio Oliveira Lopes de Magalhães, Maria Elisa Santos Flores, Samara Lopes de Oliveira, Catarina Silva Guimarães, Paulinne Moreira Lima, Luísa Carregosa Santos, Daiana Silva Lopes, Juliano Geraldo Amaral, Robson Amaro Augusto da Silva   +14 more
wiley   +1 more source

A Nutrient-Regulated Cyclic Diguanylate Phosphodiesterase Controls Clostridium difficile Biofilm and Toxin Production During Stationary Phase [PDF]

, 2017
The signaling molecule cyclic diguanylate (c-di-GMP) mediates physiological adaptation to extracellular stimuli in a wide range of bacteria. The complex metabolic pathways governing c-di-GMP synthesis and degradation are highly regulated, but the ...
Cheney, Richard E., Courson, David S., Garrett, Elizabeth M., McBride, Shonna M., McKee, Robert W., Purcell, Erin B., Tamayo, Rita   +6 more
core   +5 more sources

Dysregulation of Cytosolic c-di-GMP in Edwardsiella piscicida Promotes Cellular Non-Canonical Ferroptosis

Frontiers in Cellular and Infection Microbiology, 2022
Programmed cell death plays an important role in modulating host immune defense and pathogen infection. Ferroptosis is a type of inflammatory cell death induced by intracellular iron-dependent accumulation of toxic lipid peroxides.
Y. Wen, Ying C Wang, Shouwen Chen, Xiaoping Zhou, Yuanxing Zhang, Dahai Yang, G. Núñez, Qin Liu   +7 more
semanticscholar   +1 more source

Plasma‐Treated Hydrogel for Combined RONS and Chemotherapy Delivery: A Proof‐of‐Concept In Ovo

Advanced Functional Materials, EarlyView.
This study explores plasma‐treated hydrogels (PTH) as a new way to deliver both reactive oxygen and nitrogen species and chemotherapy (Doxorubicin) directly to tumors. In ovo tests show effects after a single dose, especially in osteosarcoma tumors. Tumor weight decrease, and a resistance‐related protein is reduced.
Milica Živanić, Albert Espona‐Noguera, Angela Privat Maldonado, Patrik Matušů, Francesco Tampieri, Maria‐Pau Ginebra, Abraham Lin, Evelien Smits, Annemie Bogaerts, Cristina Canal   +9 more
wiley   +1 more source

A novel c-di-GMP binding domain in glycosyltransferase BgsA is responsible for the synthesis of a mixed-linkage β-glucan

Scientific Reports, 2017
BgsA is the glycosyltransferase (GT) involved in the synthesis of a linear mixed-linkage β-glucan (MLG), a recently described exopolysaccharide activated by c-di-GMP in Sinorhizobium meliloti and other Rhizobiales.
Daniel Pérez-Mendoza, Daniela Bertinetti, Robin Lorenz, María-Trinidad Gallegos, Friedrich W. Herberg, Juan Sanjuán   +5 more
doaj   +1 more source

The RNA Domain Vc1 Regulates Downstream Gene Expression in Response to Cyclic Diguanylate in Vibrio cholerae. [PDF]

PLoS ONE, 2016
In many bacterial species, including the aquatic bacterium and human pathogen Vibrio cholerae, the second messenger cyclic diguanylate (c-di-GMP) modulates processes such as biofilm formation, motility, and virulence factor production.
Ankunda T Kariisa, Kevin Weeks, Rita Tamayo   +2 more
doaj   +1 more source

Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators [PDF]

, 2017
The flagellar motor is a sophisticated rotary machine facilitating locomotion and signal transduction. Owing to its important role in bacterial behavior, its assembly and activity are tightly regulated. For example, chemotaxis relies on a sensory pathway
Abel, Abel, Aldridge, Aldridge, Altschul, Attmannspacher, Baker, Belas, Berg, Boehm, Bond, Bourret, Bren, Briegel, Burkart, Chen, Chevance, Cho, Chou, Christen, Christen, Christen, Crooks, Davis, Deshpande, Dufour, Ely, Ely, Fang, Ferré, Finn, Galperin, Gao, Girgis, Habazettl, Harshey, Harshey, Hazelbauer, Hoffman, Hug, Jenal, Jenal, Jones, Karimova, Kawagishi, Kojima, Koyasu, Krell, Kulasekara, Lasker, Laventie, Lee, Li, Liu, Lori, Misselwitz, Molaei, Mukherjee, Nesper, Nierman, Parkinson, Paul, Persat, Pilizota, Porter, Porter, Porter, Russell, Sarkar, Scharf, Schneider, Schrader, Segata, Skerker, Sklenár, Smith, Sonnhammer, Sourjik, Steiner, Tindall, UniProt Consortium, Vacic, Volkman, Wang, Welch, Wolfe, Xie, Xu, Zhou, Zhou   +89 more
core   +1 more source

Precise Quantification of Angiogenesis in 3D Biomaterials Using in Vitro CAM Models: Enhancing 3Rs in Research and Minimizing in Vivo Dependency

Advanced Functional Materials, EarlyView.
The study develops elastin–fibrin scaffolds and evaluates angiogenesis using the chorioallantoic membrane (CAM) model. Advanced imaging with confocal microscopy and Indocyanine Green dye enables precise 3D quantification of vascular networks. Findings demonstrate superior microvessel visualization compared to micro‐CT using Microfil and Optiray 350 ...
Ece Melis Er, Martha Patricia Pérez González, Beatriz Gil Garrido, Jasmine Ho, Hae‐Won Kim, Jonathan Campbell Knowles, Jia Hua, Ferdinand Lali, Prasad Sawadkar   +8 more
wiley   +1 more source

Complex Regulatory Pathways Connect Vfm Quorum-sensing and Cyclic-di-GMP Signaling to Bacterial Virulence in the Phytopathogen Dickeya Dadantii 3937 [PDF]

, 2022
The bacterial second messenger Bis-(3’-5’)-cyclic dimeric guanosine monophosphate (c-di-GMP) regulates multiple cellular behaviors in most bacteria. Bacterial c-di-GMP signaling involves enzymes that synthesize and degrade c-di-GMP, c-di-GMP binding ...
Banerjee, Biswarup
core   +1 more source