Results 11 to 20 of about 501,367 (176)

How c-di-GMP controls progression through the Streptomyces life cycle. [PDF]

Curr Opin Microbiol
Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3',
Gallagher KA, Tschowri N, Brennan RG, Schumacher MA, Buttner MJ.   +4 more
europepmc   +2 more sources

AphA-dependent c-di-GMP production in Vibrio parahaemolyticus is mediated by direct regulation of eapA transcription encoding an EAL domain-containing protein [PDF]

Journal of Bacteriology
Vibrio parahaemolyticus, a major seafood-borne pathogen, employs quorum sensing (QS) and c-di-GMP to regulate virulence, motility, and biofilm formation.
Nan Zhang, Wu Xu, Xue Li, Miaomiao Zhang, Xi Luo, Bin Ni, Renfei Lu, Yiquan Zhang   +7 more
doaj   +2 more sources

c-di-GMP inhibits rRNA methylation and impairs ribosome assembly in the presence of kanamycin [PDF]

EMBO Reports
Cyclic diguanosine monophosphate (c-di-GMP) is a ubiquitous bacterial secondary messenger with diverse functions. A previous Escherichia coli proteome microarray identified that c-di-GMP binds to the 23S rRNA methyltransferases RlmI and RlmE.
Siqi Yu, Zheyao Hu, Xiaoting Xu, Xiaoran Liang, Jiayi Shen, Min Liu, Mingxi Lin, Hong Chen, Jordi Marti, Sheng-ce Tao, Zhaowei Xu   +10 more
doaj   +2 more sources

Identification and Characterization of c-di-GMP Metabolic Enzymes of Leptospira interrogans and c-di-GMP Fluctuations After Thermal Shift and Infection [PDF]

Frontiers in Microbiology, 2018
Leptospirosis is a widespread zoonotic disease caused by pathogenic Leptospira species. The most common species, Leptospira interrogans, can transfer from contaminated soil or water to the human body.
Guohui Xiao, Liangliang Kong, Liangliang Kong, Rongbo Che, Yusi Yi, Qinchao Zhang, Jie Yan, Jie Yan, Xu'ai Lin, Xu'ai Lin   +9 more
doaj   +3 more sources

A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa

Nature Communications
Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a bacterial second messenger that modulates various processes including biofilm formation, motility, and host-microbe symbiosis.
Xueliang Zhan, Kuo Zhang, Chenchen Wang, Qiao Fan, Xiujia Tang, Xi Zhang, Ke Wang, Yang Fu, Haihua Liang   +8 more
doaj   +2 more sources

CRP-Like Transcriptional Regulator MrpC Curbs c-di-GMP and 3′,3′-cGAMP Nucleotide Levels during Development in Myxococcus xanthus

mBio, 2022
Myxococcus xanthus has a nutrient-regulated biphasic life cycle forming predatory swarms in the presence of nutrients and spore-filled fruiting bodies in the absence of nutrients.
Sofya Kuzmich, Patrick Blumenkamp, Doreen Meier, Dobromir Szadkowski, Alexander Goesmann, Anke Becker, Lotte Søgaard-Andersen   +6 more
doaj   +2 more sources

Multiple Roles of c-di-GMP Signaling in Bacterial Pathogenesis.

Annual Review of Microbiology, 2019
The intracellular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of bacteria and controls many key functions and mechanisms. In the case of bacterial pathogens, a wide variety of virulence lifestyle factors have been shown to be ...
Martina Valentini, A. Filloux
semanticscholar   +3 more sources

A WYL domain transcription factor regulates Lactiplantibacillus plantarum intestinal colonization via perceiving c-di-GMP [PDF]

Nature Communications
Cyclic diguanosine monophosphate (c-di-GMP) functions as a crucial bacterial second messenger to control diverse biological functions. Although numerous studies have reported the health effects of Lactiplantibacillus plantarum, the regulatory role of c ...
Quan Guo, Guangqiang Wang, Leijie Zheng, Hui Xue, Ruimin Wang, Yajing Fang, Jiachao Zhang   +6 more
doaj   +2 more sources

Intact and mutated Shigella diguanylate cyclases increase c-di-GMP. [PDF]

J Biol Chem
The intracellular human pathogen Shigella invades the colonic epithelium to cause disease. Prior to invasion, this bacterium navigates through different environments within the human body, including the stomach and the small intestine. To adapt to changing environments, Shigella uses the bacterial second messenger cyclic di-GMP (c di-GMP) signaling ...
Ojha R, Krug S, Jones P, Koestler BJ.
europepmc   +3 more sources

Bacterial c-di-GMP triggers metamorphosis of mussel larvae through a STING receptor [PDF]

npj Biofilms and Microbiomes
Bacteria induced metamorphosis observed in nearly all marine invertebrates. However, the mechanism of bacteria regulating the larvae-juvenile metamorphosis remains unknown.
Xiao-Meng Hu, Lihua Peng, Yuyi Wang, Fan Ma, Yu Tao, Xiao Liang, Jin-Long Yang   +6 more
doaj   +2 more sources