c-di-GMP Inhibits Early Sporulation in Clostridioides difficile [PDF]
mSphere, 2021 The formation of dormant spores is essential for the anaerobic pathogen Clostridioides difficile to survive outside the host gastrointestinal tract. The regulatory pathways and environmental signals that initiate C.
Adrianne N. Edwards +4 more
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Journal of Biological Chemistry, 2016 The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers.
Martina Valentini, Alain Filloux
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A WYL domain transcription factor regulates Lactiplantibacillus plantarum intestinal colonization via perceiving c-di-GMP [PDF]
Nature CommunicationsCyclic diguanosine monophosphate (c-di-GMP) functions as a crucial bacterial second messenger to control diverse biological functions. Although numerous studies have reported the health effects of Lactiplantibacillus plantarum, the regulatory role of c ...
Quan Guo +6 more
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Identification and Characterization of c-di-GMP Metabolic Enzymes of Leptospira interrogans and c-di-GMP Fluctuations After Thermal Shift and Infection [PDF]
Frontiers in Microbiology, 2018 Leptospirosis is a widespread zoonotic disease caused by pathogenic Leptospira species. The most common species, Leptospira interrogans, can transfer from contaminated soil or water to the human body.
Guohui Xiao +9 more
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One‐Flask Synthesis of Cyclic Diguanosine Monophosphate (c‐di‐GMP) [PDF]
Current Protocols in Nucleic Acid Chemistry, 2023 AbstractThe bacterial signaling molecule, cyclic diguanosine monophosphate (c‐di‐GMP), plays a key role in controlling biofilm formation and pathogenic virulence, among many other functions. It has widespread consequences for human health, and current research is actively exploring its molecular mechanisms.
Barbara L. Gaffney, Roger A. Jones
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Local c-di-GMP signaling, triggered by cross-regulation of cAMP-CRP and c-di-GMP, controls biofilm formation under nutrient limitation. [PDF]
Proc Natl Acad Sci U S ASun D +11 more
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Bacterial c-di-GMP triggers metamorphosis of mussel larvae through a STING receptor [PDF]
npj Biofilms and MicrobiomesBacteria induced metamorphosis observed in nearly all marine invertebrates. However, the mechanism of bacteria regulating the larvae-juvenile metamorphosis remains unknown.
Xiao-Meng Hu +6 more
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Architecture and regulatory functions of c-di-GMP signaling in classical Bordetella species. [PDF]
FEMS Microbiol RevVondrova D +6 more
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Detection of c-di-GMP-Responsive DNA Binding [PDF]
, 2017 Modulation of signal transduction via binding of the secondary messenger molecule cyclic di-GMP to effector proteins is a near universal regulatory schema in bacteria. In particular, direct binding of c-di-GMP to transcriptional regulators has been shown to alter gene expression of a variety of processes.
Jacob R. Chambers, Karin Sauer
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Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle. [PDF]
PLoS Genetics, 2013 Many bacteria mediate important life-style decisions by varying levels of the second messenger c-di-GMP. Behavioral transitions result from the coordination of complex cellular processes such as motility, surface adherence or the production of virulence ...
Sören Abel +6 more
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