Results 11 to 20 of about 459,122 (273)

Visualization of c-di-GMP in multicellular Dictyostelium stages. [PDF]

Front Cell Dev Biol, 2023
The bacterial signaling molecule cyclic diguanosine monophosphate (c-di-GMP) is only synthesized and utilized by the cellular slime mold Dictyostelium discoideum among eukaryotes. Dictyostelium cells undergo a transition from a unicellular to a multicellular state, ultimately forming a stalk and spores.
Ide H, Hayashida Y, Morimoto YV.
europepmc   +4 more sources

A genetically encoded biosensor to monitor dynamic changes of c-di-GMP with high temporal resolution. [PDF]

Nat Commun
Monitoring changes of signaling molecules and metabolites with high temporal resolution is key to understanding dynamic biological systems. Here, we use directed evolution to develop a genetically encoded ratiometric biosensor for c-di-GMP, a ubiquitous ...
Kaczmarczyk A, van Vliet S, Jakob RP, Teixeira RD, Scheidat I, Reinders A, Klotz A, Maier T, Jenal U.   +8 more
europepmc   +2 more sources

A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa. [PDF]

Nat Commun
Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a bacterial second messenger that modulates various processes including biofilm formation, motility, and host-microbe symbiosis.
Zhan X, Zhang K, Wang C, Fan Q, Tang X, Zhang X, Wang K, Fu Y, Liang H.   +8 more
europepmc   +2 more sources

Reciprocal c-di-GMP signaling: Incomplete flagellum biogenesis triggers c-di-GMP signaling pathways that promote biofilm formation [PDF]

PLOS Genetics, 2020
The assembly status of the V. cholerae flagellum regulates biofilm formation, suggesting that the bacterium senses a lack of movement to commit to a sessile lifestyle. Motility and biofilm formation are inversely regulated by the second messenger molecule cyclic dimeric guanosine monophosphate (c-di-GMP).
Daniel C. Wu, David Zamorano-Sánchez, Fernando A. Pagliai, Jin Hwan Park, Kyle A. Floyd, Calvin K. Lee, Giordan Kitts, Christopher B. Rose, Eric M. Bilotta, Gerard C. L. Wong, Fitnat H. Yildiz   +10 more
openaire   +7 more sources

From Input to Output: The Lap/c-di-GMP Biofilm Regulatory Circuit [PDF]

Annual Review of Microbiology, 2020
Biofilms are the dominant bacterial lifestyle. The regulation of the formation and dispersal of bacterial biofilms has been the subject of study in many organisms. Over the last two decades, the mechanisms of Pseudomonas fluorescens biofilm formation and
Alan J. Collins, T. Jarrod Smith, Holger Sondermann, George A. O’Toole   +3 more
openalex   +2 more sources

c-di-GMP inhibits early sporulation in Clostridioides difficile [PDF]

mSphere, 2021
Many bacterial organisms utilize the small signaling molecule cyclic diguanylate (c-di-GMP) to regulate important physiological processes, including motility, toxin production, biofilm formation, and colonization. c-di-GMP inhibits motility and toxin production and promotes biofilm formation and colonization in the anaerobic ...
Adrianne N. Edwards, Caitlin L. Willams, Nivedita Pareek, Shonna M. McBride, Rita Tamayo   +4 more
openalex   +5 more sources

Precise timing of transcription by c-di-GMP coordinates cell cycle and morphogenesis in Caulobacter [PDF]

Nature Communications, 2020
Bacteria adapt their growth rate to their metabolic status and environmental conditions by modulating the length of their G1 period. Here we demonstrate that a gradual increase in the concentration of the second messenger c-di-GMP determines precise gene
Andreas Kaczmarczyk, Antje M. Hempel, Christoph von Arx, Raphael Böhm, Badri N. Dubey, Jutta Nesper, Tilman Schirmer, Sebastian Hiller, Urs Jenal   +8 more
openalex   +2 more sources

A Trigger Phosphodiesterase Modulates the Global c-di-GMP Pool, Motility, and Biofilm Formation in Vibrio parahaemolyticus

bioRxiv, 2021
c-di-GMP trigger phosphodiesterases (PDEs) could play a key role in controlling the heterogeneity of biofilm matrix composition, a property that endows characteristics that are potentially relevant for sustaining integrity and functionality of biofilms ...
Raquel Martínez-Méndez, Diego A. Camacho-Hernández, Elizabeth Sulvarán-Guel, David Zamorano‐Sánchez   +3 more
openalex   +3 more sources

Multiple Roles of c-di-GMP Signaling in Bacterial Pathogenesis

Annual Review of Microbiology, 2019
The intracellular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of bacteria and controls many key functions and mechanisms. In the case of bacterial pathogens, a wide variety of virulence lifestyle factors have been shown to be regulated by c-di-GMP.
Valentini, Martina, Filloux, Alain
openaire   +5 more sources

cAMP and c-di-GMP synergistically support biofilm maintenance through the direct interaction of their effectors

Nature Communications, 2022
Nucleotide second messengers, such as cAMP and c-di-GMP, regulate many physiological processes in bacteria, including biofilm formation. There is evidence of cross-talk between pathways mediated by c-di-GMP and those mediated by the cAMP receptor protein
Cong Liu, Di Sun, Jiawen Liu, Ying Chen, Xuge Zhou, Yunrui Ru, Jingrong Zhu, Weijie Liu   +7 more
semanticscholar   +1 more source