Results 71 to 80 of about 29,655,632 (304)
Computational Study of Tandem C-C Coupling and C-H Activation Reaction of a Flexible Substrate [PDF]
, 2019 We carried out an extensive density functional theory calculations on the Pd catalyzed intramolecular Heck reaction followed by C-H activation of a flexible substrate like Stilbene ...
Anakuthil, Anoop +3 more
core +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Mechanism of the Arene-Limited Nondirected C–H Activation of Arenes with Palladium [PDF]
, 2021 Recently palladium catalysts have been discovered that enable the directing group-free C–H activation of arenes without requiring an excess of the arene substrate, thereby enabling methods for the late-stage modification of complex organic molecules. The
Philipp, Wedi +4 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Visible light-driven C−H activation and C–C coupling of methanol into ethylene glycol
Nature Communications, 2018 Direct transformation of methanol into two- or multi-carbon compounds is extremely attractive but remains a challenge. Here, the authors report an efficient photocatalytic route to the transformation of methanol into ethylene glycol and hydrogen over a ...
Shunji Xie +10 more
doaj +1 more source
The ortho effect in directed C–H activation
Chemical Science, 2021 The term and concept of Ortho Effect (OE) is introduced for the description of steric effects in transition metal catalyzed directed ortho C–H activation reactions to explain and predict reactivities of substrates.
Tóth, Balázs L +7 more
openaire +5 more sources
Chiral Arene Ligand as Stereocontroller for Asymmetric C-H Activation [PDF]
, 2022 Development of chiral ligands is the most fundamental task in metal-catalyzed asymmetric synthesis. In the last 60 years, various kinds of ligands have been sophisticatedly developed.
Weicong, Guo +4 more
core +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Molecules, 2020 The transition metal-catalyzed C–H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C–H functionalization of various heteroarenes,
Su Chen +4 more
doaj +1 more source
, 2019 Reported is a tandem palladium-catalyzed Heck/regioselective C(sp(3))-H activation reaction for the divergent synthesis of spiro- and fused-cyclopropanated indolines from N-methallylated 2-bromoarylamides.
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