Results 81 to 90 of about 31,423,583 (299)

Enantioselective Cobaltaphotoredox-Catalyzed C-H Activation. [PDF]

J Am Chem Soc
The quest for sustainable strategies in molecular synthesis has spurred the emergence of photocatalysis as a particularly powerful technique. In recent years, the application of photocatalysis in this context has greatly promoted the development of asymmetric catalysis.
Xu Y, Lin Y, Homölle SL, Oliveira JCA, Ackermann L.   +4 more
europepmc   +4 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Stereoselective Radical Translocations

CHIMIA, 2008
The stereochemical outcome of intramolecular radical mediated hydrogen transfer (= radical translocation) is discussed. Low to excellent levels of stereocontrol are observed making such processes attractive for applications in target-oriented ...
Philippe Renaud, Florent Beaufils, Fabrice Dénès, Laurence Feray, Christoph Imboden, Nikolai Kuznetsov   +5 more
doaj   +1 more source

Synergistic Activation of Amides and Hydrocarbons for Direct C(sp3)–H Acylation Enabled by Metallaphotoredox Catalysis

, 2020
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimThe utilizations of omnipresent, thermodynamically stable amides and aliphatic C(sp3)−H bonds for various functionalizations are ongoing challenges in catalysis.
Geun Seok Lee, Mu‐Hyun Baik, Joonghee Won, Seulhui Choi, Mu-Hyun Baik, Soon Hyeok Hong   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Activation of H-H, C-H, C-C and C-Cl bonds by Pd and PdCl-. Understanding anion assistance in C-X bond activation

, 2005
To understand the mechanism of anion assistance in palladium-catalyzed H-H, C-H, C-C and C-Cl bond activation, several mechanistic pathways for oxidative addition of Pd and ...
Bickelhaupt, F.M., de Jong, G.T., Diefenbach, A.   +2 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Palladium-Catalyzed Divergent Cyclopropanation by Regioselective Solvent-Driven C(sp3)?H Bond Activation

, 2018
Reported is a tandem palladium-catalyzed Heck/regioselective C(sp3)?H activation reaction for the divergent synthesis of spiro- and fused-cyclopropanated indolines from N-methallylated 2-bromoarylamides. The regioselectivity of the C?H bond activation in
Da Sol Chung, Jiyong Park, Joo Hyun Lee, UBin Kim, Hyunjoong Kim, Mu-Hyun Baik, Sang-gi Lee, Jae Sung Lee, Won Koo Lee, Ho Ryu   +9 more
core   +1 more source