Results 1 to 10 of about 195,376 (282)
c-Jun N-terminal kinase signaling in aging [PDF]
Frontiers in Aging NeuroscienceAging encompasses a wide array of detrimental effects that compromise physiological functions, elevate the risk of chronic diseases, and impair cognitive abilities.
Yihao Li +10 more
doaj +4 more sources
Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase [PDF]
Neural Plasticity, 2017 The c-Jun N-terminal kinase (JNK) is part of a stress signalling pathway strongly activated by NMDA-stimulation and involved in synaptic plasticity. Many studies have been focused on the post-synaptic mechanism of JNK action, and less is known about JNK ...
Silvia Biggi +8 more
doaj +8 more sources
c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity [PDF]
Marine Drugs, 2013 Plitidepsin is an antitumor drug of marine origin currently in Phase III clinical trials in multiple myeloma. In cultured cells, plitidepsin induces cell cycle arrest or an acute apoptotic process in which sustained activation of c-Jun N-terminal kinase (
Alberto Muñoz +6 more
doaj +2 more sources
Relationship Between c-Jun N-terminal Kinase and Depression [PDF]
E3S Web of Conferences, 2020 Depression is one of the most common emotional disorders. The cause of depression is still not clear. C-Jun N-terminal kinase (JNK) is one number of mitogen activated protein kinase (MAPK) family, which is closely related to the occurrence of many ...
Ma Hongpeng
doaj +2 more sources
MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus [PDF]
Biology Open, 2016 Ocular morphogenesis requires several signalling pathways controlling the expression of transcription factors and cell-cycle regulators. However, despite a well-known mechanism, the dialogue between those signals and factors remains to be unveiled. Here,
Barbara Vacca +7 more
doaj +6 more sources
C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes
Computational and Structural Biotechnology Journal, 2020 The activation of c-Jun N-terminal kinases (JNKs) plays an important role in physiological processes including neuronal function, immune activity, and development, and thus, JNKs have been a therapeutic target for various diseases such as ...
Men Thi Hoai Duong +2 more
doaj +3 more sources
On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory [PDF]
Frontiers in Behavioral Neuroscience, 2022 c-Jun N-terminal kinase (JNK) phosphorylates the transcription factor c-Jun in response to stress stimuli and contributes to both hippocampal synaptic plasticity and memory processing in mammals.
Janine I. Rossato +7 more
doaj +2 more sources
c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease. [PDF]
PLoS Genetics, 2021 Polycystic kidney disease is an inherited degenerative disease in which the uriniferous tubules are replaced by expanding fluid-filled cysts that ultimately destroy organ function.
Abigail O Smith +4 more
doaj +2 more sources
Stressor-like effects of c-Jun N-terminal kinase (JNK) inhibition. [PDF]
PLoS ONE, 2012 There is an urgent need for novel treatment strategies for stressor related disorders, particularly depression and anxiety disorders. Indeed, existing drug treatments are only clinically successful in a subset of patients and relapse is common.
Melanie Clarke +3 more
doaj +1 more source
Pharmaceutical Sciences and Research, 2021 The role of in silico studies in the discovery of new drugs is very important and interesting in the recent years, where the results can be used as confirmation of the results of in vitro tests carried out experimentally in the laboratory.
Fitrianti Darusman +1 more
doaj +1 more source