Results 221 to 230 of about 195,376 (282)

A Case of Cytokine Release Syndrome Induced by Avelumab and Axitinib Combination Therapy for Metastatic Renal Cell Carcinoma

IJU Case Reports, Volume 9, Issue 2, March 2026.
ABSTRACT Introduction Cytokine release syndrome (CRS) is a rare immune‐related adverse event of immune checkpoint inhibitors (ICIs). At present, its association with avelumab–axitinib therapy for renal cell carcinoma (RCC) has yet to be reported. Differentiating early CRS from an infusion‐related reaction (IRR) is clinically challenging, particularly ...
Rio Shibata, Taku Mochizuki, Takashi Kawahara, Tomoharu Morikawa, Hirokazu Kiuchi, Takahiro Hanai, Jun‐ichi Teranishi, Kimio Chiba   +7 more
wiley   +1 more source

Differential Regulation of Wingless-Wnt/c-Jun N-Terminal Kinase Crosstalk via Oxidative Eustress in Primary and Metastatic Colorectal Cancer Cells. [PDF]

Biomedicines
Aceto GM, Pagotto S, Del Pizzo FD, Saoca C, Selvaggi F, Visone R, Cotellese R, Aguennouz M, Lattanzio R, Catalano T.   +9 more
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

α-Bisabolol alleviates diesel exhaust particle-induced lung injury and mitochondrial dysfunction by regulating inflammatory, oxidative stress, and apoptotic biomarkers through the c-Jun N-terminal kinase signaling pathway. [PDF]

Front Pharmacol
Beegam S, Zaaba NE, Elzaki O, Nemmar A.
europepmc   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Identification of potent schistosomicidal compounds predicted as type II-kinase inhibitors against Schistosoma mansoni c-Jun N-terminal kinase SMJNK. [PDF]

Front Parasitol
Moreira BP, Gava SG, Haeberlein S, Gueye S, Santos ESS, Weber MHW, Abramyan TM, Grevelding CG, Mourão MM, Falcone FH.   +9 more
europepmc   +1 more source

Cytokine Dynamics in Bortezomib‐Induced Peripheral Neuropathy: Challenges in Translating Preclinical Findings to Humans

Journal of the Peripheral Nervous System, Volume 31, Issue 1, March 2026.
ABSTRACT Background and Aims Bortezomib‐induced peripheral neuropathy (BIPN) remains a common treatment side effect in patients with multiple myeloma (MM). Data from rodent models indicate a role of proinflammatory cytokines in BIPN pathophysiology, making them potential therapeutic targets.
Nadine Cebulla, Daniel Schirmer, Eva Runau, Leon Flamm, Calvin Terhorst, Laura Jähnel, Johanna Güse, Nicola Giordani, Annett Wieser, Felicitas Schoch, Marie‐Luise Reinle, Sonja Gommersbach, Aikaterini Papagianni, Xiang Zhou, Hermann Einsele, Ann‐Kristin Reinhold, Heike Rittner, K. Martin Kortüm, Claudia Sommer   +18 more
wiley   +1 more source

Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c‑Jun N‑Terminal Kinase 3

ACS Omega, 2018
Francesco Ansideri, Joana T. Macedo, Michael Eitel, Ahmed El-Gokha, Dhafer S. Zinad, Camilla Scarpellini, Mark Kudolo, Dieter Schollmeyer, Frank M. Boeckler, Bärbel S. Blaum, Stefan A. Laufer, Pierre Koch   +11 more
doaj   +1 more source

Interleukin-1β induces and accelerates human endometrial stromal cell senescence and impairs decidualization via the c-Jun N-terminal kinase pathway. [PDF]

Cell Death Discov
Taylor RN, Berga SL, Zou E, Washington J, Song S, Marzullo BJ, Bagchi IC, Bagchi MK, Yu J.   +8 more
europepmc   +1 more source

A novel single‐cell NAD‐ME C4 subtype integrated with CAM and bicarbonate use in an aquatic plant

New Phytologist, Volume 249, Issue 5, Page 2386-2401, March 2026.
Summary Many plants maximize photosynthesis by using a CO2‐concentrating mechanism (CCM). Based on physiology, the freshwater plant Ottelia alismoides has three CCMs: C4 metabolism (NAD‐malic enzyme (NAD‐ME) subtype) and bicarbonate‐use during the day plus crassulacean acid metabolism (CAM) at night and lacks Kranz anatomy. Here, we combined a range of
Hong Sheng Jiang, Wenmin Huang, Shijuan Han, Pengpeng Li, Zuying Liao, Liyuan Wei, Lei Zhao, Shuping Gu, Jun Ding, Brigitte Gontero, Stephen C. Maberly, Wei Li   +11 more
wiley   +1 more source