Results 81 to 90 of about 467,569 (310)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Periplasmic Protein Mobility for Extracellular Electron Transport in Shewanella oneidensis

Microorganisms
Extracellular electron transport (EET) supports the survival of specific microorganisms on the Earth’s surface by facilitating microbial respiration with diverse electron acceptors.
Daobo Li, Xiaodan Zheng, Yonggang Yang, Meiying Xu   +3 more
doaj   +1 more source

Characterization of a novel PQQ-dependent quinohemoprotein pyranose dehydrogenase from Coprinopsis cinerea classified into auxiliary activities family 12 in carbohydrate-active enzymes. [PDF]

PLoS ONE, 2015
The basidiomycete Coprinopsis cinerea contains a quinohemoprotein (CcPDH named as CcSDH in our previous paper), which is a new type of pyrroloquinoline-quinone (PQQ)-dependent pyranose dehydrogenase and is the first found among all eukaryotes.
Kouta Takeda, Hirotoshi Matsumura, Takuya Ishida, Masahiro Samejima, Hiroyuki Ohno, Makoto Yoshida, Kiyohiko Igarashi, Nobuhumi Nakamura   +7 more
doaj   +1 more source

Copper acquisition by the SenC protein regulates aerobic respiration in Pseudomonas aeruginosa PAO1 [PDF]

, 2017
Aerobic respiration of Pseudomonas aeruginosa involves four terminal oxidases belonging to the heme-copper family (that is, three cytochrome c oxidases and one quinol oxidase) plus one copper-independent, cyanide-insensitive quinol oxidase (CIO).
Frangipani, Emanuela, Haas, Dieter
core  

Electrochemical titrations and reaction time courses monitored in situ by magnetic circular dichroism spectroscopy [PDF]

, 2011
Magnetic circular dichroism (MCD) spectra, at ultraviolet–visible or near-infrared wavelengths (185–2000 nm), contain the same transitions observed in conventional absorbance spectroscopy, but their bisignate nature and more stringent selection rules ...
Abramson, Allen, Armstrong, Cheesman, Cheesman, Cheesman, Cheesman, Craft, Dooley, Duin, Farrar, Field, Fulop, Gadsby, Gamelin, Gates, George, Hadler, Horio, Hänzelmann, Johnson, Johnson, Johnson, Jones, Julea N. Butt, Justin M. Bradley, Kemp, Kobayashi, Koppenhofer, Larrabee, Male, Marritt, Marritt, Mitić, Mitou, Moir, Myles R. Cheesman, Paes de Sousa, Pauleta, Quintanar, Rasmussen, Richter, Rupnik, Simon, Solomon, Solomon, Solomon, Suharti, Thomson, Thomson, van Gelder, Vickery, Walters   +52 more
core   +1 more source

Biochemical requirements for the maturation of mitochondrial c-type cytochromes

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Cytochromes c are metalloproteins that function in electron transfer reactions and contain a heme moiety covalently attached via thioether linkages between the co-factor and a CXXCH motif in the protein. Covalent attachment of the heme group occurs on the positive side of all energy-transducing membranes (bacterial periplasm, mitochondrial ...
Hamel, Patrice, Corvest, Vincent, Giegé, Philippe, Bonnard, Géraldine   +3 more
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

The ‘porin-cytochrome’ model for microbe-to-mineral electron transfer [PDF]

, 2012
Many species of bacteria can couple anaerobic growth to the respiratory reduction of insoluble minerals containing Fe(III) or Mn(III/IV). It has been suggested that in Shewanella species electrons cross the outer membrane to extracellular substrates via ‘
Afkar, Baron, Bouhenni, Burns, Cao, Clarke, Clarke, Clarke, Coursolle, DiChristina, Dohnalkova, Donald, Eggleston, El-Naggar, Firer-Sherwood, Firer-Sherwood, Gorby, Gralnick, Hartshorne, Hartshorne, Heidelberg, Jensen, Jiang, Jiao, Johs, Kerisit, Leang, Lies, Liu, Lower, Lower, Lower, Malvankar, Malvankar, Marsili, McLean, Meitl, Myers, Peretyazhko, Pessanha, Qian, Reardon, Reguera, Reguera, Roessler, Ross, Schuetz, Shi, Shi, Smith, Strycharz-Glaven, Strycharz-Glaven, Taylor, von Canstein, Xiong, Zargar, Zhang, Zhang   +57 more
core   +2 more sources

Stark effect experiments in cytochrome c-type proteins: structural hierarchies

Biophysical Journal, 1996
We performed hole-burning Stark effect experiments on cytochrome c in which the iron of the herne was either removed or replaced by Zn. According to the experiments, the free-base compound has an effective inversion center, even in the protein. The Zn compound, on the other hand, shows quite peculiar features: in the low-frequency range of the ...
Köhler, M., Gafert, J., Friedrich, J., Vanderkooi, J.M., Laberge, M.   +4 more
openaire   +2 more sources

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source