Results 21 to 30 of about 161,532 (260)

Computational and experimental prediction of human C-type lectin receptor druggability

Frontiers in Immunology, 2014
Mammalian C-type lectin receptors are involved in many aspects of immune cell regulation such as pathogen recognition, clearance of apoptotic bodies and lymphocyte homing.
Jonas eAretz, Jonas eAretz, Eike-Christian eWamhoff, Eike-Christian eWamhoff, Jonas eHanske, Jonas eHanske, Dario eHeymann, Christoph eRademacher, Christoph eRademacher   +8 more
doaj   +1 more source

Structurally Robust and Functionally Highly Versatile—C-Type Lectin (-Related) Proteins in Snake Venoms

Toxins, 2019
Snake venoms contain an astounding variety of different proteins. Among them are numerous C-type lectin family members, which are grouped into classical Ca2+- and sugar-binding lectins and the non-sugar-binding snake venom C-type lectin-related proteins (
Johannes A. Eble
doaj   +1 more source

Characterization of the receptors for mycobacterial cord factor in Guinea pig. [PDF]

PLoS ONE, 2014
Guinea pig is a widely used animal for research and development of tuberculosis vaccines, since its pathological disease process is similar to that present in humans.
Kenji Toyonaga, Yasunobu Miyake, Sho Yamasaki   +2 more
doaj   +1 more source

Lectins with Anti-HIV Activity: A Review

Molecules, 2015
Lectins including flowering plant lectins, algal lectins, cyanobacterial lectins, actinomycete lectin, worm lectins, and the nonpeptidic lectin mimics pradimicins and benanomicins, exhibit anti-HIV activity.
Ouafae Akkouh, Tzi Bun Ng, Senjam Sunil Singh, Cuiming Yin, Xiuli Dan, Yau Sang Chan, Wenliang Pan, Randy Chi Fai Cheung   +7 more
doaj   +1 more source

Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity

Frontiers in Immunology, 2018
Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity.
Juan Tang, Guoxin Lin, Guoxin Lin, Wallace Y. Langdon, Lijian Tao, Jian Zhang   +5 more
doaj   +1 more source

C-type lectins facilitate tumor metastasis

Oncology Letters, 2016
Metastasis, a life-threatening complication of cancer, leads to the majority of cases of cancer-associated mortality. Unfortunately, the underlying molecular and cellular mechanisms of cancer metastasis remain to be fully elucidated. C-type lectins are a large group of proteins, which share structurally homologous carbohydrate-recognition domains (CRDs)
Ding, Dongbing, Yao, Yao, Zhang, Songbai, Su, Chunjie, Zhang, Yonglian   +4 more
openaire   +3 more sources

C-Type Lectin Receptors in Host Defense Against Bacterial Pathogens

Frontiers in Cellular and Infection Microbiology, 2020
Antigen-presenting cells (APCs) are present throughout the human body—in tissues, at barrier sites and in the circulation. They are critical for processing external signals to instruct both local and systemic responses toward immune tolerance or immune ...
Malgorzata E. Mnich, Malgorzata E. Mnich, Rob van Dalen, Nina M. van Sorge, Nina M. van Sorge   +4 more
doaj   +1 more source

Drosophila C-type lectins enhance cellular encapsulation [PDF]

Molecular Immunology, 2007
C-type lectins are calcium-dependent carbohydrate binding proteins, and animal C-type lectins participate in innate immunity and cell-cell interactions. In the fruit fly Drosophila melanogaster, more than 30 genes encode C-type lectin domains. However, functions of Drosophila C-type lectins in innate immunity are not well understood.
Jingqun, Ao, Erjun, Ling, Xiao-Qiang, Yu
openaire   +2 more sources

Differing Expression and Potential Immunological Role of C-Type Lectin Receptors of Two Different Chicken Breeds against Low Pathogenic H9N2 Avian Influenza Virus

Pathogens
Diverse immune responses in different chicken lines can result in varying clinical consequences following avian influenza virus (AIV) infection. We compared two widely used layer breeds, Lohmann Brown (LB) and Lohmann White (LW), to examine virus ...
Sungsu Youk, Dong-Hun Lee, Chang-Seon Song   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source