Results 31 to 40 of about 161,532 (260)

Cytotoxicity and Glycan-Binding Properties of an 18 kDa Lectin Isolated from the Marine Sponge <em>Halichondria </em><em>o</em><em>kadai</em>

Toxins, 2012
A divalent cation-independent lectin—HOL-18, with cytotoxic activity against leukemia cells, was purified from a demosponge, <em>Halichondria okadai</em>. HOL-18 is a 72 kDa tetrameric lectin that consists of four non-covalently bonded 18 kDa
Yasuhiro Ozeki, Jiharu Hamako, Taei Matsui, Kazuo Nitta, Masahiro Hosono, Shigeki Sugawara, Chang Hun Im, Yukiko Ogawa, Hidetaro Yasumitsu, Robert A. Kanaly, Sarkar M. A. Kawsar, Yuki Fujii, Ryo Matsumoto, Chihiro Iwahara, Imtiaj Hasan, Yasuhiro Koide   +15 more
doaj   +1 more source

Comparative transcriptomics reveals the immune dynamics during the molting cycle of swimming crab Portunus trituberculatus

Frontiers in Immunology, 2022
Molting is one of the most important biological processes of crustacean species, and a number of molecular mechanisms facilitate this complex procedure. However, the understanding of the immune mechanisms underlying crustacean molting cycle remains very ...
Meimei Liu, Meimei Liu, Hongwei Ni, Xiaokang Zhang, Qiufeng Sun, Xugan Wu, Jie He   +6 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Purification and biological effects of a C-type lectin isolated from Bothrops moojeni

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
Snake venom proteins from the C-type lectin family have very distinct biological activities despite their highly conserved primary structure, which is homologous to the carbohydrate recognition region of true C-type lectins.
PSF Barbosa, AMC Martins, MH Toyama, PP Joazeiro, LOS Beriam, MC Fonteles, HSA Monteiro   +6 more
doaj   +1 more source

Necrosis: C-Type Lectins Sense Cell Death [PDF]

Current Biology, 2009
Recent studies have shown that C-type lectins, a family of surface receptors known to recognize microbial carbohydrate moieties, also sense products from dying cells and transduce inflammatory signals that modulate the immune system.
Cambi, A., Figdor, C.G.
openaire   +4 more sources

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions. [PDF]

PLoS ONE, 2015
Regulatory T cells (Tregs) are physiologically designed to prevent autoimmune disease and maintain self-tolerance. In tumour microenvironments, their presence is related to a poor prognosis, and they influence the therapeutic outcome due to their ...
Ilaria Grazia Zizzari, Paola Martufi, Federico Battisti, Hassan Rahimi, Salvatore Caponnetto, Filippo Bellati, Marianna Nuti, Aurelia Rughetti, Chiara Napoletano   +8 more
doaj   +1 more source

Multifunctional Snake C-Type Lectins Affecting Platelets [PDF]

Pathophysiology of Haemostasis and Thrombosis, 2001
Snake venoms contain a wide range of components, many of which affect haemostasis by activation or inhibition of platelets or coagulation factors. They can be classified into groups based on structure and mode of action. One group is the snake C-type lectins, so called because of the typical folding which closely resembles that found in classical C ...
K J, Clemetson, A, Navdaev, D, Dörmann, X Y, Du, J M, Clemetson   +4 more
openaire   +2 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Sex differences in carbohydrate metabolism are linked to gene expression in Caenorhabditis elegans. [PDF]

PLoS ONE, 2012
The male and the hermaphrodite forms of the nematode Caenorhabditis elegans (C. elegans) differ markedly in anatomy, nervous system and behavior at adulthood.
Claudia Miersch, Frank Döring
doaj   +1 more source