Results 231 to 240 of about 84,931 (265)

C-Type Lectin Receptors in Phagocytosis

2020
C-type lectin receptors (CLRs) are a family of transmembrane proteins having at least one C-type lectin-like domain (CTLD) on the cell surface and either a short intracellular signaling tail or a transmembrane domain that facilitates interaction with a second protein, often the Fc receptor common gamma chain (FcRγ), that mediates signaling.
Kai, Li, David M, Underhill
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C-type lectin receptors in antifungal immunity

Trends in Microbiology, 2008
Fungal infections represent a significant health burden, especially in immunocompromised individuals, yet many of the underlying immunological mechanisms involved in the recognition and control of these pathogens are unclear. The identification of the Toll-like receptors (TLRs) has shed new insights on innate microbial recognition and the initiation of
Janet A, Willment, Gordon D, Brown
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C-Type Lectin Receptors in Antifungal Immunity

2020
Most fungal species are harmless to humans and some exist as commensals on mucocutaneous surfaces. Yet many fungi are opportunistic pathogens, causing life-threatening invasive infections when the immune system becomes compromised. The fungal cell wall contains conserved pathogen-associated molecular patterns (PAMPs), which allow the immune system to ...
Christina, Nikolakopoulou, Janet A, Willment, Gordon D, Brown   +2 more
openaire   +2 more sources

C-type lectin receptors on dendritic cells and langerhans cells

Nature Reviews Immunology, 2002
Dendritic cells and Langerhans cells are specialized for the recognition of pathogens and have a pivotal role in the control of immunity. As guardians of the immune system, they are present in essentially every organ and tissue, where they operate at the interface of innate and acquired immunity.
Carl G Figdor, Yvette Van Kooyk, Gosse J Adema   +2 more
exaly   +5 more sources

Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors

International Journal for Parasitology, 2012
During infection with the blood fluke Schistosoma mansoni, glycan motifs present on glycoproteins of the parasite's eggs mediate immunomodulatory effects on the host. The recognition of these glycan motifs is primarily mediated by C-type lectin receptors
HERMELIJN H Smits, Sandra J Van Vliet, Gabriele Schramm   +2 more
exaly   +2 more sources

C-type lectin receptors in anti-fungal immunity

Current Opinion in Microbiology, 2017
Host immune systems are constantly engaged with fungal pathogens which are common in environments as well as in healthy human skin and mucosa. C-type lectin receptors (CLRs) are expressed in myeloid cells and play central roles in host defenses against fungal infections by coordinating innate and adaptive immune systems.
Moe, Shiokawa, Sho, Yamasaki, Shinobu, Saijo   +2 more
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C-type lectin receptors in the control of T helper cell differentiation

Nature Reviews Immunology, 2016
Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is important not only for antigen presentation, but also for the induction of appropriate adaptive immune responses via T helper (TH) cell differentiation.
Teunis B H Geijtenbeek, Geijtenbeek Teunis B H   +1 more
exaly   +2 more sources

Targeting C-type lectin receptors with multivalent carbohydrate ligands

Advanced Drug Delivery Reviews, 2013
C-type lectin receptors (CLRs) represent a large receptor family including collectins, selectins, lymphocyte lectins, and proteoglycans. CLRs share a structurally homologous carbohydrate-recognition domain (CRD) and often bind carbohydrates in a Ca²⁺-dependent manner.
Bernd Lepenies, Junghoon Lee, Sanjiv Sonkaria   +2 more
exaly   +4 more sources

C-type lectin receptors and cytokines in fungal immunity

Cytokine, 2012
Fungi are the cause of opportunistic infections, predominantly in immunocompromised individuals although, primary fungal infections can occur in apparently healthy individuals. Successful host defence requires an effective innate and adaptive immune response.
Simon, Vautier, Donna M, MacCallum, Gordon D, Brown   +2 more
openaire   +2 more sources

The C-Type Lectin Receptors

C-type lectins (CTLs) form a broad and diverse protein superfamily with the ability to identify a wide array of ligands with their characteristic C-type lectin-like domains (CTLDs), thus governing a broad spectrum of physiological functions. CTLD-containing proteins (CTLDcps) are now classified into 17 groups based on their phylogeny and overall domain
Kasturi, Ganguly, Taruna, Madan
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