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Signaling C-Type Lectin Receptors in Antifungal Immunity
2020We are all exposed to fungal organisms daily, and although many of these organisms are not harmful, billions of people a year contract a fungal infection. Most of these infections are not fatal and can be cleared by the host immune response. However, due to an increase in high-risk populations, the global fungal burden has increased, with more than 1.5
Maxine A, Höft +2 more
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The role of C-type lectin receptors in immune homeostasis
International Immunopharmacology, 2013C-type lectin receptors (CLRs) are important pathogen pattern recognition molecules that recognize carbohydrate structures. Upon ligand binding, CLRs induce a variety of cellular responses, such as respiratory burst, production of cytokines and chemokines, and consequently shaping the adaptive immune responses. Recent frontier studies have demonstrated
Huimin, Yan +2 more
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The CD94/NKG2 C-Type Lectin Receptor Complex
1998A multigene family of human Ig-SF receptors and members of the murine Ly49 C-type lectin family are involved in natural killer (NK) cell-mediated recognition of MHC class I molecules. The human CD94 glycoprotein covalently assembles with different C-type lectins of the NKG2 family.
M, López-Botet +5 more
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Screening for Ligands of C-Type Lectin-Like Receptors
2011In order to execute their immune functions, leukocytes interact with a broad range of cell types through cell surface receptors, such as those of the immunoglobulin and C-type lectin families, or indirectly through soluble factors. The characterization of activating and inhibitory counterparts of NK cell receptors on myeloid cells, as well as the ...
Elwira, Pyż, Gordon D, Brown
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C-type lectin receptors in tuberculosis: what we know
Medical Microbiology and Immunology, 2016Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), is recognized by a number of pathogen recognition receptors (PRRs), either soluble or predominantly expressed on the surface of various cells of innate and adaptive immunity.
Surabhi, Goyal +2 more
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Structural Aspects of C-Type Lectin Receptors
2016Numerous structural analyses (X-ray crystallography and NMR) of C-type lectin receptors (CLRs) have been performed, because CLRs are not only attractive as important molecules in immunity and infectious diseases but also as drug targets. In CLRs, high amino acid sequence similarity exists in the extracellular carbohydrate recognition domains (CRDs ...
Atsushi Furukawa +4 more
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C-type lectin receptors (CLRs)
Reactome - a curated knowledgebase of biological pathways, 2015openaire +1 more source
Transmembrane C-type lectin receptors in immunity
Вестник Сыктывкарского университета. Серия 2: Биология. Геология. Химия. Экология, 2021openaire +1 more source
Endogenous ligands for C‐type lectin receptors: the true regulators of immune homeostasis
Immunological Reviews, 2009Juan J García-Vallejo +1 more
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