Results 61 to 70 of about 131,185 (277)
Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy [PDF]
, 2015 Evasion of innate immune recognition is one of the key strategies for persistence of Helicobacter pylori, by virtue of its ability to modulate or escape the host innate immune receptors and signaling pathways. C-type lectin receptors (CLRs) predominantly
Ahmed, N +2 more
core +1 more source
From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans [PDF]
, 2009 Glycan epitopes of cellular glycoconjugates act as versatile biochemical signals (sugar coding). Here, we test the hypothesis that the common N-glycan modifications by core fucosylation and introduction of the bisecting N-acetylglucosamine moiety have ...
André, Sabine +4 more
core +1 more source
Inhibitory C-type lectin receptors in myeloid cells
Immunology Letters, 2011 C-type lectin receptors encoded by the natural killer gene complex play critical roles in enabling NK cell discrimination between self and non-self. In recent years, additional genes at this locus have been identified with patterns of expression that extend to cells of the myeloid lineage where many of the encoded inhibitory receptors have equally ...
Redelinghuys, Pierre, Brown, Gordon D
openaire +3 more sources
Insects, 2012 Pattern recognition receptors play an important role in insect immune defense. We cloned the β-1,3-glucan recognition protein, lectin-5 and C-type lectin 1 genes of Antheraea pernyi and examined the expression profiles of immune-stimulated pupae.
Wenli Li +4 more
doaj +1 more source
Frontiers in Immunology, 2023 Innate immune receptors that form complexes with secondary receptors, activating multiple signalling pathways, modulate cellular activation and play essential roles in regulating homeostasis and immunity. We have previously identified a variety of bovine
Angela Holder +10 more
doaj +1 more source
Signalling C-Type lectin receptors, microbial recognition and immunity [PDF]
, 2014 This work was supported in part by the Wellcome Trust, Medical Research Council (UK) and the University of Cape Town. J.C. Hoving is a Carnegie Corporation postdoctoral researcher at the University of Cape Town.
Brown, Gordon D +2 more
core +1 more source
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity [PDF]
Frontiers in Immunology, 2018 Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review,
Juan Tang +5 more
openaire +3 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Evolution of the C-Type Lectin-Like Receptor Genes of the DECTIN-1 Cluster in the NK Gene Complex
The Scientific World Journal, 2012 Pattern recognition receptors are crucial in initiating and shaping innate and adaptive immune responses and often belong to families of structurally and evolutionarily related proteins.
Susanne Sattler +2 more
doaj +1 more source
C‐type lectin‐like receptors on myeloid cells
Annals of Medicine, 2006 Host defence against pathogens requires the recognition of conserved microbial molecules, or 'pathogen-associated molecular patterns' (PAMPs), by their receptors termed 'pattern recognition receptors' (PRRs), represented most notably by toll-like receptors (TLRs) and C-type lectins.
Elwira, Pyz +3 more
openaire +2 more sources