Signalling C-type lectins in antimicrobial immunity. [PDF]
PLoS Pathogens, 2013 Since it was first proposed that the innate immune system could recognise conserved microbial-associated molecular patterns (or PAMPs) through inherited receptors expressed by the host (termed pattern recognition receptors, or PRRs), several families of PRRs have been discovered and characterised.
Rebecca A Drummond, Gordon D Brown
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C-type lectins and extracellular vesicles in virus-induced NETosis [PDF]
Journal of Biomedical Science, 2021 Dysregulated formation of neutrophil extracellular traps (NETs) is observed in acute viral infections. Moreover, NETs contribute to the pathogenesis of acute viral infections, including those caused by the dengue virus (DV) and severe acute respiratory ...
Pei-Shan Sung, Shie-Liang Hsieh
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C-type lectins in HIV-1 infection [PDF]
Retrovirology, 2011 Adaptive immune responses by dendritic cells (DCs) are controlled by pattern recognition receptors such as Toll-like receptors (TLRs) and C-type lectins. C-type lectins interact with carbohydrate structures on pathogens. Upon pathogen binding, C-type lectins trigger signaling pathways that induce specific cytokines to dictate T cell polarization. Thus,
Geijtenbeek Teunis BH
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C-Type Lectins Link Immunological and Reproductive Processes in Aedes aegypti [PDF]
iScience, 2020 Summary: Physiological trade-offs between mosquito immune response and reproductive capability can arise due to insufficient resource availability. C-type lectin family members may be involved in these processes.
Hsing-Han Li +9 more
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CD209 C-Type Lectins Promote Host Invasion, Dissemination, and Infection of Toxoplasma gondii [PDF]
Frontiers in Immunology, 2020 Toxoplasma gondii, the causative agent of toxoplasmosis and a major opportunistic parasite associated with AIDS, is able to invade host cells of animals and humans.
Olivia Adhiambo Njiri +8 more
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From Snake Venom’s Disintegrins and C-Type Lectins to Anti-Platelet Drugs [PDF]
Toxins, 2019 Snake venoms are attractive natural sources for drug discovery and development, with a number of substances either in clinical use or in research and development.
Philip Lazarovici +2 more
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Transmission-blocking antibodies against mosquito C-type lectins for dengue prevention. [PDF]
PLoS Pathogens, 2014 C-type lectins are a family of proteins with carbohydrate-binding activity. Several C-type lectins in mammals or arthropods are employed as receptors or attachment factors to facilitate flavivirus invasion.
Yang Liu +8 more
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Targeting the C-type Lectins-Mediated Host-Pathogen Interactions with Dextran [PDF]
Journal of Pharmacy & Pharmaceutical Sciences, 2014 Dextran, the α-1,6-linked glucose polymer widely used in biology and medicine, promises new applications. Linear dextran applied as a blood plasma substitute demonstrates a high rate of biocompatibility.
Sergey Pustylnikov +3 more
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Lectins with Potential for Anti-Cancer Therapy
Molecules, 2015 This article reviews lectins of animal and plant origin that induce apoptosis and autophagy of cancer cells and hence possess the potential of being developed into anticancer drugs. Apoptosis-inducing lectins encompass galectins, C-type lectins, annexins,
Xiuli Dan, Tzi Bun Ng
exaly +3 more sources
Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1. [PDF]
PLoS ONE, 2017 Phagocytosis by innate immune cells is an important process for protection against multiple pathologies and is particularly important for resistance to infection.
Naomi M Walsh +4 more
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