Results 31 to 40 of about 92,407 (159)

The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer

Frontiers in Pharmacology, 2020
Chemokines are a family of small, secreted cytokines which regulate a variety of cell functions. The C-X-C motif chemokine ligand 12 (CXCL12) binds to C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7). The interaction of
Yi Shi, David J. Riese, Jianzhong Shen
doaj   +1 more source

α1‐Adrenergic Receptors Function Within Hetero‐Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C‐X‐C motif) Receptor 4 in Vascular Smooth Muscle Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundRecently, we provided evidence that α1‐adrenergic receptors (ARs) in vascular smooth muscle are regulated by chemokine (C‐X‐C motif) receptor (CXCR) 4 and atypical chemokine receptor 3 (ACKR3). While we showed that CXCR4 controls α1‐ARs through
Lauren J. Albee, Jonathan M. Eby, Abhishek Tripathi, Heather M. LaPorte, Xianlong Gao, Brian F. Volkman, Vadim Gaponenko, Matthias Majetschak   +7 more
doaj   +1 more source

CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain [PDF]

, 2016
The roles of chemokine C-X-C motif ligand 12 (CXCL12) and its receptor chemokine C-X-C motif receptor 4 (CXCR4) reveal this chemokine axis as an emerging neuromodulator in the nervous system. In the peripheral and central nervous systems, both CXCL12 and
Cheung, CW, Chung, SK, Luo, X, Wang, XMA, Xia, Z   +4 more
core   +1 more source

Gene Expression Profiling of Peripheral Blood Mononuclear Cells in Type 2 Diabetes: An Exploratory Study

Medicina, 2022
Background and Objectives: Visceral obesity is associated with chronic low-grade inflammation that predisposes to metabolic syndrome. Indeed, infiltration of adipose tissue with immune–inflammatory cells, including ‘classical’ inflammatory M1 and anti ...
Hana M. A. Fakhoury, Muhammad Affan Elahi, Saud Al Sarheed, Mohammed Al Dubayee, Awad Alshahrani, Mahmoud Zhra, Arwa Almassri, Ahmad Aljada   +7 more
doaj   +1 more source

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer [PDF]

, 2013
An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis of why immunotherapy is ineffective in this human disease. Despite finding that PDA-bearing mice had cancer cell-specific CD8+ T cells, the mice, like human patients ...
Caballero, O. L., Chan, D. S., Connell, C. M., Deonarine, A., Fearon, D. T., Feig, C., Janowitz, T., Jodrell, D. I., Jones, J. O., Kraman, M., Roberts, E. W., Teichmann, S. A., Tuveson, D. A., Wells, R. J. B., Zhao, Q.   +14 more
core   +1 more source

Stromal Cell–Derived Factor-1/Chemokine (C-X-C Motif) Ligand 12 Stimulates Human Hepatoma Cell Growth, Migration, and Invasion [PDF]

Molecular Cancer Research, 2007
AbstractIn addition to their physiologic effects in inflammation and angiogenesis, chemokines are involved in cancer pathology. The aim of this study was to determine whether the chemokine stromal cell–derived factor 1 (SDF-1) induces the growth, migration, and invasion of human hepatoma cells.
Sutton, A., Friand, V., Brule-Donneger, S., Chaigneau, T., Ziol, M., Sainte-Catherine, O., Poire, A., Saffar, L., Kraemer, M., Vassy, J., Nahon, P., Salzmann, J. L., Gattegno, L., Charnaux, N.   +13 more
openaire   +3 more sources

Redox-Active Protein Thioredoxin-1 Administration Ameliorates Influenza A Virus (H1N1)-Induced Acute Lung Injury in Mice [PDF]

, 2013
Objectives: Influenza virus infections can cause severe acute lung injury leading to significant morbidity and mortality. Thioredoxin-1 is a redox-active defensive protein induced in response to stress conditions.
Abdel-Ghafar, Akaike, Akaike, Atkuri, Beck, Beckman, Callister, Callister, Cho, Choi, Fleming, Garozzo, Ghezzi, Hagau, Hashiba, Hofer, Hoshino, Ichiki, Ito, Kaimul Ahsan, Kasuno, Kato, Leaver, Matsui, Matsukawa, Mitsui, Nakamura, Nakamura, Nakamura, Ohashi, Ohta, Pasquini, Sato, Sato, Shi, Shioji, Suliman, Takagi, Tao, Todoroki, Tomofuji, Toyokuni, Toyokuni, Tsukahara, Uchide, Ueda, Xu, Yamada   +47 more
core   +1 more source

The biological role of the CXCL12/CXCR4 axis in esophageal squamous cell carcinoma

Cancer Biology & Medicine, 2021
Esophageal cancer is the eighth most common malignant tumor and the sixth leading cause of cancer-related death worldwide. Esophageal squamous cell carcinoma (ESCC) is the main histological type of esophageal cancer, and accounts for 90% of all cancer ...
Xianxian Wu, Hongdian Zhang, Zhilin Sui, Yang Wang, Zhentao Yu   +4 more
doaj   +1 more source

IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs [PDF]

, 2015
The series of events leading to tertiary lymphoid organ (TLO) formation in mucosal organs following tissue damage remain unclear. Using a virus-induced model of autoantibody formation in the salivary glands of adult mice, we demonstrate that IL-22 ...
Barone, Francesca, Bombardieri, Michele, Bowman, Simon, Buckley, Christopher, Cloake, Thomas, de la Luz Garcia-Hernandez, Maria, Dias De Campos, Joana, Fisher, Benjamin, Fouser, Lynette, Lucchesi, Davide, Luther, Sanjev A., Nayar, Saba, Pitzalis, Constantino, Randall, Troy D., Rangle-Moreno, Javier, Toellner, Kai-Michael, Withers, David, Zhang, Yang   +17 more
core   +1 more source

The primary growth of laryngeal squamous cell carcinoma cells in vitro is effectively supported by paired cancer-associated fibroblasts alone

Tumor Biology, 2017
Most primarily cultured laryngeal squamous cell carcinoma cells are difficult to propagate in vitro and have a low survival rate. However, in our previous work to establish a laryngeal squamous cell carcinoma cell line, we found that laryngeal cancer ...
Mei Wang, Chunping Wu, Yu Guo, Xiaojuan Cao, Wenwei Zheng, Guo-Kang Fan   +5 more
doaj   +1 more source