Results 21 to 30 of about 17,598 (187)

A guide to chemokines and their receptors [PDF]

, 2018
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A, Dyer DP, Garton KJ, Gupta SK, Hundelshausen P, Janssens R, Murphy PM, Sozzani S, Speck RF, Suan D, Woollard SM, Zheng Y   +11 more
core   +1 more source

xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity

Cell Reports, 2023
Summary: Obesity-mediated hypoxic stress underlies inflammation, including interferon (IFN)-γ production by natural killer (NK) cells in white adipose tissue. However, the effects of obesity on NK cell IFN-γ production remain obscure.
Hee-Hoon Kim, Young-Ri Shim, Ha Neul Kim, Keungmo Yang, Tom Ryu, Kyurae Kim, Sung Eun Choi, Min Jeong Kim, Chaerin Woo, Katherine Po Sin Chung, Song Hwa Hong, Hyemi Shin, Jae Myoung Suh, Youngae Jung, Geum-Sook Hwang, Won Kim, Seok-Hwan Kim, Hyuk Soo Eun, Je Kyung Seong, Won-Il Jeong   +19 more
doaj   +1 more source

Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia. [PDF]

, 2017
BackgroundThe CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including CLL.
Amaya-Chanaga, Carlos I, Amine, Ale-Ali, Castro, Januario E, Choi, Michael Y, Fantin, Valeria R, Gu, Yin, Hallin, Max, Huser, Nanni, Kashyap, Manoj K, Kipps, Thomas J, Kumar, Deepak, Lindquist, Kevin, Liu, Shu-Hui, Pernasetti, Flavia, Rassenti, Laura Z, Simmons, Brett, Smeal, Tod, Yafawi, Rolla, Zhang, Cathy   +18 more
core   +4 more sources

Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy [PDF]

, 2020
Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of studies have shown the beneficial effects of MSC-based therapies to treat different pathologies, including neurological disorders ...
Capilla González, Vivian, Gauthier, Benoit R., Hmadcha, Abdelkrim, Martín Montalvo, Alejandro, Soria Escoms, Bernat   +4 more
core   +1 more source

The Chemokine Receptor CXCR4 and c-MET Cooperatively Promote Epithelial-Mesenchymal Transition in Gastric Cancer Cells

Translational Oncology, 2018
The C-X-C motif chemokine receptor 4 (CXCR4) pathway can promote tumor metastasis but is dependent on cross talk with other signaling pathways. The MET proto-oncogene (c-MET) participates in metastasis and is highly expressed in gastric cancer.
Yu Cheng, Yongxi Song, Jinglei Qu, Xiaofang Che, Na Song, Yibo Fan, Ti Wen, Ling Xu, Jing Gong, Xiaoxun Wang, Chenlu Zhang, Xiujuan Qu, Yunpeng Liu   +12 more
doaj   +1 more source

Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway. [PDF]

, 2015
The CXCR4 receptor (Chemokine C-X-C motif receptor 4) is highly expressed in different hematological malignancies including chronic lymphocytic leukemia (CLL).
Ale-Ali, Amine, Amaya-Chanaga, Carlos I, Cardarelli, Pina M, Castro, Januario E, Choi, Michael Y, Cohen, Lewis J, Jones, Harrison, Kashyap, Manoj K, Kipps, Thomas J, Kuhne, Michelle R, Kumar, Deepak, Melo-Cardenas, Johanna, Rassenti, Laura Z, Sabbatini, Peter, Shelat, Suresh G   +14 more
core   +2 more sources

Differential expression of C-X-C motif chemokine ligand 12, CXCL12, in cancers of the breast.

, 2021
Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding C-X-C motif chemokine
openaire   +2 more sources

Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain [PDF]

, 2016
published_or_final_versio
Cheung, CW, Chung, SK, Luo, X, Pan, Z, Sun, LT, TAI, WL, Xia, Z   +6 more
core   +1 more source

Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development. [PDF]

, 2018
Integrin activation regulates adhesion, extracellular matrix assembly, and cell migration, thereby playing an indispensable role in development and in many pathological processes.
Fan, Zhichao, Gingras, Alexandre R, Ginsberg, Mark H, Lagarrigue, Frederic, Ley, Klaus, Sun, Hao   +5 more
core   +2 more sources

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands [PDF]

, 2019
Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form.
Aguilar-Pérez, Alexandra, Awad, Mohamed E., Eisa, Nada H., Elmansi, Ahmed M., Fulzele, Sadanand, Hamrick, Mark W., Herberg, Samuel, Hill, William D., Hussein, Khaled A., Isales, Carlos M., Kondrikov, Dmitry, McGee-Lawrence, Meghan E., Periyasamy-Thandavan, Sudharsan, Volkman, Brian F.   +13 more
core   +1 more source