Results 21 to 30 of about 117,459 (333)

Biological activities of C1 inhibitor [PDF]

Molecular Immunology, 2008
Broadly speaking, C1 inhibitor plays important roles in the regulation of vascular permeability and in the suppression of inflammation. Vascular permeability control is exerted largely through inhibition of two of the proteases involved in the generation of bradykinin, factor XIIa and plasma kallikrein (the plasma kallikrein-kinin system).
Pedro Mejia, Fengxin Lu, Alvin E. Davis
openaire   +3 more sources

C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation

Frontiers in Cellular Neuroscience, 2014
Traumatic brain injury (TBI) induces a strong inflammatory response which includes blood-brain barrier damage, edema formation and infiltration of different immune cell subsets.
Christiane eAlbert-Weissenberger, Stine eMencl, Michael K. Schuhmann, Irmak eSalur, Eva eGöb, Friederike eLangenhauser, Sarah eHopp, Nelli eHennig, Sven G Meuth, Sven G Meuth, Marc W. Nolte, Anna-Leena eSirén, Christoph eKleinschnitz   +12 more
doaj   +1 more source

Spectrum of diagnosis of hereditary angioedema: Seven case reports

Indian Journal of Allergy Asthma and Immunology, 2020
Hereditary angioedema (HAE) is a potentially life-threatening disorder, due to a mutation in complement one-inhibitor (C1-INH) gene, which blocks the activity of various components of complement – fibrinolytic and bradykinin control system.
P C Kathuria, Manisha Rai, Neelam Kathuria   +2 more
doaj   +1 more source

A National Survey of Hereditary Angioedema and Acquired C1 Inhibitor Deficiency in the United Kingdom [PDF]

, 2023
Background: Detailed demographic data on people with hereditary angioedema (HAE) and acquired C1 inhibitor deficiency in the United Kingdom are relatively limited.
Alachkar, Hana, Anantharachagan, Ariharan, Arkwright, Peter D, Bernatoniene, Jolanta, Bhole, Malini, Brown, Lindsay, Buckland, Matthew, Burns, Siobhan, Chopra, Charu, Coulter, Tanya, Darroch, James, Drewe, Elizabeth, Edmonds, Jillian, Ekbote, Anjali, El-Shanwany, Tariq, Elkhalifa, Shuayb, Garcez, Tomaz, Goddard, Sarah, Grosse-Kreul, Dorothea, Gurugama, Padmalal, Hackett, Scott, Hague, Rosie, Herriot, Richard, Herwadkar, Archana, Hughes, Stephen M, Jain, Rashmi, Jones, Laura, Kham Murng, Sai Hurng, Kiani-Alikhan, Sorena, Lear, Sara, Manson, Ania, McDermott, Elizabeth, Noorani, Sadia, Price, Arthur, Redenbaugh, Vyanka, Richter, Alex, Riordan, Andrew, Sargur, Ravishankar, Shackley, Fiona, Springett, Debbie, Steele, Cathal, Stichbury, Julia, Stroud, Catherine, Symons, Christine, Tarzi, Michael D, Thomas, Moira, Vijayadurai, Pavaladurai, Worth, Austen, Yong, Patrick F K   +48 more
core   +6 more sources

Optimum Use of Acute Treatments for Hereditary Angioedema: Evidence-Based Expert Consensus

Frontiers in Medicine, 2018
Acute treatment of hereditary angioedema due to C1 inhibitor deficiency has become available in the last 10 years and has greatly improved patients’ quality of life.
Hilary Longhurst
doaj   +1 more source

Hereditary angioedema: Diagnostic algorithm and current treatment concepts

Indian Dermatology Online Journal, 2021
Hereditary angioedema (HAE) is an uncommon disorder with a global prevalence of approximately 1 in 10,000 to 1 in 50,000 population. This disease is grossly underrecognized in India because of lack of awareness and/or lack of diagnostic facilities ...
Ankur Kumar Jindal, Anuradha Bishnoi, Sunil Dogra   +2 more
doaj   +1 more source

WAO guideline for the management of hereditary angioedema [PDF]

, 2012
Hereditary Angioedema (HAE) is a rare disease and for this reason proper diagnosis and appropriate therapy are often unknown or not available for physicians and other health care providers.
Aygören-Pürsün, Emel, Bork, Konrad, Bowen, Tom, Boysen, Henrik B., Craig, Timothy, Farkas, Henriette, Grumach, Anete, Katelaris, Constance H., Lockey, Richard, Longhurst, Hilary, Lumry, William, Magerl, Markus, Martinez-Saguer, Immaculada, Maurer, Marcus, Nast, Alexander, Pawankar, Ruby, Ritchie, Bruce, Zuraw, Bruce   +17 more
core   +1 more source

Risk of angioedema following invasive or surgical procedures in HAE type I and II : the natural history [PDF]

, 2013
Background: Hereditary angioedema (HAE), caused by deficiency in C1-inhibitor (C1-INH), leads to unpredictable edema of subcutaneous tissues with potentially fatal complications.
Aygören-Pürsün, Emel, Klingebiel, Thomas, Kreuz, Wolfhart, Martinez Saguer, Inmaculada, Schwabe, Dirk   +4 more
core   +1 more source

Mechanisms of C1-Inhibitor Deficiency

Immunobiology, 2002
C1 inhibitor (C1-Inh) is a protease inhibitor of the serpin family. It interacts and forms complexes with several serine proteases although not all these interactions were proved to be relevant in vivo. Based on studies in deficient patients, C1-Inh appears pivotal in regulating the activation of complement classical pathway and of contact system.
E. Pappalardo, L.C. Zingale, TERLIZZI, MARIA ADELAIDE, A. Zanichelli, A. Folcioni, M. Cicardi   +5 more
openaire   +3 more sources

Successful C1 inhibitor short-term prophylaxis during redo mitral valve replacement in a patient with hereditary angioedema

Journal of Cardiothoracic Surgery, 2010
Hereditary angioedema is characterized by sudden episodes of nonpitting edema that cause discomfort and pain. Typically the extremities, genitalia, trunk, gastrointestinal tract, face, and larynx are affected by attacks of swelling.
Coleman Suzanne, Bernstein Jonathan A, Bonnin Arturo J   +2 more
doaj   +1 more source