Results 61 to 70 of about 117,459 (333)

Glycosaminoglycans affect the interaction of human plasma kallikrein with plasminogen, factor XII and inhibitors [PDF]

, 2003
Human plasma kallikrein, a serine proteinase, plays a key role in intrinsic blood clotting, in the kallikrein-kinin system, and in fibrinolysis. The proteolytic enzymes involved in these processes are usually controlled by specific inhibitors and may be ...
Araujo, Mariana da Silva, Carmona, Adriana Karaoglanovic, Dietrich, Carl Peter, Gozzo, Andrezza Justino, Nader, Helena Bonciani, Nunes, V.a., Sampaio, C.a.m., Sampaio, Misako Uemura   +7 more
core   +1 more source

Laboratory testing for C1 inhibitor deficiency: a comparison of two approaches to C1 inhibitor function [PDF]

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2007
Background: C1 inhibitor deficiency may be hereditary or acquired. It is characterized by absent or poorly functioning C1 inhibitor. The disorder is rare, with prevalence estimated at 1/50,000. The very low incidence of the condition makes the sensitivity and specificity of assays used particularly important.
M M Gompels, Robert J Lock
openaire   +2 more sources

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Presence of C1-inhibitor polymers in a subset of patients suffering from hereditary angioedema. [PDF]

PLoS ONE, 2014
Hereditary angioedema (HAE) is a potentially life-threatening disease caused by mutations in the gene encoding the serine protease inhibitor (serpin) C1 inhibitor (C1-inh).
Daniel Elenius Madsen, Søren Hansen, Jørgen Gram, Anette Bygum, Christian Drouet, Johannes Jakobsen Sidelmann   +5 more
doaj   +1 more source

Delving into Vertebrate Serpins for Understanding their Evolution [PDF]

, 2009
The superfamily of serine proteinase inhibitors (serpins) is involved in an array of fundamental biological processes such as blood coagulation, cell differentiation, cell migration, complement activation, embryo implantation, fibrinolysis, angiogenesis,
Abhishek Kumar
core   +2 more sources

Potential Roles for C1 Inhibitor in Transplantation [PDF]

Transplantation, 2016
Complement is a major contributor to inflammation and graft injury. This system is especially important in ischemia-reperfusion injury/delayed graft function as well as in acute and chronic antibody-mediated rejection (AMR). The latter is increasingly recognized as a major cause of late graft loss, for which we have few effective therapies.
Melvin Berger, William M. Baldwin, Stanley C. Jordan   +2 more
openaire   +3 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Treatment of hereditary angioedema with plasma-derived C1 inhibitor

Therapeutics and Clinical Risk Management, 2008
Michael J Prematta, Tracy Prematta, Timothy J CraigSection of Allergy and Immunology, Penn State University, Milton S. Hershey Medical Center, PA, USABackground: Plasma-derived C1 inhibitor (C1-INH) concentrate is a treatment option for acute hereditary ...
Michael J Prematta, Tracy Prematta, Timothy J Craig   +2 more
doaj  

Oxidative stress markers in patients with hereditary angioedema

Archives of Medical Science, 2018
Introduction Hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) or with normal C1-INH is characterized by recurrent swellings due to uncontrolled production of vasoactive mediators, among which bradykinin (BK) is crucial. Through the binding and
Stefano R. Del Giacco, Davide Firinu, Paola Lucia Minciullo, Maria Pina Barca, Paolo Emilio Manconi, Gennaro Tartarisco, Mariateresa Cristani, Antonella Saija, Sebastiano Gangemi   +8 more
doaj   +1 more source

Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex

mBio, 2021
Complement, contact activation, coagulation, and fibrinolysis are serum protein cascades that need strict regulation to maintain human health. Serum glycoprotein, a C1 inhibitor (C1-INH), is a key regulator (inhibitor) of serine proteases of all the ...
Arun Dhillon, Justin C. Deme, Emily Furlong, Dorina Roem, Ilse Jongerius, Steven Johnson, Susan M. Lea   +6 more
doaj   +1 more source