Results 151 to 160 of about 1,608 (173)

In-depth quantitative proteomics analysis revealed C1GALT1 depletion in ECC-1 cells mimics an aggressive endometrial cancer phenotype observed in cancer patients with low C1GALT1 expression [PDF]

Cellular Oncology (Dordrecht), 2023
Background: Endometrial cancer (EC) is the most common cancer of the female reproductive organs. Despite the good overall prognosis of most low-grade ECs, FIGO I and FIGO II patients might experience tumor recurrence and worse prognosis.
Ana Montero Calle, Álvaro López-Janeiro, Rodrigo Barderas   +2 more
exaly   +8 more sources

Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy [PDF]

Kidney International, 2007
IgA nephropathy (IgAN) is a polygenic disorder and the precise role of genetic factors remains elusive. Increasing evidences have implicated the aberrant galactosylation of IgA1 molecules in the pathogenesis of IgAN.
H -Y Wang
exaly   +5 more sources

C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer [PDF]

Oncogene, 2018
Core 1 β1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation and is overexpressed in various human malignancies. However, its role in head and neck squamous cell carcinoma (HNSCC) remains unclear. Here we demonstrate that C1GALT1 expression is upregulated in HNSCC tumors and is associated with adverse ...
Min-Chuan Huang, Pei-Jen Lou, Hsin-Yi Wu
exaly   +4 more sources

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C1GALT1 polymorphisms are associated with Henoch–Schönlein purpura nephritis

Pediatric Nephrology, 2012
Henoch-Schönlein purpura nephritis (HSPN) is the most serious long-term complication of Henoch-Schönlein purpura and aberrant galactosylation of IgA1 plays a role in its development. However, the precise role of genetic factors contributing to the abnormal IgA1 galactosylation remains unknown.In order to examine the effects of C1GALT1 gene encoding ...
Peiwei Zhao
exaly   +3 more sources

Genetic variant of C1GalT1 contributes to the susceptibility to IgA nephropathy

Journal of Nephrology, 2009
Abstract Background: IgA nephropathy (IgAN) is a common form of primary glomerulonephritis characterized by diffuse glomerular mesangial IgA1 deposition that leads to mesangial proliferation and chronic glomerular inflammation. Analyses of serum IgA1 from IgAN patients revealed an abnormal galactosylation of the O-linked carbohydrate ...
Pirulli D, Crovella S, Ulivi S, Zadro C, Bertok S, RENDINE, Sabina, Scolari F, Foramitti M, Ravani P, ROCCATELLO, Dario, Savoldi S, Cerullo G, Lanzilotta SG, Bisceglia L, Zelante L, Floege J, Alexopoulos E, Kirmizis D, Ghiggeri GM, Frascà G, Schena FP, AMOROSO, Antonio, European IgAN Consortium   +22 more
openaire   +6 more sources

C1GALT1 Seems to Promote In Vitro Disease Progression in Ovarian Cancer

International Journal of Gynecological Cancer, 2017
Aberrant glycosylation affects many cellular properties in cancers. The core 1 β1,3-galactosyltransferase (C1GALT1), an enzyme that controls the formation of mucin-type O-glycans, has been reported to regulate hepatocellular and mammary carcinogenesis. This study aimed to explore the role of C1GALT1 in ovarian cancer.C1GALT1 expression was assessed in ...
Chih-Hsing, Chou, Miao-Juei, Huang, Ying-Yu, Liao, Chi-Hau, Chen, Min-Chuan, Huang   +4 more
openaire   +2 more sources

C1GALT1 Enhances Proliferation of Hepatocellular Carcinoma Cells via Modulating MET Glycosylation and Dimerization [PDF]

Cancer Research, 2013
Abstract Altered glycosylation is a hallmark of cancer. The core 1 β1,3-galactosyltransferase (C1GALT1) controls the formation of mucin-type O-glycans, far overlooked and underestimated in cancer. Here, we report that C1GALT1 mRNA and protein are frequently overexpressed in hepatocellular carcinoma tumors compared with nontumor liver ...
Rey-heng Hu, Min-Chuan Huang
exaly   +3 more sources

Anti‐C1GALT1 Autoantibody Is a Novel Prognostic Biomarker for Patients With Head and Neck Cancer

The Laryngoscope, 2020
ObjectivesThe objective of this study is to determine the value of the anti‐ glycoprotein‐N‐acetylgalactosamine 3‐beta‐galactosyltransferase 1 (C1GALT1) autoantibody as a biomarker for distant metastasis and good response to immune checkpoint inhibitors in patients with head and neck squamous cell carcinoma (HNSCC).MethodsIn this retrospective study ...
Mei‐Chun Lin, Min‐Chuan Huang, Pei‐Jen Lou   +2 more
openaire   +2 more sources

A study on the association between C1GALT1 polymorphisms and the risk of Henoch–Schönlein purpura in a Chinese population

Rheumatology International, 2013
Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis of childhood. The molecular etiology of HSP is not well understood. The purpose of this study is to investigate the association between polymorphisms in C1GALT1 gene and the risk of HSP in a Chinese population.
Zhihong Ma
exaly   +3 more sources

Abstract 1400: C1GALT1 regulates malignant phenotypes of cholangiocarcinoma cells

Cancer Research, 2019
Abstract Identifying molecular targets for cholangiocarcinoma is an urgent need to overcome the treatment failure and death from cancer cell invasion and metastasis. Core 1 β1,3-galactosyltransferase (C1GALT1) has been documented as the key enzyme in morphogenesis and cellular adhesion, for it adds galactose to form Gal-GalNAc-Ser/Thr
Po-Da Chen, Ai-An Chang, Min-Chuan Huang, Yao-Ming Wu   +3 more
openaire   +1 more source