Results 161 to 170 of about 1,608 (173)

Clinic implication of MUC1 O-glycosylation and C1GALT1 in esophagus squamous cell carcinoma

Science China Life Sciences, 2018
Esophagus squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumors in the world. Our previous data demonstrates that oncoprotein MUC1 is related with metastasis and poor outcome of ESCC. However, alteration of MUC1 in ESCC remains unclear.
Yuming, Wang, Xiaodong, Liao, Qing, Ye, Lei, Huang   +3 more
openaire   +2 more sources

C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes

Blood, 2013
Key PointsMucin-type O-glycans are required for terminal differentiation of megakaryocytes and platelet production. The expression of GPIbα protein is strongly reduced in O-glycans–defective megakaryocytes and platelets.
Takashi, Kudo, Takashi, Sato, Kozue, Hagiwara, Yukinori, Kozuma, Takashi, Yamaguchi, Yuzuru, Ikehara, Michito, Hamada, Ken, Matsumoto, Masatsugu, Ema, Soichiro, Murata, Nobuhiro, Ohkohchi, Hisashi, Narimatsu, Satoru, Takahashi   +12 more
openaire   +2 more sources

C1GALT1 high expression enhances the progression of glioblastoma through the EGFR-AKT/ERK cascade

Cellular Signalling
Core1 β1,3-galactosyltransferase (C1GALT1) is an essential glycotransferase controlling the elongation of GalNAc-type O-glycosylation and its altered expression contributes tumor progression in various cancers. However, the mechanism how C1GALT1 influences gliomas remains unclear.
Surui Lu, Shigang Shan
exaly   +3 more sources

The Association of rs1047763 and rs1008898 of C1GALT1 with IgA Nephropathy Risk: A Global Meta-Analysis

Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2017
IgA nephropathy (IgAN) is a globally common primary glomerulonephritis characterized by an elevated level of serum IgA and immune complex deposition in the mesangial area. In the serum of patients with IgAN, the hinge region of IgA1 immunoglobulin contains aberrantly glycosylated O-glycans deficient in galactose, which is normally added to the core 1 O-
Ruili, Nie, Guixue, Cheng, Jin, Zhang, Yu, Dong, Chen, Wang, Jianhua, Liu, Xiaosong, Qin   +6 more
openaire   +2 more sources

P0247 : C1GAlT1 is overexpressed in cholangiocarcinoma and C1GAlT1 knockdown inhibits malignant behaviors of cholangiocarcinoma cells

Journal of Hepatology, 2015
M.-C. Huang, M.-J. Huang, Y.-M. Wu
openaire   +1 more source

Anti-C1GALT1 Autoantibody Is a Novel Prognostic Biomarker for Patients With Head and Neck Cancer

Laryngoscope, 2021
Min-Chuan Huang, Pei-Jen Lou, Mei-Chun Lin   +2 more
exaly  

SLC35A2 deficiency reduces protein levels of core 1 β-1,3-galactosyltransferase 1 (C1GalT1) and its chaperone Cosmc and affects their subcellular localization

Biochimica Et Biophysica Acta - Molecular Cell Research, 2023
Mariusz Olczak, Dorota Maszczak-Seneczko, Wojciech Wiertelak   +2 more
exaly  

Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice

Gastroenterology, 2018
Moorthy Palanimuthu Ponnusamy, Surinder K Batra, Srikanth Barkeer   +2 more
exaly  

Biological Functions of C1GalT1 and Mucin-Type O-Glycans

2014
Kirk Bergstrom, Jianxin Fu, Lijun Xia
openaire   +1 more source

C1GALT1-Mediated O-Glycosylation: A Critical Driver of RTK Signaling and Therapeutic Resistance in HNSCC

Background: Aberrant glycosylation is increasingly recognized as a hallmark of cancer, influencing receptor function and downstream signaling. Core 1 β1,3-galactosyltransferase (C1GALT1), a key enzyme in mucin-type O-glycosylation, has emerged as a regulator of receptor tyrosine kinase (RTK) activity.
openaire   +1 more source