Results 111 to 120 of about 57,775 (215)

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Volume 78, Issue 3, Page 548-557, March 2026.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

Pediatric Non‐Lupus Full House Nephropathy: Case Report and Review of Literature

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Lupus nephritis is a severe manifestation of systemic lupus erythematosus (SLE) typically characterized by glomerular “full‐house” immunofluorescence. However, non‐lupus nephropathies may occasionally exhibit similar patterns, creating diagnostic uncertainty.
Mohammad Firoz Anjum, Suraj Sah, Inesh Khanal, Sharmila Gainju, Sri Ram K.C.   +4 more
wiley   +1 more source

Double‐Filtration Plasmapheresis Versus Efgartigimod for Generalized Myasthenia Gravis: Severity‐Stratified Benefits in a Prospective Observational Multicenter Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Both Double‐Filtration Plasmapheresis (DFPP) and efgartigimod effectively treat acute exacerbations of generalized myasthenia gravis (gMG), with efficacy rising across successive sessions. In moderate‐to‐severe gMG, 3/5‐session DFPP outperformed 4‐infusion efgartigimod, while efficacy was comparable in mild cases.
Kan Wang, Hanyu Xin, Mengze Zhang, Qiuju Li, Yanan Wu, Xia Li, Jing Peng, Chong Xie, Xiajun Zhou, Li Gao, Xuzhong Pei, Yiwei Yang, Yuhui Wang, Yuan Zhong, Lu Zhang, Desheng Zhu, Yangtai Guan   +16 more
wiley   +1 more source

Preclinical advances in antibodies against N‐terminal Aβ4‐x species for Alzheimer's disease and cerebral amyloid angiopathy

Ibrain, Volume 12, Issue 1, Page 52-64, Spring 2026.
This review provides an update on monoclonal and polyclonal antibodies developed to specifically target amyloid beta (Aβ) truncated species starting at residue phenylalanine 4 (Aβ4‐x) in Alzheimer's disease and cerebral amyloid angiopathy preclinical studies (in vitro and in vivo models).
Maria Luisa Valle, Donatello Arienzo
wiley   +1 more source

C1Q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity but Low Sensitivity When Predicting Flow Crossmatch

Journal of Transplantation, 2016
The aim of the present study was to describe the association of positive flow cross match (FXM) and C1q-SAB. Methods. In this observational, cross-sectional, and comparative study, patients included had negative AHG-CDC-XM and donor specific antibodies ...
José M. Arreola-Guerra, Natalia Castelán, Adrián de Santiago, Adriana Arvizu, Norma Gonzalez-Tableros, Mayra López, Isaac Salcedo, Mario Vilatobá, Julio Granados, Luis E. Morales-Buenrostro, Josefina Alberú   +10 more
doaj   +1 more source

The Role of Extracellular Vesicles in Transient Ischaemic Attacks and Ischaemic Stroke: A Systematic Review

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
Both transient ischaemic attack (TIA) and ischaemic stroke lead to an increase in individual cellular‐derived populations of extracellular vesicles (EVs), including endothelial, platelet and leukocyte derived. These EVs have downstream roles in the pathophysiological events associated with TIA and stroke, including dysregulated inflammation and ...
Rebecca Marie Raven, Philip Eurig James, Keith Morris, Jessica Olivia Williams   +3 more
wiley   +1 more source

Clinical Application of Peripheral Blood Biomarkers for Solid Tumors

MedComm, Volume 7, Issue 3, March 2026.
Peripheral blood biomarkers provide a minimally invasive, dynamic, and potentially more accurate means to obtain a comprehensive tumor profile. Technologies for detecting them are advancing, and with the help of artificial intelligence, they are being used more and more often for cancer diagnosis, prognostic assessment, and therapeutic monitoring ...
Xinru Tu, Mengyan Tu, Junfen Xu
wiley   +1 more source

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1622-1637, March 2026.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source