Results 111 to 120 of about 70,452 (309)

Emerging Roles of Complement Protein C1q in Neurodegeneration

Aging and Disease, 2019
The innate immune system is an ancient and primary component system that rapidly reacts to defend the body against external pathogens. C1 is the initial responder of classical pathway of the innate immune system.
Kyoungjoo Cho
semanticscholar   +1 more source

Systemic lupus erythematosus and C1q: A quantitative ELISA for determining C1q levels in serum [PDF]

Biotechnology Journal, 2009
AbstractThe authors would like to acknowledge the National Institutes of Health for funding (grant number 5R01AR053734).
Anil D'Souza, Anil D'Souza, Anil D'Souza, Biji T. Kurien, Biji T. Kurien, R. Hal Scofield, R. Hal Scofield, R. Hal Scofield, Skyler P. Dillon   +8 more
openaire   +3 more sources

Invasive Meningococcal Disease in a Patient With Complement 7 Deficiency

Journal of General and Family Medicine, EarlyView.
ABSTRACT Neisseria meningitidis can cause invasive meningococcal disease (IMD). Individuals with primary complement deficiencies are at a higher risk of developing IMD. However, cases of IMD associated with complement deficiency have rarely been reported in Japan.
Hiroaki Nishioka, Kazuki Maegawa, Shigeo Hara   +2 more
wiley   +1 more source

On the effect of preferential sampling in spatial prediction

, 2012
The choice of the sampling locations in a spatial network is often guided by practical demands. In particular, many locations are preferentially chosen to capture high values of a response, for example, air pollution levels in environmental monitoring ...
Banerjee, Banerjee, Chakraborty, Cocchi, Cressie, Dawid, Diggle, Diggle, Hooten, Illian, Latimer, Lee, Lewis, Müller, Nychka, Pati, Pilz, Sahu, Sahu, Sheppard, Theobald, Xia   +21 more
core   +1 more source

Cooperation of C1q Receptors and Integrins in C1q-Mediated Endothelial Cell Adhesion and Spreading [PDF]

The Journal of Immunology, 2002
Abstract The interaction of C1q with endothelial cells elicits a multiplicity of biologic responses. Although these responses are presumed to be mediated by the interaction of C1q with endothelial cell surface proteins, the identity of the participants is not known.
Ellinor I.B. Peerschke, Marcia G. Tonnesen, Berhane Ghebrehiwet, Xiaodong Feng   +3 more
openaire   +3 more sources

Endogenous complement-activating IgM is not required for primary antibody responses but promotes plasma cell differentiation and secondary antibody responses to a large particulate antigen in mice

Frontiers in Immunology
Lack of complement factor C1q of the classical pathway results in severely impaired primary antibody responses. This is a paradox because antibodies, especially IgM, are the most efficient activators of the classical pathway and very little specific IgM ...
Anna-Karin E. Palm, Annika Westin, Diyar Ayranci, Birgitta Heyman   +3 more
doaj   +1 more source

Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas

Frontiers in Immunology, 2019
C1q is the first subcomponent of the classical pathway of the complement system and belongs to the C1q/Tumor Necrosis Factor superfamily. C1q can perform a diverse range of immune and non-immune functions in a complement-dependent as well as -independent
A. Mangogna, C. Agostinis, D. Bonazza, B. Belmonte, P. Zacchi, Gabriella Zito, A. Romano, F. Zanconati, G. Ricci, U. Kishore, R. Bulla   +10 more
semanticscholar   +1 more source

Causal Link and Shared Biomarkers Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis

Med Research, EarlyView.
ABSTRACT This study investigates the causal relationship between rheumatoid arthritis (RA) and idiopathic pulmonary fibrosis (IPF), aiming to identify shared biomarkers between the two conditions. Utilizing bidirectional Mendelian randomization (MR), we assessed causality by analyzing genome‐wide association study (GWAS) data from European cohorts ...
Xixi Pan, Chunhui Jiang, Jiani Chen, Tong Sun, Xianwei Wang, Jiaxi Chen   +5 more
wiley   +1 more source

Prognostic Implications of the Complement Protein C1q in Gliomas

Frontiers in Immunology, 2019
The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis.
A. Mangogna, B. Belmonte, C. Agostinis, P. Zacchi, D. Iacopino, A. Martorana, V. Rodolico, D. Bonazza, F. Zanconati, U. Kishore, R. Bulla   +10 more
semanticscholar   +1 more source

TREM2 Downregulation Disrupts Microglial Function and Synaptic Pruning Through RA/RARα Signaling: Mechanisms Underlying Autism‐Like Behaviors

Pediatric Discovery, EarlyView.
Downregulation of TREM2 induces autism‐like behaviors in healthy rats by impairing microglial function and triggering aberrant synaptic pruning. RA/RARα signaling pathway modulates alterations in TREM2 expression. Serum sTREM2 levels correspond to alterations in brain TREM2 expression.
Min Lu, Kexin Bai, Yali Bai, Yuan Miao, Tingjiao Zhao, Yi Yang, Jie Chen, Ting Yang, Tingyu Li, Hua Wei   +9 more
wiley   +1 more source