Results 161 to 170 of about 68,566 (325)

Low Molecular Weight C1q-Precipitins in Hypocomplementemic Vasculitis-Urticaria Syndrome: Partial Purification and Characterization as Immunoglobulin [PDF]

, 1978
Robert J. Marder, Frank X. Burch, Frank R. Schmid, Chester R. Zeiss, H Gewurz   +4 more
openalex   +1 more source

Interaction of C1q With Pentraxin 3 and IgM Revisited: Mutational Studies With Recombinant C1q Variants

Frontiers in Immunology, 2019
Pentraxins and complement defense collagens are soluble recognition proteins that sense pathogens and altered-self elements, and trigger immune responses including complement activation.
I. Bally, A. Inforzato, Fabien Dalonneau, M. Stravalaci, B. Bottazzi, C. Gaboriaud, N. Thielens   +6 more
semanticscholar   +1 more source

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, EarlyView.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

Binding of von Willebrand Factor to Complement C1q Decreases the Phagocytosis of Cholesterol Crystals and Subsequent IL-1 Secretion in Macrophages

Frontiers in Immunology, 2019
Complement C1q, the initiation molecule of the classical pathway, exerts various immunomodulatory functions independent of complement activation. Non-classical functions of C1q include the clearance of apoptotic cells and cholesterol crystals (CC), as ...
Claudia Donat, Sophia Thanei, Marten Trendelenburg, Marten Trendelenburg   +3 more
doaj   +1 more source

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Molecular Neurodegeneration, 2018
The role of the alternative complement pathway and its mediation by retinal microglia and macrophages, is well-established in the pathogenesis of Age-Related Macular Degeneration (AMD).
Haihan Jiao, Matt Rutar, Nilisha Fernando, T. Yednock, S. Sankaranarayanan, Riemke Aggio‐Bruce, J. Provis, R. Natoli   +7 more
semanticscholar   +1 more source

Experimental and Computational Insights into the Structural Dynamics of the Fc Fragment of IgG1 Subtype from Biosimilar VEGF‐Trap

Small Structures, EarlyView.
The constant fragment (Fc) of the immunoglobulin G1 (IgG1) subtype is a widely used scaffold for designing advanced therapeutics. Herein, together with the integration of experimental and computational techniques, this study reveals the structural dynamics of the N‐glycan‐bound Fc fragment of IgG1 from VEGF‐Trap, providing a new insight into enhancing ...
Ebru Destan, Engin Turkut, Alper Aldeniz, Jungmin Kang, Takehiko Tosha, Makina Yabashi, Baris Yilmaz, Ahmet Can Timucin, Hiroaki Matsuura, Yoshiaki Kawano, Irfan Cinkaya, Hasan DeMirci   +11 more
wiley   +1 more source

C1Q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity but Low Sensitivity When Predicting Flow Crossmatch

Journal of Transplantation, 2016
The aim of the present study was to describe the association of positive flow cross match (FXM) and C1q-SAB. Methods. In this observational, cross-sectional, and comparative study, patients included had negative AHG-CDC-XM and donor specific antibodies ...
José M. Arreola-Guerra, Natalia Castelán, Adrián de Santiago, Adriana Arvizu, Norma Gonzalez-Tableros, Mayra López, Isaac Salcedo, Mario Vilatobá, Julio Granados, Luis E. Morales-Buenrostro, Josefina Alberú   +10 more
doaj   +1 more source

Amino acid sequence of the N-terminal forty-two amino acid residues of the C chain of subcomponent C1q of the first component of human complement [PDF]

, 1977
K.B.M. Reid
openalex   +1 more source

Age‐Related Complement C3 Drives Memory Impairments and Associated Neuropathologies in a Mouse Model

Aging Cell, EarlyView.
Age‐related complement C3 elevation induces memory impairments and neuropathology by dysregulating astrocytic insulin signaling and triggering mitochondrial dysfunction. Critically, antibody blockade of C3 in mouse brain tissue effectively reversed learning and memory deficits in mice, demonstrating that targeting C3 is a promising therapeutic strategy.
Miaomiao Du, Yujia Wang, Xinyuan Wang, Yifei Liu, Fuchuan Xiao, Jing Zhang, Xia Meng, Kunhe Ma, Na Wu, Baian Chen, Jing Lu   +10 more
wiley   +1 more source

On the Interaction of Rabbit C1q with Sheep and Rabbit Immune Complexes [PDF]

, 1979
Paul A. Liberti, Richard D. Baillie, Kathleen F. Milligan, Dulcie M. Bausch   +3 more
openalex   +1 more source