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C1q, antibodies and anti-C1q autoantibodies
Molecular Immunology, 2015The complement system has long been known for its role in combating infections. More recently the complement system is becoming increasingly appreciated for its role in processes that range from waste transport, immune tolerance and shaping of the adaptive immune response.
Beurskens, F.J. +2 more
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C1q-binding proteins and C1q receptors
Current Opinion in Immunology, 1999Aggregated or immobilized complement C1q induces cellular responses in many different cell types. C1q-induced cellular responses may be involved in host defense and in protection against autoimmunity because C1q-deficient humans have infectious complications and a very high incidence of autoimmune disease.
A, Nicholson-Weller, L B, Klickstein
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C1q binding and C1q deviation assays using enzyme labelled C1q
Journal of Immunological Methods, 1984Methods for the enzyme labelling of C1q are described. The C1q conjugates have been incorporated into suitably modified C1q deviation and C1q binding assays for circulating immune complexes. These assays show the expected high positivity rate in sera from patients with systemic lupus erythematosus.
G W, Smith, M J, Myles, I J, Simpson
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RAGE binds C1q and enhances C1q-mediated phagocytosis
Cellular Immunology, 2012RAGE, the multiligand receptor of the immunoglobulin superfamily of cell surface molecules, is implicated in innate and adaptive immunity. Complement component C1q serves roles in complement activation and antibody-independent opsonization. Using soluble forms of RAGE (sRAGE) and RAGE-expressing cells, we determined that RAGE is a native C1q globular ...
Wanchao, Ma +5 more
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2019
Antibodies to components of the innate immune system are frequently detected in the sera of patients with systemic lupus erythematosus (SLE). Among these are antibodies against various components of the complement system. Antibodies to C1q have drawn particular attention as they have been suggested to be involved in the pathogenesis of lupus nephritis ...
De Leeuw, Karina, Kallenberg, Cees G.M.
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Antibodies to components of the innate immune system are frequently detected in the sera of patients with systemic lupus erythematosus (SLE). Among these are antibodies against various components of the complement system. Antibodies to C1q have drawn particular attention as they have been suggested to be involved in the pathogenesis of lupus nephritis ...
De Leeuw, Karina, Kallenberg, Cees G.M.
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Autoimmunity Reviews, 2008
Autoantibodies to complement components are associated with various diseases. Anti-C1q antibodies are present in all patients with hypocomplementemic urticarial vasculitis, but also, with varying prevalence, in other conditions. In SLE, these antibodies are neither sensitive nor specific for this condition.
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Autoantibodies to complement components are associated with various diseases. Anti-C1q antibodies are present in all patients with hypocomplementemic urticarial vasculitis, but also, with varying prevalence, in other conditions. In SLE, these antibodies are neither sensitive nor specific for this condition.
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Pediatric Nephrology, 2005
C1q nephropathy (C1qNP) is a peculiar form of glomerulonephritis characterized by mesangial immunoglobulin and complement deposits, predominantly C1q, with no evidence of systemic lupus erythematosus. We describe the incidence, manifestation, histopathologic findings, follow-up, treatment and outcome of C1qNP.
Tanja, Kersnik Levart +5 more
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C1q nephropathy (C1qNP) is a peculiar form of glomerulonephritis characterized by mesangial immunoglobulin and complement deposits, predominantly C1q, with no evidence of systemic lupus erythematosus. We describe the incidence, manifestation, histopathologic findings, follow-up, treatment and outcome of C1qNP.
Tanja, Kersnik Levart +5 more
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Macrophage C1q: characterization of a membrane form of C1q and of multimers of C1q subunits.
The Journal of Immunology, 1987Abstract It has been shown recently that C1q, a subcomponent of the first component of the classical complement pathway, is synthesized by macrophages and that endogenous C1q is detectable on the macrophage membrane. In this report, we demonstrate that membrane-associated C1q, which contains the A, B, and C chains of C1q ...
H, Martin, H P, Heinz, K, Reske, M, Loos
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Platelet C1q receptor interactions with collagen- and C1q-coated surfaces.
The Journal of Immunology, 1990Abstract We recently described specific binding sites for C1q on human blood platelets. Structural similarities between the amino-terminal of C1q and collagen have suggested that receptors for both molecules on platelets might be the same.
E I, Peerschke, B, Ghebrehiwet
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