Results 11 to 20 of about 30,787 (208)
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Frontiers in Immunology, 2014 The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses as well as an essential homeostatic role in the clearance of damaged self-antigens.
Julia A Sharp +5 more
doaj +1 more source
CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes [PDF]
Iranian Journal of Immunology, 2019 Background: CD93 has originally been known as a C1q receptor, and many studies have demonstrated that CD93 is expressed on hematopoietic stem cells, B cell progenitors, myeloid and monocytic cells.
Shohreh Fakhari +4 more
doaj +1 more source
Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization [PDF]
Frontiers in Immunology, 2014 Complement is a critical system of enzymes, regulatory proteins, and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions including infectious disease and autoimmunity.
Bohlson, Suzanne S. +4 more
openaire +3 more sources
SLE: Novel Postulates for Therapeutic Options
Frontiers in Immunology, 2020 Genetic deficiency in C1q is a strong susceptibility factor for systemic lupus erythematosus (SLE). There are two major hypotheses that potentially explain the role of C1q in SLE.
Kinga K. Hosszu +3 more
doaj +1 more source
Frontiers in Oncology, 2015 The immune system protects against disease, but may aberrantly silence immunity against altered self, with consequent development of malignancies. Among the components of the endoplasmic reticulum (ER), important in immunity, is calreticulin (CRT) that ...
GALIA eRAMIREZ-TOLOZA +4 more
doaj +1 more source
Hepatology Communications, 2022 Complement complex 1 subunit q (C1q) has multiple functions, including cell migration, in addition to its traditional complement‐activating effect. Research shows C1q is a ligand for frizzled receptors (FZDs).
Akiko Eguchi +10 more
doaj +1 more source
The human C1q globular domain: Structure and recognition of non immune self ligands
Frontiers in Immunology, 2012 C1q, the ligand binding unit of the C1 complex of complement, is a pattern recognition molecule with the unique ability to sense an amazing variety of targets, including a number of altered structures from self, such as apoptotic cells.
Christine eGaboriaud +3 more
doaj +1 more source
The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2
Molecular Medicine, 2021 Background C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types.
Ria Aryani Hayuningtyas +9 more
doaj +1 more source
C1q and central nervous system disorders
Frontiers in Immunology, 2023 C1q is a crucial component of the complement system, which is activated through the classical pathway to perform non-specific immune functions, serving as the first line of defense against pathogens.
Wenjie Zhang +3 more
doaj +1 more source