Results 11 to 20 of about 37,422 (167)

Cloning expression and characterisation of the globular head regions of mouse CIQ [PDF]

, 2014
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel UniversityThe classical pathway of complement system, activated by immune complexes, involves binding of globular heads of C1q to the Fc regions of aggregated IgG or ...
Shastri, Abhishek
core   +7 more sources

scRNA-Seq in Gastric Cancer Reveals Macrophage-Derived C1q as a Diagnostic Marker. [PDF]

Cancer Sci
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Gong S, Zhao Y, Yang S, Liu T, Li C, Zhou Y, Liang G.   +6 more
europepmc   +2 more sources

The Comprehensive Live Cell-Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xu X, Ding J, Du Y, Luo G, Li J, Liu R, Xu X, Li X, Li M, Jiang W, Yang C.   +10 more
europepmc   +2 more sources

Autoantibodies against complement C1q in systemic lupus erythemathosus [PDF]

, 2008
Complement and C1q, the first component of the classical pathway of activation of the complement system, are considered to be involved in the pathogenesis of systemic lupus erythematosus (SLE), a systemic autoimmune disease.
Bigler, Cornelia
core   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes [PDF]

, 2018
Poly(2-methyl-2-oxazoline) (PMOXA) is an alternative promising polymer to poly(ethylene glycol) (PEG) for design and engineering of macrophage-evading nanoparticles (NPs).
Lubian, Elisa, Giorgio Arrigoni (222174), Dmitri Simberg, Chen, Fangfang, Gabrielli, Luca, Wu, Linping, Polverino de Laureto, Patrizia, Tavano, Regina, Mancin, Fabrizio, Elisa Lubian, Morgese, Giulia, Giorgio Arrigoni, Fangfang Chen, Benetti, Edmondo Maria, Luca Gabrielli, Emanuele Papini (344065), Alessandra Geffner-Smith (5264735), Giulia Morgese (1611211), Silvia Visentin, Seyed Moein Moghimi, Linping Wu, Fedeli, Chiara, Regina Tavano (344061), Moghimi, Seyed Moein, Fabrizio Mancin (1534513), Papini, Emanuele, Regina Tavano, Edmondo M. Benetti, Silvia Visentin (3492620), Elisa Lubian (2263786), Fabrizio Mancin, Geffner-Smith, Alessandra, Chiara Fedeli, Edmondo M. Benetti (1513708), Arrigoni, Giorgio, Giulia Morgese, Fangfang Chen (302428), Seyed Moein Moghimi (625107), Linping Wu (5264729), Alessandra Geffner-Smith, Patrizia Polverino De Laureto (5264738), Dmitri Simberg (389013), Patrizia Polverino De Laureto, Visentin, Silvia, Simberg, Dmitri, Luca Gabrielli (1662952), Chiara Fedeli (5264732), Emanuele Papini   +47 more
core   +3 more sources

Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model. [PDF]

Glia
Young adult deletion of microglial C1q reduced engulfment of Vglut1+ synapses and mitigated spatial cognitive deficits at 10 months of age in the amyloidopathy Arctic mouse model of AD. Neither fibrillar amyloid plaques nor soluble or insoluble Aβ levels in the hippocampus were affected by young adult microglial loss of C1q despite reduced phagocytosis
Petrisko TJ, Chu SH, Gomez-Arboledas A, Zhang B, Tenner AJ.   +4 more
europepmc   +2 more sources

Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance [PDF]

, 2010
Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses.
Cook, T, Derbyshire, Katy, Dyson, Julian, Cook, Terence, Chai, JG, Coe, D, Scott, Diane, Dumitriu, IE, Baruah, Paramita, Coe, David, Dumitriu, Ingrid E; id_orcid, Dyson, J, Baruah, P, Derbyshire, K, Simpson, Elizabeth, Botto, Marina, Addey, C, Scott, D, Addey, Caroline, Botto, M, Chai, Jian-Guo, Simpson, E   +21 more
core   +1 more source

Serum C1q as a Novel Predictive Biomarker for Postoperative Delirium After Acute Type A Aortic Dissection. [PDF]

Immun Inflamm Dis
ABSTRACT Background This study aimed to evaluate the predictive value of C1q (complement activation regulatory factor) for the occurrence of postoperative delirium (POD) following surgery for acute aortic dissection. Methods We prospectively included patients undergoing surgery for aortic dissection. Serum levels of C1q were measured preoperatively and
Wang J, Jiang Y, Liu W, Wang Y, Lu S, Zhu J, Cai X, Tian Y, Cheng Y, Wang D, Xue Y.   +10 more
europepmc   +2 more sources

Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells [PDF]

, 2014
Bradykinin (BK) is one of the most potent vasodilator agonists known and belongs to the kinin family of proinflammatory peptides. BK induces its activity via two G protein-coupled receptors: BK receptor 1 (B1R) and BK receptor 2.
Ramadass, M, Kishore, U, Ji, Y, Pednekar, L, Peerschke, EIB, Ghebrehiwet, B, David, H, Galanakis, DK, Valentino, A, Kew, RR, Hosszu, KH   +10 more
core   +1 more source