Results 11 to 20 of about 58,368 (237)

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization [PDF]

Frontiers in Immunology, 2014
Complement is a critical system of enzymes, regulatory proteins, and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions including infectious disease and autoimmunity.
Bohlson, Suzanne S., O’Conner, Sean D., Hulsebus, Holly Jo, Ho, Minh-Minh, Fraser, Deborah A.   +4 more
openaire   +3 more sources

C1q A08 Is a Half-Cryptic Epitope of Anti-C1q A08 Antibodies in Lupus Nephritis and Important for the Activation of Complement Classical Pathway

Frontiers in Immunology, 2020
To investigate the fine epitope(s) of anti-C1q A08 antibodies and their roles in complement activation in lupus nephritis, C1q A08 and related peptides with various amino acid sequences around A08 were synthesized.
Wen-Jun Wu, Wen-Jun Wu, Wen-Jun Wu, Wen-Jun Wu, Wen-Jun Wu, Wen-Jun Wu, Ying Tan, Ying Tan, Ying Tan, Ying Tan, Xiao-Ling Liu, Xiao-Ling Liu, Xiao-Ling Liu, Xiao-Ling Liu, Feng Yu, Feng Yu, Feng Yu, Feng Yu, Feng Yu, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao   +23 more
doaj   +1 more source

CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes [PDF]

Iranian Journal of Immunology, 2019
Background: CD93 has originally been known as a C1q receptor, and many studies have demonstrated that CD93 is expressed on hematopoietic stem cells, B cell progenitors, myeloid and monocytic cells.
Shohreh Fakhari, Hamed Bashiri, Bayazid Ghaderi, Kaveh Tari, Ali Jalili   +4 more
doaj   +1 more source

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation [PDF]

, 2015
Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation.
Agostinis, C, Botto, M, Bulla, R, Durigutto, P, Guarnotta, C, Ling, GS, Rami, D, Tedesco, F, Tripodo, C, Zorzet, S   +9 more
core   +3 more sources

Peptide inhibitor of complement C1 (PIC1), a novel suppressor of classical pathway activation: mechanistic studies and clinical potential

Frontiers in Immunology, 2014
The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses as well as an essential homeostatic role in the clearance of damaged self-antigens.
Julia A Sharp, Pamela H. Whitley, Kenji M. Cunnion, Kenji M. Cunnion, Neel Kumar Krishna, Neel Kumar Krishna   +5 more
doaj   +1 more source

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Green, Malcolm L. H., Salvador-Morales, Carolina, Sim, Edith, Sim, Robert B., Sloan, Jeremy   +5 more
core   +2 more sources

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H., Mitchell, Daniel A., Schmid, Ralf, Schwaeble, Wilhelm J., Wallis, Russell   +4 more
core   +1 more source

Is it all that bad when living with an intracellular protozoan? The role of Trypanosoma cruzi calreticulin in angiogenesis and tumor growth

Frontiers in Oncology, 2015
The immune system protects against disease, but may aberrantly silence immunity against altered self, with consequent development of malignancies. Among the components of the endoplasmic reticulum (ER), important in immunity, is calreticulin (CRT) that ...
GALIA eRAMIREZ-TOLOZA, LORENA eAGUILAR-GUZMAN, CAROLINA eVALCK, PAULA eABELLO, LUIS ARTURO FERREIRA   +4 more
doaj   +1 more source

SLE: Novel Postulates for Therapeutic Options

Frontiers in Immunology, 2020
Genetic deficiency in C1q is a strong susceptibility factor for systemic lupus erythematosus (SLE). There are two major hypotheses that potentially explain the role of C1q in SLE.
Kinga K. Hosszu, Alisa Valentino, Ellinor I. Peerschke, Berhane Ghebrehiwet   +3 more
doaj   +1 more source