Results 31 to 40 of about 30,787 (208)

C1q as a target molecule to treat human disease: What do mouse studies teach us?

Frontiers in Immunology, 2022
The complement system is a field of growing interest for pharmacological intervention. Complement protein C1q, the pattern recognition molecule at the start of the classical pathway of the complement cascade, is a versatile molecule with additional non ...
Kristina Schulz, Kristina Schulz, Marten Trendelenburg, Marten Trendelenburg   +3 more
doaj   +1 more source

C1q, Autoimmunity and Apoptosis

Immunobiology, 2002
Deficiency of classical pathway complement components displays a hierarchical association with the development of systemic lupus erythematosus (SLE). Individuals with deficiency of C1q, the first component of the classical pathway of activation, have the highest prevalence of SLE and the most severe manifestations of the disease. However, complement is
Marina, Botto, Mark J, Walport
openaire   +2 more sources

Monocyte expressed macromolecular C1 and C1q receptors as molecular sensors of danger: Implications in SLE.

Frontiers in Immunology, 2014
The ability of circulating blood monocytes to express C1q receptors (cC1qR and gC1qR)synthesize and secrete the classical pathway proteins C1q, C1r and C1s and their regulator, C1-INH is very well established.
Berhane eGhebrehiwet, Kinga K Hosszu, Alisa M Valentino, Yan eJi, Ellinor I.B. Peerschke   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

C1q Levels: A Reliable Biomarker for Differentiating Active and Latent Tuberculosis Infection

International Journal of Mycobacteriology
Background: Tuberculosis (TB) poses a significant public health challenge, particularly because it can exist in an asymptomatic latent phase. Latent TB infection indicates the presence of Mycobacterium tuberculosis without clinical symptoms.
Sepideh Darougar, Afshin Moniri, Parvaneh Baghaei, Esmaeil Mortaz, Makan Sadr, Arad Moniri, Majid Marjani, Payam Tabarsi   +7 more
doaj   +1 more source

Mapping of the complement C1q binding site on Trichinella spiralis paramyosin

Parasites & Vectors, 2018
Background Trichinella spiralis is a tissue-dwelling parasite has developed the ability to evade the host immune attack to establish parasitism in a host.
Zixia Wang, Chunyue Hao, Jingjing Huang, Qinghui Zhuang, Bin Zhan, Xinping Zhu   +5 more
doaj   +1 more source

Epitope-Specific Anti-C1q Autoantibodies in Systemic Lupus Erythematosus

Frontiers in Immunology, 2022
ObjectiveIn patients with systemic lupus erythematosus (SLE) complement C1q is frequently targeted by autoantibodies (anti-C1q), that correlate best with active renal disease. Anti-C1q bind to largely unknown epitopes on the collagen-like region (CLR) of
Jessica S. Kleer, Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Gräfitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg, Marten Trendelenburg   +12 more
doaj   +1 more source

Rheumatologic Manifestations of Patients With Type B Insulin Resistance

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown   +4 more
wiley   +1 more source

Autoantibodies against complement component C1q in systemic lupus erythematosus

Clinical & Translational Immunology, 2021
Systemic lupus erythematosus (SLE) is the archetype of a systemic autoimmune disease, but the multifaceted pathogenic mechanisms leading to inflammation and organ damage are not fully understood.
Marten Trendelenburg
doaj   +1 more source

Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang, Laurence Magder, Daniel Goldman, Judith A. James, Joel M. Guthridge, Carla Guthridge, Peter Izmirly, Jill P. Buyon, H. Michael Belmont, Richard A. Furie, Noa Schwartz, Chaim Putterman, Jennifer L. Barnas, Jennifer H. Anolik, Sarah French, Maria Dall'Era, Avi Z. Rosenberg, Jeffrey Hodgin, Dawit S. Demeke, the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (RA/SLE) Network, Michelle Petri, Andrea Fava   +21 more
wiley   +1 more source