Results 21 to 30 of about 30,787 (208)
Interaction of C1q with the Receptor Calreticulin Requires a Conformational Change in C1q [PDF]
Scandinavian Journal of Immunology, 2004 Abstract The interaction between C1q and the chaperone calreticulin was studied under various conditions. When both proteins were present in equal amounts in solution, no interaction could be demonstrated. However, C1q immobilized on a hydrophobic surface, exposed to heat‐treatment or bound to immunoglobulins (Igs) showed a strong ...
A, Steinø +3 more
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Marine Drugs, 2019 C1q-domain-containing (C1qDC) proteins are rapidly emerging as key players in the innate immune response of bivalve mollusks. Growing experimental evidence suggests that these highly abundant secretory proteins are involved in the recognition of microbe ...
Marco Gerdol +2 more
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Frontiers in Immunology, 2016 The heterotrimeric globular head (gC1q) domain of human C1q is made up of the C-terminal ends of the three individual chains, ghA, ghB and ghC. The receptor for the gC1q domain is a multi-functional pattern recognition protein, gC1qR. Since understanding
Lina Pednekar +12 more
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Is the anti-tumor property of Trypanosoma cruzi infection mediated by its Calreticulin?
Frontiers in Immunology, 2016 Eight to 10 million people in 21 endemic countries are infected with Trypanosoma cruzi. However, only 30% of those infected develop symptoms of Chagas’ disease, a chronic, neglected tropical disease worldwide. Similar to other pathogens, T.
Galia Andrea Ramírez-Toloza +2 more
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Clinical significance of serum complement C1q in diagnosis of malignant tumors
陆军军医大学学报, 2023 Objective To investigate the serum level of complement C1q in patients with malignant tumors and its clinical significance in the diagnosis of the tumors. Methods A retrospective analysis was conducted on 468 patients with malignant tumors (including 164
WANG Yunlong, LI Hongsen, WU Lixiang
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Immunobiology, 2007 C1q binds to immune complexes to elicit complement-dependent microbial killing and enhance phagocytosis. Besides this classical role, C1q also opsonizes apoptotic cells for clearance by phagocytes. C1q deficiency increases susceptibility to microbial infections and is also associated with elevated autoimmunity as characterized by increased apoptotic ...
Lu, J., Wu, X., Teh, B.K.
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Transcriptional factor PU.1 regulates decidual C1q expression in early pregnancy in human
Frontiers in Immunology, 2015 C1q is the first recognition subcomponent of the complement classical pathway, which in addition to being synthesized in the liver, is also expressed by macrophages and dendritic cells.
Priyaa Madhukaran Raj +5 more
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Frontiers in Immunology, 2022 C1q, the recognition molecule of the classical pathway of the complement system, plays a central role in pregnancy. Lack of C1q is characterized by poor trophoblast invasion and pregnancy failure.
Chiara Agostinis +20 more
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The complement system at the embryo implantation site: friend or foe?
Frontiers in Immunology, 2012 An inflammatory-like process and vascular remodeling represent the main changes that occur in decidua in the early phase of pregnancy. These changes are partly induced by trophoblast cells that colonize the decidua and are also contributed by the ...
Roberta eBulla +2 more
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Anti-C1q autoantibodies, novel tests and clinical consequences
Frontiers in Immunology, 2013 Although anti-C1q autoantibodies have been described more than four decades ago a constant stream of papers describing clinical associations or functional consequences highlights that anti-C1q antibodies are still hot and happening.
Michael eMahler +2 more
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