Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States
Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1330-1348, August 2025.ABSTRACT Microglia, the resident immune‐competent cells of the brain, become dysfunctional in Alzheimer's disease (AD), and their aberrant immune responses contribute to the accumulation of pathological proteins and neuronal injury. Genetic studies implicate microglia in the development of AD, prompting interest in developing immunomodulatory therapies
Madison K. Kuhn, Elizabeth A. Proctor
wiley +1 more source
A unique property of a plasma proteoglycan, the C1q inhibitor. An anticoagulant state resulting from its binding to fibrinogen. [PDF]
, 1994 Dennis K. Galanakis, Berhane Ghebrehiwet
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Acta Physiologica, Volume 241, Issue 8, August 2025.ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth +2 more
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Isolation, molecular properties and allotype of mouse C1q.
, 1984 Jin Seino +3 more
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Human serum amyloid P component oligomers bind and activate the classical complement pathway via residues 14-26 and 76-92 of the A chain collagen-like region of C1q. [PDF]
, 1993 S C Ying +3 more
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British Journal of Pharmacology, Volume 182, Issue 16, Page 3800-3817, August 2025.Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti +10 more
wiley +1 more source
Inhibitors of C1q biosynthesis suppress activation of murine macrophages for both antibody-independent and antibody-dependent tumor cytotoxicity. [PDF]
, 1990 Richard W. Leu +3 more
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TREM2‐Mediated Myeloid Cells Protect Against Pathological Choroidal Neovascularization
The FASEB Journal, Volume 39, Issue 14, 31 July 2025.This study demonstrates that TREM2 is selectively upregulated in activated microglia and macrophages during choroidal neovascularization (CNV). Single‐cell RNA sequencing and immunostaining confirmed its enrichment in IBA1+ myeloid cells near CNV lesions. Functionally, TREM2 haploinsufficiency worsened CNV lesion size and vascular leakage.
Tianxi Wang +5 more
wiley +1 more source
Anti-C1q antibodies in patients with systemic lupus erythematosus treated by rituximab
Терапевтический архив, 2013 AIM: To determine the time course of changes in the blood levels of antibodies (Ab) to complement component C1q (a-C1q) in patients with systemic lupus erythematosus (SLE) during rituximab (RTM) therapy and the association with organ injuries in SLE ...
M É Tsanian +4 more
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