Results 71 to 80 of about 68,566 (325)

Rusty microglia: trainers of innate immunity in Alzheimer's disease [PDF]

, 2018
Alzheimer's disease, the most common form of dementia, is marked by progressive cognitive and functional impairment believed to reflect synaptic and neuronal loss.
Adonis Sfera, Adonis Sfera, Amy I. Price, Carolina Osorio, Eddie Diaz, Michael Cummings, Roberto Gradini   +6 more
core   +2 more sources

Mapping of the complement C1q binding site on Trichinella spiralis paramyosin

Parasites & Vectors, 2018
Background Trichinella spiralis is a tissue-dwelling parasite has developed the ability to evade the host immune attack to establish parasitism in a host.
Zixia Wang, Chunyue Hao, Jingjing Huang, Qinghui Zhuang, Bin Zhan, Xinping Zhu   +5 more
doaj   +1 more source

Epitope-Specific Anti-C1q Autoantibodies in Systemic Lupus Erythematosus

Frontiers in Immunology, 2022
ObjectiveIn patients with systemic lupus erythematosus (SLE) complement C1q is frequently targeted by autoantibodies (anti-C1q), that correlate best with active renal disease. Anti-C1q bind to largely unknown epitopes on the collagen-like region (CLR) of
Jessica S. Kleer, Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Gräfitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg, Marten Trendelenburg   +12 more
doaj   +1 more source

Trichinella spiralis Calreticulin S-Domain Binds to Human Complement C1q to Interfere With C1q-Mediated Immune Functions

Frontiers in Immunology, 2020
Helminths develop strategies to escape host immune responses that facilitate their survival in the hostile host immune environment. Trichinella spiralis, a tissue-dwelling nematode, has developed a sophisticated strategy to escape complement attack.
Shuai Shao, Chunyue Hao, B. Zhan, Q. Zhuang, Limei Zhao, Yi Chen, Jingjing Huang, Xinping Zhu   +7 more
semanticscholar   +1 more source

Complement C1q Enhances Primary Hemostasis [PDF]

Frontiers in Immunology, 2020
The cross-talk between the inflammatory complement system and hemostasis is becoming increasingly recognized. The interaction between complement C1q, initiation molecule of the classical pathway, and von Willebrand factor (vWF), initiator molecule of primary hemostasis, has been shown to induce platelet rolling and adhesion in vitro.
Marten Trendelenburg, Marten Trendelenburg, Claudia Donat, Dimitrios A. Tsakiris, Robert Kölm, Eylul Tuncer, Kinga Csorba   +6 more
openaire   +3 more sources

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Anthony H. Keeble, Brodsky-Doyle, Chen, Chen, Christopher Furze, Daniel A. Mitchell, Doliana, Emsley, Fan, Feinberg, Girija, Haurum, Heise, Hohenester, Hoppe, Jensenius, Julia Toth, Kaufman, Kurata, Phillips, Porter, Reid, Reid, Reid, Russell Wallis, Scherer, Shoulders, Sim, Strang, Teillet, Uemura, Umakhanth Venkatraman Girija, Wallis, Wallis, Wallis, Wallis, Wallis, Wallis, Wilhelm J. Schwaeble   +38 more
core   +2 more sources

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Emerging and novel functions of complement protein C1q

Frontiers in Immunology, 2015
Complement protein C1q, the recognition subcomponent of the classical pathway, performs a diverse range of complement and non-complement functions. It can bind various ligands derived from self, non-self and altered-self and modulate the functions of ...
Lubna eKouser, Shanmuga Priyaa Madhukaran, Abhishek eShastri, Anuvinder eSaraon, Janez eFerluga, Maha eAl-Mozaini, Uday eKishore   +6 more
doaj   +1 more source

Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation. [PDF]

, 1993
Although very similar in sequence, the four subclasses of human immunoglobulin G (IgG) differ markedly in their ability to activate complement. Glu318-Lys320-Lys322 has been identified as a key binding motif for the first component of complement, C1q ...
Morrison, SL, Smith, RI, Tao, MH
core  

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core   +1 more source