Results 71 to 80 of about 57,775 (215)

Emerging and novel functions of complement protein C1q

Frontiers in Immunology, 2015
Complement protein C1q, the recognition subcomponent of the classical pathway, performs a diverse range of complement and non-complement functions. It can bind various ligands derived from self, non-self and altered-self and modulate the functions of ...
Lubna eKouser, Shanmuga Priyaa Madhukaran, Abhishek eShastri, Anuvinder eSaraon, Janez eFerluga, Maha eAl-Mozaini, Uday eKishore   +6 more
doaj   +1 more source

Complement protein C1q stimulates hyaluronic acid degradation via gC1qR/HABP1/p32 in malignant pleural mesothelioma

Frontiers in Immunology, 2023
Complement component C1q can act as a pro-tumorigenic factor in the tumor microenvironment (TME). The TME in malignant pleural mesothelioma (MPM) is rich in C1q and hyaluronic acid (HA), whose interaction enhances adhesion, migration and proliferation of
Andrea Balduit, Romana Vidergar, Paola Zacchi, Alessandro Mangogna, Chiara Agostinis, Micaela Grandolfo, Cristina Bottin, Francesco Salton, Paola Confalonieri, Andrea Rocca, Fabrizio Zanconati, Fabrizio Zanconati, Marco Confalonieri, Uday Kishore, Berhane Ghebrehiwet, Roberta Bulla   +15 more
doaj   +1 more source

Annus Mirabilis - a guide to the 6th European Lupus meeting 3-5 March 2005 [PDF]

, 2005
This article has no ...
Bowman, S.J., Giles, I.P., Ioannou, Y., Isenburg, D.A., Rahman, A.   +4 more
core  

Complement protein C1q interacts with DC-SIGN via its globular domain, and thus may interfere with HIV-1 transmission [PDF]

, 2016
Dendritic Cells (DCs) are the most potent antigen presenting cells capable of priming naïve T cells. Its C-type lectin receptor, DC-SIGN, regulates a wide range of immune functions.
Appelmelk, Balzarini, Balzarini, Banapour, Banki, Bashirova, Bouhlal, Bouhlal, Boyer, Burton, Caffrey, Caparros, Curtis, Delibrias, Delibrias, den Dunnen, Ebenbichler, Fausther-Bovendo, Gaboriaud, Gadjeva, Gadjeva, Geijtenbeek, Geijtenbeek, Geijtenbeek, Geijtenbeek, Ghebrehiwet, Ghebrehiwet, Gras, Gringhuis, Hoorelbeke, Hosszu, Kang, Kang, Kishore, Kittlesen, Kojouharova, Lang, Leavy, Lozach, Maeda, Manches, Marschang, Martinez, Matthews, McLachlan, Mitchell, Mohan, Nayak, Nayak, Pednekar, Pinter, Pohlmann, Prabagar, Roumenina, Sarkar, Solder, Szabo, Tacnet-Delorme, Thielens, Thielens, Vegh, Wang   +61 more
core   +1 more source

Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression

Scientific Reports, 2017
C1q collagen-like region (CLR) engaging and activating the LAIR-1 inhibitory immunoreceptor represents a non-complement mechanism for maintaining immune quiescence.
Myoungsun Son, Betty Diamond, Bruce T. Volpe, Cynthia B. Aranow, Meggan C. Mackay, Frances Santiago-Schwarz   +5 more
doaj   +1 more source

Clinical impact of complement (C1q, C3d) binding De Novo donor-specific HLA antibody in kidney transplant recipients. [PDF]

PLoS ONE, 2018
INTRODUCTION:Complement binding activity of donor-specific HLA antibodies (DSA) has been suggested as a new tool to stratify immunologic risk in kidney transplantation (KT).
Hyeyoung Lee, Eunhee Han, Ae-Ran Choi, Tae Hyun Ban, Byung Ha Chung, Chul Woo Yang, Yeong Jin Choi, Eun-Jee Oh   +7 more
doaj   +1 more source

Glomerular deposition of C1q and anti-C1q antibodies in mice following injection of antimouse C1q antibodies

Clinical and Experimental Immunology, 2003
SUMMARY Anti-C1q autoantibodies are present in the serum of patients with different autoimmune diseases such as systemic lupus erythematosus (SLE). The occurrence of these autoantibodies correlates with renal involvement. In the present study we examined whether injection of rabbit antimouse C1q antibodies in mice leads to deposition in ...
L A, Trouw, M A, Seelen, J M G J, Duijs, H, Benediktsson, C, Van Kooten, M R, Daha   +5 more
openaire   +3 more sources

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

C1q, Autoimmunity and Apoptosis

Immunobiology, 2002
Deficiency of classical pathway complement components displays a hierarchical association with the development of systemic lupus erythematosus (SLE). Individuals with deficiency of C1q, the first component of the classical pathway of activation, have the highest prevalence of SLE and the most severe manifestations of the disease. However, complement is
Marina, Botto, Mark J, Walport
openaire   +2 more sources

An Open‐Label Phase 1b Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ANX005 in Patients with Huntington's Disease

Movement Disorders, EarlyView.
Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar, Pinky Agarwal, Karen Anderson, Daniel Claassen, Marissa Dean, Andrew Duker, Burton Scott, Benjamin Hoehn, Ann Mongan, Ping Lin, Ellen Cahir‐McFarland, Lori Taylor, Glenn Morrison, Ted Yednock, Sanjay Keswani, Henk‐Andre Kroon   +15 more
wiley   +1 more source