Degradation of collagen I by activated C1s in periodontal Ehlers-Danlos Syndrome [PDF]
Frontiers in Immunology, 2023 Periodontal Ehlers-Danlos syndrome (pEDS) is an autosomal dominant disorder characterized by early-onset periodontitis leading to premature loss of teeth, lack of attached gingiva and thin and fragile gums leading to gingival recession. Connective tissue
Albert Amberger +8 more
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Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs [PDF]
Frontiers in Immunology, 2022 The most commonly used markers to assess complement activation are split products that are produced through activation of all three pathways and are located downstream of C3. In contrast, C4d derives from the cleavage of C4 and indicates either classical
Lisa Hurler +156 more
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Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement functionResearch in context [PDF]
EBioMedicineSummary: Background: Antibody drugs blocking the complement classical pathway (CP) often require frequent intravenous administration to overcome the high abundance or rapid turnover of complement proteins.
Adrian W.S. Ho +27 more
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The Role of Exchange Energy in Modeling Core-Electron Binding Energies of Strongly Polar Bonds [PDF]
MoleculesAccurate determination of carbon core-electron binding energies (C1s CEBEs) is crucial for X-ray photoelectron spectroscopy (XPS) assignments and predictive computational modeling.
Feng Wang, Delano P. Chong
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The role of the Lys628 (192) residue of the complement protease, C1s, in interacting with peptide and protein substrates [PDF]
Frontiers in Immunology, 2014 The C1s protease of the classical complement pathway propagates the initial activation of this pathway of the system by cleaving and thereby activating the C4 and C2 complement components.
Lakshmi Carmel Wijeyewickrema +2 more
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Computational Investigation of Smooth Muscle Cell Plasticity in Atherosclerosis and Vascular Calcification: Insights from Differential Gene Expression Analysis of Microarray Data [PDF]
BioengineeringThe dedifferentiation of smooth muscle cells (SMCs) is the main cause of atherosclerosis and vascular calcification. This study integrated the gene expression data of multiple microarrays to identify relevant marker molecules.
Daniel Liu, Jimmy Kuo, Chorng-Horng Lin
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Comment on "Could signal peptide complement C1r/C1s, Uegf, and Bmp1, and epidermal growth factor-containing protein 1 be a therapeutic target in the pathogenesis of preeclampsia?" [PDF]
Rev Assoc Med Bras (1992)Cheng C, Wang Y.
europepmc +2 more sources
Quantitative fluorescence resonance energy transfer-based immunoassay for activated complement C1s
Frontiers in Immunology, 2023 ObjectivesC1s activation is associated with the pathogenesis of various diseases, indicating the potential value of C1s activation detection in clinic.
Jun Ye +5 more
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Complement C1s as a diagnostic marker and therapeutic target: Progress and propective
Frontiers in Immunology, 2022 The molecules of the complement system connect the effectors of innate and adaptive immunity and play critical roles in maintaining homeostasis. Among them, the C1 complex, composed of C1q, C1r, and C1s (C1qr2s2), is the initiator of the classical ...
Jun Ye +4 more
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HMGB1 cleavage by complement C1s and its potent anti-inflammatory product
Frontiers in Immunology, 2023 Complement C1s association with the pathogenesis of several diseases cannot be simply explained only by considering its main role in activating the classical complement pathway.
Marie Lorvellec +11 more
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