Results 11 to 20 of about 52,049 (318)

Identification of Diagnostic Biomarkers and Their Correlation with Immune Infiltration in Age-Related Macular Degeneration

open access: yesDiagnostics, 2021
Age-related macular degeneration (AMD) is a progressive neurodegenerative disease of the central retina, with no suitable biomarkers for early diagnosis and treatment.
Yuyang Zeng   +3 more
doaj   +1 more source

Gene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vaccine immunogens.

open access: yesPLoS ONE, 2020
Several candidate HIV subunit vaccines based on recombinant envelope (Env) glycoproteins have been advanced into human clinical trials. To facilitate biopharmaceutical production, it is necessary to produce these in CHO (Chinese Hamster Ovary) cells, the
Sophia W Li   +7 more
doaj   +1 more source

Construction of a competitive endogenous RNA network and analysis of potential regulatory axis targets in glioblastoma

open access: yesCancer Cell International, 2021
Background Glioblastoma is the most common primary malignant brain tumor. Because of the limited understanding of its pathogenesis, the prognosis of glioblastoma remains poor. This study was conducted to explore potential competing endogenous RNA (ceRNA)
Kai Yu   +11 more
doaj   +1 more source

Niemann-Pick C1 [PDF]

open access: yesCurrent Biology, 2002
What is it? Niemann-Pick C1 (NPC1) is a 1278 amino acid membrane protein residing in the endosomal–lysosomal system. Studies in humans and animal models substantiate NPC1 as a crucial player in intracellular cholesterol trafficking.Can we live without it?
Liscum, Laura, Wojtanik, Kari
openaire   +2 more sources

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

open access: yes, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H.   +4 more
core   +1 more source

C1-inhibitor/C1-inhibitor antibody complexes in acquired angioedema due to C1-inhibitor deficiency

open access: yesOrphanet Journal of Rare Diseases, 2023
Abstract Background Autoantibodies against C1-inhibitor (C1-INH-Ab) have a diagnostic value in acquired angioedema due to C1-inhibitor deficiency (C1-INH-AAE), even though antibodies can circulate in complexes, which can be undetectable by proven methods.
Zsofia Polai   +6 more
openaire   +3 more sources

Sample-path large deviations for tandem and priority queues with Gaussian inputs [PDF]

open access: yes, 2005
This paper considers Gaussian flows multiplexed in a queueing network. A single node being a useful but often incomplete setting, we examine more advanced models. We focus on a (two-node) tandem queue, fed by a large number of Gaussian inputs.
Mandjes, Michel, van Uitert, Miranda
core   +7 more sources

Electronic states of trans-polyacetylene, poly(p-phenylene vinylene) and sp-hybridised carbon species in amorphous hydrogenated carbon probed by resonant Raman scattering [PDF]

open access: yes, 2009
Inclusions of sp-hybridised, trans-polyacetylene [trans-(CH)x] and poly(p-phenylene vinylene) (PPV) chains are revealed using resonant Raman scattering (RRS) investigation of amorphous hydrogenated carbon (a-C:H) films in the near IR - UV range.
Bell, J. M., Rybachuk, M.
core   +2 more sources

The axis of complement C1 and nucleolus in antinuclear autoimmunity

open access: yesFrontiers in Immunology, 2023
Antinuclear autoantibodies (ANA) are heterogeneous self-reactive antibodies that target the chromatin network, the speckled, the nucleoli, and other nuclear regions.
Shan Wu   +15 more
doaj   +1 more source

Understanding Charge Transfer in Donor-Acceptor/Metal Systems: A Combined Theoretical and Experimental Study [PDF]

open access: yes, 2013
We develop an effective potential approach for assessing the flow of charge within a two-dimensional donor-acceptor/metal network based on core-level shifts.
Cabellos, J. L.   +8 more
core   +2 more sources

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