Results 81 to 90 of about 4,044,136 (204)

Regulation of PKCα Activity by C1-C2 Domain Interactions [PDF]

Journal of Biological Chemistry, 2002
In this study, the role of interdomain interactions involving the C1 and C2 domains in the mechanism of activation of PKC was investigated. Using an in vitro assay containing only purified recombinant proteins and the phorbol ester, 4 beta-12-O-tetradecanoylphorbol-13-acetate (TPA), but lacking lipids, it was found that PKC alpha bound specifically ...
Simon J, Slater, Jodie L, Seiz, Anthony C, Cook, Christopher J, Buzas, Steve A, Malinowski, Jennifer L, Kershner, Brigid A, Stagliano, Christopher D, Stubbs   +7 more
openaire   +2 more sources

Phosphorylation modification reverses the transcriptional inhibitory activity of CsMYB4a in tea plants (Camellia sinensis)

Horticultural Plant Journal
The members of the fourth subgroup of R2R3-MYB (Sg4 members) are well-known inhibitors of phenylpropanoid and lignin synthesis pathways. The C2 domain is closely related to the transcriptional inhibitory activity of Sg4 members.
Guoliang Ma, Yunyun Han, Tongtong Li, Tao Xia, Liping Gao   +4 more
doaj   +1 more source

Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. [PDF]

, 2000
We report here that guanylyl cyclase activity is associated with two large integral membrane proteins (PfGCalpha and PfGCbeta) in the human malaria parasite Plasmodium falciparum.
Altschul, Bakalyar, Baker, Bilker, Brooks, Bzik, Cavalier-Smith, Chinkers, Cowman, Defer, Devereaux, Don, Garbers, Gilman, Harte, Ishikawa, Janssens, Jencks, Kawamoto, Koch, Krupinsky, Li, Li, Li, Linder, Liu, MacLennan, Nakane, Pitt, Ripmaster, Robson, Sambrook, Sanchez, Saul, Schulkes, Schultz, Schultz, Sunahara, Sunahara, Tang, Taylor, Tesmer, Thaithong, Toyofuku, Triglia, Triglia, Triglia, Tucker, van Es, Walliker, Ward, Zhang, Zimmerman   +52 more
core   +1 more source

Characterization and Solution Structure of the Factor VIII C2 Domain in a Ternary Complex with Classical and Non-classical Inhibitor Antibodies*

Journal of Biological Chemistry, 2013
Background: The development of antibodies against coagulation factor VIII (fVIII) is a serious complication of hemophilia A. Results: Small angle x-ray scattering reveals a molecular envelope solution structure of two inhibitor antibodies bound to the C2
J. D. Walter, R. Werther, M. Polozova, J. Pohlman, J. Healey, Shannon L. Meeks, P. Lollar, P. Spiegel   +7 more
semanticscholar   +1 more source

Interdisciplinary Studies of the Multifaceted C2 Domains

The FASEB Journal, 2010
The C2 domain (~130 residues) was originally identified as one of two conserved regulatory domains of Ca2+‐dependent protein kinases C. A large number of proteins containing the C2 domain have been identified since, and most of them are involved in signal transduction or membrane trafficking.
Robert V Stahelin, Hui Yu, Deborah Olmstead, Christopher Gunasekaran   +3 more
openaire   +1 more source

Peak Effect in Superconductors: Absence of Phase Transition and Possibility of Jamming in Vortex Matter

, 2006
The magnetic field $B$ dependence of the critical current $I_c$ for the vortex phase of a disordered superconductor is studied numerically at zero temperature.
Andrei E. Y., Banerjee S. S., Chandran M., Chandran M., Crabtree G. W., Fasano Y., Giamarchi T., Higgins M. J., Isino M., Knight J. B., Ling X., MAHESH CHANDRAN, Olson C. J., Ravikumar G., Roy S. B., Ryu S., Sambandamurthy G., Schleser R., Tamegai T., Tinkham M., Wördenweber R.   +20 more
core   +1 more source

P22 c2 repressor. Domain structure and function.

Journal of Biological Chemistry, 1983
The c2 repressor of bacteriophage P22 can be digested with trypsin, chymotrypsin, or elastase to yield stable fragments. Purified NH2-terminal fragments, like intact repressor, bind specifically to P22 operator DNA and also mediate positive and negative control of transcription.
J, De Anda, A R, Poteete, R T, Sauer
openaire   +2 more sources

Partial regularity results for minimizers of quasiconvex functionals of higher order [PDF]

, 2002
We consider minimizers u ∈Wm,p(,RN) of uniformly strictly quasiconvex functionals F(u) = ∫ f (Dmu)dLn of higher order. Here is a domain inRn, m 1, and f is a C2-integrand with growth of order p, p 2.
Kronz, Manfred
core   +1 more source

RAB-10 Promotes EHBP-1 Bridging of Filamentous Actin and Tubular Recycling Endosomes.

PLoS Genetics, 2016
EHBP-1 (Ehbp1) is a conserved regulator of endocytic recycling, acting as an effector of small GTPases including RAB-10 (Rab10). Here we present evidence that EHBP-1 associates with tubular endosomal phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2 ...
Peixiang Wang, Hang Liu, Yu Wang, Ou Liu, Jing Zhang, Adenrele Gleason, Zhenrong Yang, Hui Wang, Anbing Shi, Barth D Grant   +9 more
doaj   +1 more source

Schistosoma mansoni TOR is a tetraspanning orphan receptor on the parasite surface [PDF]

, 2017
A trispanning orphan receptor (TOR) has been described in Schistosoma haematobium and S. mansoni. Here we report the complete molecular organization of the S. mansoni TOR gene, also known as SmCRIT (complement C2 receptor inhibitor trispanning).
LOCHMATTER, C., MARTIN, P. J., SCHIFFERLI, J. A.   +2 more
core