Results 231 to 240 of about 38,034 (262)

Patterning the differentiation of C2C12 skeletal myoblasts

Integrative Biology, 2011
Mammalian cells are sensitive to the physical properties of their micro-environment such as the stiffness and geometry of the substrate. It is known that the stiffness of the substrate plays a key role in the process of mammalian myogenesis. However, the effect of geometrical constraints on the process of myogenic differentiation needs to be explored ...
Piyush, Bajaj, Bobby, Reddy, Larry, Millet, Chunan, Wei, Pinar, Zorlutuna, Gang, Bao, Rashid, Bashir   +6 more
openaire   +2 more sources

Graphene‐Based Patterning and Differentiation of C2C12 Myoblasts

Advanced Healthcare Materials, 2013
This study aims at generating highly aligned functional myotubes using graphene as the underlying scaffold. Graphene not only supports the growth of C2C12 muscle cells but also enhances its differentiation and leads to spontaneous patterning of myotubes.
Bajaj, Piyush, Rivera, Jose A, Marchwiany, Daniel, Solovyeva, Vita, Bashir, Rashid   +4 more
openaire   +2 more sources

A role for PKCε during C2C12 myogenic differentiation

Cellular Signalling, 2010
In a previous report we have demonstrated that PLCgamma1 is involved in the differentiation process of C2C12 myoblasts, induced by insulin administration. In order to identify the downstream targets of PLCgamma1-dependent signalling, we have analyzed the expression of DAG-dependent PKC isoforms during muscle differentiation. We show that during myotube
GABOARDI, GIAN CARLO, RAMAZZOTTI, GIULIA, Bavelloni A, PIAZZI, MANUELA, FIUME, ROBERTA, BILLI, ANNA MARIA, Matteucci A, FAENZA, IRENE, COCCO, LUCIO ILDEBRANDO   +8 more
openaire   +3 more sources

CXXC5 regulates differentiation of C2C12 myoblasts into myocytes

Journal of Muscle Research and Cell Motility, 2014
CXXC5 is a member of the CXXC-type zinc-finger domain containing protein family, which is suggested to function in gene transcription, cell adhesion and cytoskeleton organization. Previous studies have revealed that CXXC5 is expressed in skeletal muscle, but whether it regulates skeletal myogenesis is yet unknown.
Guangming, Li, Xiangli, Ye, Xiyang, Peng, Yun, Deng, Wuzhou, Yuan, Yongqing, Li, Xiaoyang, Mo, Xijun, Wang, Yongqi, Wan, Xianchu, Liu, Tingfang, Chen, Zhigang, Jiang, Xiongwei, Fan, Xiushan, Wu, Yuequn, Wang   +14 more
openaire   +2 more sources

Attenuation of autophagic-proteolysis in C2C12 cells by saccharopine

Molecular and Cellular Biochemistry, 2015
Muscle wasting impairs physical function and leads people to a bedridden state. We previously demonstrated that lysine (Lys) suppresses autophagic-proteolysis through the Akt pathway. However, the effect of metabolites of Lys on proteolysis is unclear. In this study, we investigated the effect of saccharopine (Sac), a metabolite of Lys, on proteolysis ...
Tomonori, Sato, Yoshiaki, Ito, Takashi, Nagasawa   +2 more
openaire   +2 more sources

Ubc9 expression is essential for myotube formation in C2C12

Experimental Cell Research, 2006
Myogenic differentiation is a fundamental biological process that involves a hierarchical series of events that ultimately leads to muscle-specific gene expression and myofiber formation. Posttranslational modifications of the myogenic regulatory factors have been implicated as important regulatory mechanisms in this process.
Cecilia, Riquelme, Kristen K B, Barthel, Xiao-Feng, Qin, Xuedong, Liu   +3 more
openaire   +3 more sources

A siRNA Mediated Screen During C2C12 Myogenesis

2018
Myogenesis is a multistep process taking place during pre- and postnatal stages for muscle formation, growth, and regeneration. It is a highly regulated process involving many molecular factors which act during myoblast proliferation and differentiation.
Parenté, Alexis, Périé, Luce, Magnol, Laetitia, Bouhouche, Khaled, Blanquet, Véronique   +4 more
openaire   +4 more sources

Involvement of natriuretic peptide system in C2C12 myocytes

Molecular and Cellular Biochemistry, 2018
The natriuretic peptide system, a key regulator of cGMP signaling, comprises three types of natriuretic peptides, osteocrin/musclin (OSTN), and their natriuretic peptide receptors. Although this system plays important roles in many organs, its physiological roles in skeletal muscle have not been clearly described.
Kiyoshi Ishikawa, Taiki Hara, Kana Kato, Takeshi Shimomura, Kenji Omori   +4 more
openaire   +2 more sources

Pb inhibited C2C12 myoblast differentiation by regulating HDAC2

Toxicology, 2023
Myogenesis is a crucial process governing skeletal muscle development and homeostasis. Lead (Pb) exposure impaired the development and the health of bones, which slows the growth of children. However, it is far from clear what exactly the effects of Pb on skeletal muscle development are. In this study, C2C12 cells are commonly used as an in vitro model
Xiaozhen, Gu, Nan, Shen, Chengqing, Huang, Hui-Li, Wang   +3 more
openaire   +2 more sources

Role of PPARα in inflammatory response of C2C12 myotubes

Biochemical and Biophysical Research Communications
Recent studies have shown a role of inflammation in muscle atrophy and sarcopenia. However, no anti-inflammatory pharmacotherapy has been established for the treatment of sarcopenia. Here, we investigate the potential role of PPARα and its ligands on inflammatory response and PGC-1α gene expression in LPS-treated C2C12 myotubes.
Yuki Shimizu, Keiko Hamada, Tingting Guo, Chie Hasegawa, Yusuke Kuga, Katsushi Takeda, Takashi Yagi, Hiroyuki Koyama, Hiroshi Takagi, Daisuke Aotani, Hiromi Kataoka, Tomohiro Tanaka   +11 more
openaire   +2 more sources