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A young woman with membranoproliferative glomerulonephritis and persistent hypocomplementemia: a case report. [PDF]
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Membranoproliferative Glomerulonephritis und C3‑Glomerulopathie
Der Internist, 2019Based on an increasingly better pathophysiological understanding over the last 10 years, in 2010 a new classification of glomerulonephritis with dominant or codominant C3 deposits was introduced and the predominant subgoup was termed C3 glomerulopathy (C3G). In the current classification, immune complex mediated membranoproliferative glomerulonephritis
B, Hohenstein, K, Amann, J, Menne
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Eculizumab in post-transplant C3 glomerulonephritis caused by a C3 mutation
Clinical Nephrology, 2020C3 glomerulonephritis (C3GN) is a disorder of excess alternative complement activation leading to glomerular injury. Following kidney transplantation, C3GN has a high recurrence rate, and the overall prognosis is poor without treatment. However, treatment efficacy is highly variable.
Joon S, Kim +2 more
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Alternate C3 pathway activation in pneumococcal glomerulonephritis
The American Journal of Medicine, 1975Glomerulonephritis following pneumococcal infection has been observed, but possible immunopathologic mechanisms have not been adequately explored. Multiple serologic studies as well as light, immunofluorescence and electron microscopic evaluation of kidney biopsy tissue from a 4 year old girl with pneumococcal glomerulonephritis were performed ...
L R, Hyman +4 more
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C3 glomerulonephritis with a severe crescentic phenotype
Pediatric Nephrology, 2017C3 glomerulopathy (C3G) is rare type of glomerulonephritis resulting from the glomerular deposition of C3 due to dysregulation of the alternative pathway of complement. It is further subdivided into C3 glomerulonephritis (C3GN) and dense deposit disease (DDD), depending on the ultrastructural features. C3GN usually presents with a membranoproliferative
Aishwarya Ravindran +3 more
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C3 nephritic factor and mesangiocapillary glomerulonephritis
Pediatric Nephrology, 1997The association of a C3 splitting activity, known as C3 nephritic factor (C3NeF), with mesangiocapillary glomerulonephritis (MCGN), especially MCGN type II, has long been known. Several forms of C3NeF are now recognised, the main one being an IgG which acts as an autoantibody binding to factor H, a normally occurring component of the complement system.
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[Mesangial C3-glomerulonephritis].
Vutreshni bolesti, 199112 patients with mesangial C3-glomerulonephritis, 7 women and 5 men, aged 16-42, mean age 29.7 years, were followed up for 1-18 years, mean time 5.7 years. The disease was manifested most often by macroscopic hematuria or low degree proteinuria. Single patients had arterial hypertension. In only one patient there was a nephrotic syndrome.
V, Dimitrova, V, Minkova, N, Belovezhdov
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Membranoproliferative Glomerulonephritis and C3 Glomerulopathy
2013Membranoproliferative glomerulonephritis (MPGN) refers to a pattern of injury characterized by diffuse mesangial expansion due to mesangial and endocapillary proliferation and increased mesangial matrix, and thickened capillary walls, often with a double contour “tram-track” appearance [1, 2]. This pattern may be seen with immune complex deposition, or
Agnes B. Fogo +4 more
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C3 Glomerulopathy Masquerading as Acute Postinfectious Glomerulonephritis
American Journal of Kidney Diseases, 2012We report the case of a 63-year-old man who presented with acute kidney injury, active urine sediment, nephrotic syndrome, and hypocomplementemia after a recent report of a sore throat. Kidney biopsy showed diffuse proliferative and exudative glomerulonephritis with C3-dominant staining by immunofluorescence.
Gagangeet, Sandhu +5 more
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Membranoproliferative Glomerulonephritis and C3 Glomerulopathy
2014The terms membranoproliferative glomerulonephritis (MPGN) and mesangiocapillary glomerulonephritis (MCGN) are interchangeable and refer to the light microscopic appearances of cellular proliferation in the mesangial regions of the glomeruli, with expansion of both cells and mesangial matrix, accompanied by thickening of the glomerular capillary walls ...
Daniel Gale, Mared Owen-Casey
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