Results 131 to 140 of about 3,979 (154)

Microglia in Alzheimer's Disease: From Homeostatic Guardians to Multifaceted Drivers of Neuropathology. [PDF]

Cells
Ma L, Zhao Y, Cai C, Liu Q, Hu X, Wang L.   +5 more
europepmc   +1 more source

Complement in brain and eye disease: shared mechanisms, convergent pathologies, and common therapeutic opportunities. [PDF]

Mamm Genome
Nimmo J, Bright M, Yang Z, Nicholls LE, Morgan BP, Daskoulidou N, Daskoulidou N, Zelek WM.   +7 more
europepmc   +1 more source

LPS-Induced Intracellular Complement 3 Activation Regulated ATP Production in Yak Rumen Epithelial Cells. [PDF]

Vet Sci
Han Q, Zhang Q, Wu D, Yang Z, Huang J, Wang Z, Zou H, Peng Q, Meng Y, Jiang Y, Xiao J, Hu R.   +11 more
europepmc   +1 more source

PF4 at the Crossroads of Immunity and Neurodegeneration: A New Window Into Brain Aging. [PDF]

CNS Neurosci Ther
Xie Z.
europepmc   +1 more source

Targeting innate immunity to modulate bone metabolism: a novel strategy for osteoporosis treatment. [PDF]

Front Aging
Kou W, Lu X, Zhang Z, Liu K, Liu Z, Jiang B, Wang H, Li J, Lu H, Guo C, Cao L, Zhang X.   +11 more
europepmc   +1 more source

The complement system contributes to the immunosuppressive microenvironment of uveal melanoma. [PDF]

J Transl Med
Zherka I, Kalirai H, Majorova D, Coupland SE, Olcina MM.   +4 more
europepmc   +1 more source

A Novel Class of Complement 3a Receptor Agonists and Antagonists Derived from the TLQP-21 Peptide. [PDF]

J Med Chem
Rodriguez P, Pallais JP, He R, Razzoli M, McKee JL, Bock HA, McCorvy JD, Sham YY, DiMarchi R, Bartolomucci A.   +9 more
europepmc   +1 more source

The C3a/C3aR axis mediates anti-inflammatory activity and protects against uropathogenic E coli–induced kidney injury in mice

Kidney International, 2019
Both the C3a/C3aR and C5a/C5aR1 axes are regarded as important pathways for inducing and regulating inflammatory responses. It is well documented that the C5a/C5aR1 axis is a potent inflammatory mediator in the pathogenesis of many clinic disorders ...
Ting Zhang, Ke Li, Wuding Zhou
exaly   +2 more sources

Complement C3a Receptor (C3aR) Mediates Vascular Dysfunction, Hippocampal Pathology, and Cognitive Impairment in a Mouse Model of VCID

Translational Stroke Research, 2022
Vascular contributions to cognitive impairment and dementia (VCID) secondary to chronic mild-moderate cerebral ischemia underlie a significant percentage of cases of dementia.
Andrew F Ducruet, Saif Ahmad, Elliott J Mufson   +2 more
exaly   +2 more sources

Complement Activation and Up-Regulated Expression of Anaphylatoxin C3a/C3aR in Glioblastoma: Deciphering the Links with TGF-β and VEGF

Cancers, 2023
International audienceThe complement (C) innate immune system has been shown to be activated in the tumor microenvironment of various cancers. The C may support tumor growth by modulating the immune response and promoting angiogenesis through the actions
Mohamed Khettab, Franck Ah-Pine, Philippe Gasque   +2 more
exaly   +2 more sources