Results 161 to 170 of about 37,904 (214)
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Action of the C3b-Inactivator on Cell-Bound C3b
The Journal of Immunology, 1979Abstract The action of C3bINA and β1H on cell-bound C3b is described in this paper. The α-polypeptide of C3b that binds covalently to cell surfaces is cleaved by the C3bINA and β1H into two fragments: one of 60,000 (C3bα-60) and another of 40,000 (C3bα-40) daltons. The β-chain of C3b is unaffected by the C3bINA and β1H.
S K Law, Douglas T Fearon, R P Levine
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Determination of C3b Receptors
Archives of Surgery, 1985A method, devised in the authors' laboratories, for the determination of C3b receptors on normal and patient neutrophils using C3b-coated fluorescent microspheres, was applied to the quantitation of C3b receptors on the neutrophils of several patients suffering from burns and trauma and a patient with pancreatitis. From three to 11 days in the clinical
J D, Ogle +4 more
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Modulation of C3b Hemolytic Activity by a Plasma Protein Distinct from C3b Inactivator
Science, 1976A human plasma protein binds to cell-bound C3b, the major cleavage product of the third component of complement. Consequent upon this binding, C3b no longer functions in either the classical or alternative pathways. This C3b inhibitory activity is a property of a protein previously designated β1H on the basis of its electrophoretic mobility.
K, Whaley, S, Ruddy
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The Physiological Breakdown of C3b
The Journal of Immunology, 1978Abstract The requirements for and products of C3b inactivator (KAF) action on C3b have been studied. C3 was purified from human serum. Final traces of contaminating proteins were removed by passage through a Sepharose “anti-impurity antiserum” column.
R A Harrison, P J Lachmann
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Springer Seminars in Immunopathology, 1983
The C3b receptor of human erythrocytes, neutrophils, monocytes, all mature B cells, a subpopulation of T cells, and glomerular podocytes is a single chain glycoprotein that exists in two allotypic forms having Mr's of approximately 250,000 (F) and 260,000 (S).
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The C3b receptor of human erythrocytes, neutrophils, monocytes, all mature B cells, a subpopulation of T cells, and glomerular podocytes is a single chain glycoprotein that exists in two allotypic forms having Mr's of approximately 250,000 (F) and 260,000 (S).
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The Journal of Immunology, 1971
Abstract C3b inactivator (C3bINA), a normal serum protein that destroys the ability of cells bearing C3b to participate in immune adherence, to undergo enhanced phagocytosis by polymorphonuclear leukocytes and to react with subsequent components of the complement system, was studied.
Shaun Ruddy, K Frank Austen
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Abstract C3b inactivator (C3bINA), a normal serum protein that destroys the ability of cells bearing C3b to participate in immune adherence, to undergo enhanced phagocytosis by polymorphonuclear leukocytes and to react with subsequent components of the complement system, was studied.
Shaun Ruddy, K Frank Austen
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Modulation of neutrophil expression of C3b receptors (CR1) by soluble monomeric human C3b
European Journal of Immunology, 1987AbstractUpon incubation at 37°C with purified human C3b (500 μg/ml), polymorphonuclear neutrophils (PMN) were found to express up to 50% more C3b receptors (CR1) than PMN incubated with buffer alone. This up‐regulation of CR1, assessed by the binding of radiolabeled CR1‐specific monoclonal antibody, was dependent on the dose of C3b, occurred within 10 ...
F, Porteu +2 more
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C3b Inactivator: The Effect on Cell Bound C3b and a Simplified Functional Assay
The Journal of Immunology, 1978Abstract The activity of C3b inactivator on the cellular intermediate site EAC43b was compared in three test systems (a functional hemolytic assay, an immune adherence assay, and a functional radioimmunoassay). 125I-C3 was incubated with EAC142 to form EAC1423*. C1 was removed with EDTA and C2 was allowed to decay at 37°C C/1 hr.
Thelma A Gaither +2 more
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Detection of Anti-C3b Autoantibodies by ELISA
2021Autoantibodies against complement proteins are involved in the pathological process of many diseases, including lupus nephritis, C3 glomerulopathies, and atypical hemolytic uremic syndrome. This method describes the detection of autoantibodies targeting the central complement component C3 by ELISA.
Maria, Radanova +2 more
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Characterization of the human complement (c3b) receptor with a fluid phase C3b dimer.
The Journal of Immunology, 1981Abstract The interaction of C3b receptor with C3b, the major cleavage product of C3, elicits important biologic functions, such as enhanced phagocytosis and release of cellular enzymes. We determined the binding kinetics and binding isotherm of C3b-receptor interaction by using human cells and fluid phase C3b generated by trypsin ...
M A, Arnaout +3 more
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