Results 1 to 10 of about 6,868 (161)

Plasma C4d Correlates With C4d Deposition in Kidneys and With Treatment Response in Lupus Nephritis Patients [PDF]

Frontiers in Immunology, 2020
ObjectiveTo examine whether C4d plasma levels correlate with treatment response and C4d kidney deposition in systemic lupus erythematosus (SLE) with lupus nephritis (LN).MethodsC4d plasma levels were analyzed by a unique assay specifically detecting C4d ...
Myriam Martin, Myriam Martin, Rebecca Trattner, Rebecca Trattner, Sara C. Nilsson, Albin Björk, Agneta Zickert, Agneta Zickert, Anna M. Blom, Anna M. Blom, Iva Gunnarsson, Iva Gunnarsson   +11 more
doaj   +3 more sources

A Novel Perspective on Tubular C4d Positivity in BK Polyomavirus Nephropathy [PDF]

Kidney International Reports
Introduction: Tubular basement membrane (TBM) C4d staining has been frequently observed in BK polyomavirus nephropathy (BKPyVN); however, its specificity and clinical implications remain unclear.
Tong Wu, Fangzhou Guo, Shicong Yang, Zeying Jiang, Xianghong He, Qihua Wang, Zhixin Huang, Jue Wang, Zhenyu Xu, Meiyi Song, Xiaotao Hou, Gang Huang, Wenfang Chen   +12 more
doaj   +2 more sources

Association of C4d with disease activity in anti-neutrophil cytoplasmic antibody-associated vasculitis: evidence for classical/lectin complement pathway activation [PDF]

Arthritis Research & Therapy
Background We aimed to investigate the involvement of the classical/lectin complement pathway in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by exploring the complement activation fragment C4d in association to AAV activity ...
Anna Juto, Myriam Martin, Albin Björk, Leonid Padyukov, Caroline Grönwall, Aleksandra Antovic, Annette Bruchfeld, Iva Gunnarsson, Anna M. Blom   +8 more
doaj   +2 more sources

Distribution pattern of mesangial C4d deposits as predictor of kidney failure in IgA nephropathy.

PLoS ONE, 2021
Mesangial C4d deposits have been associated with worse outcomes in Western patients with IgA nephropathy (IgAN), but there is limited data in Asians.
Suchin Worawichawong, Sirithep Plumworasawat, Wisit Liwlompaisan, Vasant Sumethkul, Bunyong Phakdeekitcharoen, Umaporn Udomsubpayakul, Panus Chalermsanyakorn, Chagriya Kitiyakara   +7 more
doaj   +1 more source

Renal C4d is a potential biomarker of disease activity and severity in pediatric lupus nephritis patients

Frontiers in Pediatrics, 2023
BackgroundSystemic lupus erythematosus (SLE), a multisystemic autoimmune disease, is very aggressive in pediatric-onset patients as they are prone to develop lupus nephritis (LN).
Xueyao Wang, Shaojie Fu, Jinyu Yu, Daru Tang, Hao Wu, Zhonggao Xu   +5 more
doaj   +1 more source

Clinicopathological Correlation with Mesangial C4d Deposition in Primary Immunoglobulin A Nephropathy - A Descriptive study

Saudi Journal of Kidney Diseases and Transplantation, 2021
In immunoglobulin A (IgA) nephropathy, activation of lectin pathway leads to severe renal damage and more pronounced histological damage. As C4d is a marker of lectin pathway activation, the presence of mesangial C4d positivity will help in identifying ...
Gnanapriya Vellaisamy, Renuka Malipatel, S Renuka, Pritilata Rout   +3 more
doaj   +1 more source

The Spectrum of C4d Deposition in Renal Biopsies of Lupus Nephritis Patients

Frontiers in Immunology, 2021
ObjectivesThis study aimed to determine the prevalence and localization of complement factor C4d in renal biopsies from patients with lupus nephritis (LN), as well as its associations with the disease’s clinico-pathological features.
Ying Ding, Ying Ding, Xiaojuan Yu, Lihua Wu, Ying Tan, Zhen Qu, Feng Yu, Feng Yu   +7 more
doaj   +1 more source

C4d as a Screening Tool and an Independent Predictor of Clinical Outcomes in Lupus Nephritis and IgA Nephropathy

Frontiers in Medicine, 2022
BackgroundAs an indispensable marker of complement cascades activation, C4d was confirmed of its crucial role in the pathogenesis of both lupus nephritis (LN) and IgA nephropathy (IgAN).
Xiaoqian Yang, Yanhong Yuan, Xinghua Shao, Huihua Pang, Xiajing Che, Liou Cao, Minfang Zhang, Yao Xu, Zhaohui Ni, Chaojun Qi, Qin Wang, Shan Mou   +11 more
doaj   +1 more source

Clinical significance of C4d deposition in renal tissues from patients with primary Sjögren’s syndrome—a preliminary study

BMC Nephrology, 2019
Background To evaluate renal expression of C4d, a complement component in the classical/mannose binding lectin (MBL) pathway, in patients with primary Sjögren’s syndrome (pSS)-associated renal impairments. Methods We retrospectively reviewed the clinical
Wenli Xia, Bixia Gao, Lin Duan, Yan Li, Yubing Wen, Limeng Chen, Xuemei Li, Falei Zheng, Mingxi Li   +8 more
doaj   +1 more source

C4d in lupus nephritis and correlation with clinicopathologic findings [PDF]

Journal of Nephropathology, 2018
Background: Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE). Activation of complement system which leads to the production of C4 and its ultimate product, C4d, plays an important role in the pathogenesis of LN ...
Tahereh Malakoutian, Atefeh Amouzegar, Mojgan Asgari, Tina Shooshtarizadeh   +3 more
doaj   +1 more source