Results 21 to 30 of about 6,868 (161)

Utility of C4D deposits in native renal diseases and relation with disease progression

Indian Journal of Health Sciences and Biomedical Research KLEU, 2019
INTRODUCTION: C4D is a well-known biomarker of complement cascade. The utility of C4D in identification of antibody-mediated rejection has been known since its incorporation in Banff classification in 2003.
Sucheta Yadav, Atin Singhai, Suresh Babu, Vijay Kumar Singh, Anupam Wakhlu, Satyendra Sonkar, Bhupendra Pal Singh, Chanchal Rana   +7 more
doaj   +1 more source

Renal Transplant Patients Biopsied for Cause and Tested for C4d, DSA, and IgG Subclasses and C1q: Which Humoral Markers Improve Diagnosis and Outcomes?

Journal of Immunology Research, 2017
The association between donor specific antibodies (DSA) and renal transplant rejection has been generally established, but there are cases when a DSA is present without rejection.
James C. Cicciarelli, Nathan A. Lemp, Youngil Chang, Michael Koss, Katrin Hacke, Noriyuki Kasahara, Kevin M. Burns, David I. Min, Robert Naraghi, Tariq Shah   +9 more
doaj   +1 more source

Donor-specific antibodies, glomerulitis, and human leukocyte antigen B eplet mismatch are risk factors for peritubular capillary C4d deposition in renal allografts

Chinese Medical Journal, 2021
. Background:. The complement system plays an important role in the immune response to transplantation, and the diagnostic significance of peritubular capillary (PTC) C4d deposition (C4d+) in grafts is controversial.
Jin Zheng, Hui Guo, Hui-Lin Gong, Ping Lan, Chen-Guang Ding, Yang Li, Xiao-Ming Ding, Wu-Jun Xue, Yuan-Yuan Ji   +8 more
doaj   +1 more source

Mesangial C4d Deposits in Early IgA Nephropathy [PDF]

Clinical Journal of the American Society of Nephrology, 2017
Background and objectives The prognostic value of mesangial C4d deposits in IgA nephropathy has been analyzed in patients with reduced GFR but has not been analyzed in those with normal kidney function. The main objective of the study was to analyze the prognostic value of C4d deposits and association with response to treatment
Alfons, Segarra, Katheryne, Romero, Irene, Agraz, Natalia, Ramos, Alvaro, Madrid, Clara, Carnicer, Elias, Jatem, Ramón, Vilalta, Luis Enrique, Lara, Elena, Ostos, Naiara, Valtierra, Juliana, Jaramillo, Karla V, Arredondo, Gema, Ariceta, Cristina, Martinez   +14 more
openaire   +2 more sources

Role of complement activation product C4d as a predictor biomarker in lung cancer diagnosis: a case–control study

Egyptian Journal of Chest Disease and Tuberculosis, 2021
Background Molecular biomarkers such as complement C4d in bronchoalveolar lavage (BAL) may interfere with lung cancer diagnosis. However, limited studies have been conducted.
Lucy A El-Maboud Suliman, Amr A Moawad, Heba Elshahawy, Dina A Abdalla   +3 more
doaj   +1 more source

Prognostic Value of C4d Immunolabelling in Adult Patients With IgA Vasculitis

Frontiers in Medicine, 2021
Background and Objectives: Glomerular C4d deposits are associated the severity and outcomes of IgA nephropathy. Whether this holds true in immunoglobulin A vasculitis (IgAV) is not known.
Anais Romero, Fanny Drieux, Arnaud François, Alexandra Dervaux, Xiao Li Xu, Dimitri Titeca-Beauport, Dominique Bertrand, Dominique Guerrot, Dominique Guerrot   +8 more
doaj   +1 more source

Significance of C4d expression in peritubular capillaries concurrent with microvascular inflammation in for-cause biopsies of ABO-incompatible renal allografts [PDF]

Kidney Research and Clinical Practice
Background Pathologic diagnosis of antibody-mediated rejection (ABMR) in ABO-incompatible (ABOi) transplantation patients is often challenging because patients without ABMR are frequently immunopositive for C4d.
Haeyon Cho, Chung Hee Baek, Su-Kil Park, Hyosang Kim, Heounjeong Go   +4 more
doaj   +1 more source

Molecular Assessment of C4d-Positive Renal Transplant Biopsies Without Evidence of Rejection

Kidney International Reports, 2019
Introduction: Immunohistochemical staining for C4d in peritubular capillaries has been part of antibody-mediated rejection (AbMR) definition in the Banff Classification for Allograft Pathology since 2003.
Katherine M. Dominy, Michelle Willicombe, Tariq Al Johani, Hannah Beckwith, Dawn Goodall, Paul Brookes, H. Terence Cook, Tom Cairns, Adam McLean, Candice Roufosse   +9 more
doaj   +1 more source

Potential Roles of Antiphospholipid Antibodies in Generating Platelet-C4d in Systemic Lupus Erythematosus

Antibodies, 2017
Premature, accelerated onset of atherothrombotic disease is prevalent in patients with systemic lupus erythematosus (SLE). Most, if not all, atherothrombotic diseases are likely to involve platelets and complement.
Chau-Ching Liu, Travis Schofield, Amy Tang, Susan Manzi, Joseph M. Ahearn   +4 more
doaj   +1 more source

Immunohistochemical evaluation of C4d and C3d markers in bullous pemphigoid as a substitute for direct immunofluorescence technique

Indian Journal of Dermatology, 2023
Background: There are several methods for the diagnosis of autoimmune bullous disease. Direct immunofluorescent (DIF) testing is an important diagnostic method in the diagnosis of immunobullous disease but requires skilled pathologist, fresh tissue and ...
Mahsa Akbari Oryani, Naser Tayebi-Meybodi, Yalda Nahidi, Mohsen Soltani Sabi, Monavar Afzal Aghaei   +4 more
doaj   +1 more source