Results 191 to 200 of about 53,790 (237)

Avacopan is effective in inducing remission for MPA/GPA, regardless of changes in serum C5a levels: a single-center study in Japan. [PDF]

BMC Rheumatol
Ushio Y, Shimada H, Wakiya R, Nakashima S, Miyagi T, Sugihara K, Mino R, Mizusaki M, Chujo K, Manabe N, Kadowaki N, Dobashi H.   +11 more
europepmc   +1 more source

Impact of complement system proteins on the clinical progression of hospitalized patients with COVID-19. [PDF]

BMC Infect Dis
de Andrade LV, Vasconcelos B, Khouri R, de Souza CDF, Armstrong ADC, do Carmo RF.   +5 more
europepmc   +1 more source

ACSL4 Drives C5a/C5aR1-Calcium-Induced Fibroblast-to-Myofibroblast Transition in a Bleomycin-Induced Mouse Model of Pulmonary Fibrosis. [PDF]

Biomolecules
Ren T, Shi J, Zhuang L, Su R, Lai Y, Yang N.   +5 more
europepmc   +1 more source

Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications. [PDF]

Front Immunol
Liang X, Li Y, Tang Z, Luo Y, Liu Y.
europepmc   +1 more source

Complement activation in immunological neurological disorders: mechanisms and therapeutic strategies. [PDF]

Front Neurol
Chen JY, Sanghani N, Palmer K, Li Y, Lin F, Abbatemarco JR.   +5 more
europepmc   +1 more source

C5a-Induced Autophagy Dysfunction Promotes Choroidal Neovascularization Through the ROS-Inflammatory Pathway. [PDF]

Invest Ophthalmol Vis Sci
Du Y, Feng L, Tang J, Qin X, Bai B, Liang L.   +5 more
europepmc   +1 more source

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Human C5a and C5a analogs as probes of the neutrophil C5a receptor

Molecular Immunology, 1980
Abstract Quantitative assessment of the human neutrophil chemotactic response and immunologic evidence demonstrate that human C5a and/or its physiological equivalent, C5a des Arg' serves as the predominant chemotactic factor in complement activated serum.
D E, Chenoweth, T E, Hugli
openaire   +2 more sources

Complement component 5a (C5a)

The International Journal of Biochemistry & Cell Biology, 2009
The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert
Manthey, Helga D., Woodruff, Trent M., Taylor, Stephen M., Monk, Peter N.   +3 more
openaire   +3 more sources

Tc-99m-labeled C5a and C5a des Arg74 for infection imaging

Nuclear Medicine and Biology, 2003
The complement anaphylatoxin C5a and its natural metabolite C5a des Arg(74) (C5adR) are involved in several stages of the inflammatory process. Both act on a common receptor expressed on different cell types, including neutrophils and monocytes. The receptor binding affinity of C5a is in the nanomolar range and exceeds that of C5adR by 1-2 orders of ...
Rennen, H. J., Oyen, W. J., Cain, S. A., Monk, P. N., Corstens, F. H., Boerman, O. C.   +5 more
openaire   +4 more sources