Trends in Ocean S‐Isotopes May Be Influenced by Major LIP Events
Geophysical Monograph Series, Page 341-376., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Ross. R. Large +5 more
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Inhibiting the C5-C5a receptor axis [PDF]
, 2011 Activation of the complement system is a major pathogenic event that drives various inflammatory responses in numerous diseases. All pathways of complement activation lead to cleavage of the C5 molecule generating the anaphylatoxin C5a and, C5b that ...
Francesco Tedesco +5 more
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Increased local concentration of complement C5a contributes to incisional pain in mice
Journal of Neuroinflammation, 2011 Background In our previous study, we demonstrated that local injection of complement C5a and C3a produce mechanical and heat hyperalgesia, and that C5a and C3a activate and sensitize cutaneous nociceptors in normal skin, suggesting a contribution of ...
Clark David J +5 more
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Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
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C5a generated by bacteria in CF sols. [PDF]
, 2016 (A) C5a concentrations in sol fractions from sputum of CF patients (n = 3) or controls (n = 3) before and after incubation with live or dead P. aeruginosa or S. aureus. Data are means ± SE. C5a was generated in CF sol in the presence of P. aeruginosa (P =
Tushar A. Shah (834680) +5 more
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p38MAPK, ERK and PI3K signaling pathways are involved in C5a-primed neutrophils for ANCA-mediated activation. [PDF]
PLoS ONE, 2012 BACKGROUND: The complement system is one of the important contributing factors in the development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
Jian Hao +4 more
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Advanced Science, EarlyView.A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li +13 more
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Allosterism in human complement component 5a (hC5a): a damper of C5a receptor (C5aR) signaling [PDF]
, 2015 The phenomena of allosterism continues to advance the field of drug discovery, by illuminating gainful insights for many key processes, related to the structure–function relationships in proteins and enzymes, including the transmembrane G-protein coupled
Soumendra Rana (775641) +2 more
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Complement Activation in Arterial and Venous Thrombosis is Mediated by Plasmin
EBioMedicine, 2016 Thrombus formation leading to vaso-occlusive events is a major cause of death, and involves complex interactions between coagulation, fibrinolytic and innate immune systems.
Jonathan H. Foley +8 more
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Updatable Closed‐Form Evaluation of Arbitrarily Complex Multiport Network Connections
Advanced Electronic Materials, EarlyView.The inverse design of electrically large wave devices often uses reduced‐order multiport models with discrete optimization, requiring many evaluations of complex interconnections between subsystems that differ only in a few blocks. This paper introduces a closed‐form framework enabling efficient Woodbury low‐rank updates of related, previous ...
Hugo Prod'homme, Philipp del Hougne
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