Results 41 to 50 of about 6,229 (213)

Increased local concentration of complement C5a contributes to incisional pain in mice

Journal of Neuroinflammation, 2011
Background In our previous study, we demonstrated that local injection of complement C5a and C3a produce mechanical and heat hyperalgesia, and that C5a and C3a activate and sensitize cutaneous nociceptors in normal skin, suggesting a contribution of ...
Clark David J, Sun Yuan, Kido Kanta, Liang Deyong, Jang Jun H, Brennan Timothy J   +5 more
doaj   +1 more source

Anti-C5a treatment ameliorated sepsis.

, 2013
(A) Anti-C5a antibody blocked the C5a effect. 100 nM mouse C5a and 100 nM preimmune IgG or anti-C5a were incubated for 2 hours at room temperature. Peripheral blood cells (PBMC) were collected from 7-week-old mice and diluted 2 times the volume of whole ...
Chen Xing (436152), Chunmei Hou (291664), Renxi Wang (291661), Yujuan Wang (436153), Yi Wang (32470), Ke Wang (82395), He Xiao (291662), Bernadette Marrero (306601), Ning Ma (155058), Yan Li (23143), Guojiang Chen (291667), Gencheng Han (291658), Beifen Shen (78998)   +12 more
core   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

p38MAPK, ERK and PI3K signaling pathways are involved in C5a-primed neutrophils for ANCA-mediated activation. [PDF]

PLoS ONE, 2012
BACKGROUND: The complement system is one of the important contributing factors in the development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
Jian Hao, Li-Qiang Meng, Peng-Cheng Xu, Min Chen, Ming-Hui Zhao   +4 more
doaj   +1 more source

Assessment of interleukin-17A, C5a and RANTES for early diagnosis of neonatal sepsis – a preliminary study

, 2017
The aim of the present study was to investigate serum levels of novel markers: interleukin 17A (IL-17A), anaphylatoxin C5a and chemokine regulated upon activation normal T-cell expressed and secreted (RANTES) in neonates with clinically suspected early ...
Justyna Tołłoczko, Ewa Piotrowska, Katarzyna Dzierżanowska-Fangrat, Maria K. Borszewska-Kornacka, Hanna Gregorek, Beata Kasztelewicz   +5 more
core   +1 more source

Updatable Closed‐Form Evaluation of Arbitrarily Complex Multiport Network Connections

Advanced Electronic Materials, EarlyView.
The inverse design of electrically large wave devices often uses reduced‐order multiport models with discrete optimization, requiring many evaluations of complex interconnections between subsystems that differ only in a few blocks. This paper introduces a closed‐form framework enabling efficient Woodbury low‐rank updates of related, previous ...
Hugo Prod'homme, Philipp del Hougne
wiley   +1 more source

Novel Haemodynamic effects of recombinant C5a and C5a des Arg in rats and mice

, 2008
Sepsis is defined as the body's response to an infection, characterised by an overwhelming release of inflammatory mediators, haemodynamic changes and cardiac dysfunction.
Monk, Peter, Shiels, Ian, Taylor, Stephen, Manthey, Helga, Moore, Tyson, Woodruff, Trent   +5 more
core   +1 more source

Complement Activation in Arterial and Venous Thrombosis is Mediated by Plasmin

EBioMedicine, 2016
Thrombus formation leading to vaso-occlusive events is a major cause of death, and involves complex interactions between coagulation, fibrinolytic and innate immune systems.
Jonathan H. Foley, Bethany L. Walton, Maria M. Aleman, Alice M. O'Byrne, Victor Lei, Micaela Harrasser, Kimberley A. Foley, Alisa S. Wolberg, Edward M. Conway   +8 more
doaj   +1 more source

HSV neutralization by the microbicidal candidate C5A [PDF]

, 2011
Genital herpes is a major risk factor in acquiring human immunodeficiency virus type-1 (HIV-1) infection and is caused by both Herpes Simplex virus type 1 (HSV-1) and HSV-2.
Philippe A Gallay, Georges M. G. M. Verjans, Geijtenbeek, T.B.H., Verjans, Georges M. G. M., Geijtenbeek, Teunis B. H., Geijtenbeek, TBH, Verjans, G.M.G.M. (George), Teunis B. H. Geijtenbeek, van Loenen, F.B., Chatterji, U, Michael D Bobardt, Gallay, P.A. (Philippe), Witte, L. (Lot) de, Chatterji, U. (Udayan), Gallay Philippe A., Bobardt, MD, Chatterji Udayan, Chatterji, U., Verjans, Georges, van Loenen, Freek B., Bobardt, M.D., Loenen, F.B. (Freek) van, Georges M G M Verjans, Witte, Lot, Bobardt, M.D. (Michael), Udayan Chatterji, Gallay, Philippe A., Philippe A. Gallay, Loenen, Freek, Freek B. van Loenen, Chatterji, Udayan, Gallay, PA, Verjans Georges M. G. M., de Witte Lot, Verjans, G.M.G.M., Bobardt, Michael D., Geijtenbeek, T.B.H. (Teunis), de Witte, L., Gallay, P.A., Freek B van Loenen, Teunis B H Geijtenbeek, de Witte, Lot, Geijtenbeek Teunis B. H., Bobardt Michael D., van Loenen Freek B., Lot de Witte, Michael D. Bobardt   +46 more
core   +4 more sources

Complement C5a promotes antigen cross-presentation by Peyer’s patch monocyte-derived dendritic cells and drives a protective CD8+ T cell response

Cell Reports, 2021
Summary: The complement fragment C5a is closely associated with adaptive immune induction in the mucosa. However, the mechanisms that control CD8+ T cell responses by C5a have not been extensively explored.
Sae-Hae Kim, Byeol-Hee Cho, Kwang Soon Kim, Yong-Suk Jang   +3 more
doaj   +1 more source