Results 41 to 50 of about 51,606 (244)

9,9-Dimethyl-9-silafluorene [PDF]

, 2009
The title compound, C14H14Si, crystallizes with two almost identical molecules (r.m.s. deviation = 0.080 Å for all non-H atoms) in the asymmetric unit. All atoms of the silafluorene moiety lie in a common plane (r.m.s.
Jan Mewes, Hans-Wolfram Lerner, Michael Bolte, Blessing, Hudrlik, Kaufmann, Sheldrick, Spek   +7 more
core   +1 more source

Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections

Virulence, 2019
The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Marcel Muenstermann, Lea Strobel, Andreas Klos, Rick A. Wetsel, Trent M. Woodruff, Jörg Köhl, Kay O. Johswich   +6 more
doaj   +1 more source

Macrophage migration inhibitory factor is involved in antineutrophil cytoplasmic antibody-mediated activation of C5a-primed neutrophils

BMC Immunology, 2019
Background C5a is important for antineutrophil cytoplasmic antibody (ANCA)-mediated activation of neutrophils. The present study aimed to assess the role of macrophage migration inhibitory factor (MIF) in ANCA-mediated activation of C5a-primed ...
Jian Hao, Tiegang Lv, Liping Xu, Mao Ran, Kaili Wu   +4 more
doaj   +1 more source

Association of Pain with Plasma C5a in Patients with Neuromyelitis Optica Spectrum Disorders During Remission

Neuropsychiatric Disease and Treatment, 2022
Yanping Tong,1,2 Jie Liu,3 Tao Yang,1,2 Jingwen Wang,4 Tianyou Zhao,4 Yuezhi Kang,1,2 Yongping Fan1,2 1Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2Beijing
Tong Y, Liu J, Yang T, Wang J, Zhao T, Kang Y, Fan Y   +6 more
doaj  

Modulation of Neutrophil Activity by Soluble Complement Cleavage Products—An In-Depth Analysis

Cells, 2022
The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors.
Lisa Wohlgemuth, Alexander Elias Paul Stratmann, Frederik Münnich, Stefan Bernhard, Bertram Dietrich Thomaß, Finn Münnich, Adam Omar Khalaf Mohamed, Marco Mannes, Christoph Quirin Schmidt, Kristina Nilsson Ekdahl, Bo Nilsson, Michael Fauler, Karl Josef Föhr, Markus Huber-Lang, David Alexander Christian Messerer   +14 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Investigation of Association of Complement 5 Genetic Polymorphisms with Sepsis and Sepsis-Induced Inflammatory Responses

Journal of Inflammation Research, 2021
Kaidian Chen,1,* Yao Lin,1,* Yuchun Liu,1,* Shuanglin Liao,2 Ruoxuan Yang,1 Jiefeng Huang,1 Mingwei Xu,1 Junbing He1 1The Intensive Care Unit, Jieyang Affiliated Hospital, Sun Yat-sen University, Jieyang, Guangdong, People’s Republic of China;
Chen K, Lin Y, Liu Y, Liao S, Yang R, Huang J, Xu M, He J   +7 more
doaj  

Complement C5a‐triggered differentiated HL‐60 stimulates migration of THP‐1 monocytic leukocytes via secretion of CCL2

FEBS Open Bio, 2021
Leukocytes play an important role in vascular inflammation prior to atherosclerosis. In particular, monocyte adhesion and migration to the endothelium contribute to the development of vascular inflammation.
Syed Masudur Rahman Dewan, Mizuko Osaka, Michiyo Deushi, Masayuki Yoshida   +3 more
doaj   +1 more source

Use of a cAMP BRET Sensor to Characterize a Novel Regulation of cAMP by the Sphingosine 1-Phosphate/G13 Pathway [PDF]

, 2007
Regulation of intracellular cyclic adenosine 3',5'-monophosphate (cAMP) is integral in mediating cell growth, cell differentiation, and immune responses in hematopoietic cells. To facilitate studies of cAMP regulation we developed a BRET (bioluminescence
Collins, Julie, Davis, Richard, DeCamp, Dianne, Fraser, Iain, Hsueh, Robert, Jiang, Lily I., Lin, Keng-Mean, Rebres, Robert A., Roach, Tamara, Ross, Elliott M., Sternweis, Paul C., Taussig, Ronald   +11 more
core   +2 more sources

A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants

Emerging Microbes and Infections, 2023
Antivirals with broad coronavirus activity are important for treating high-risk individuals exposed to the constantly evolving SARS-CoV-2 variants of concern (VOCs) as well as emerging drug-resistant variants. We developed and characterized a novel class
Jimena Pérez-Vargas, Liam J. Worrall, Andrea D. Olmstead, Anh-Tien Ton, Jaeyong Lee, Ivan Villanueva, Connor A. H. Thompson, Svenja Dudek, Siobhan Ennis, Jason R. Smith, Tirosh Shapira, Joshua De Guzman, Shutong Gang, Fuqiang Ban, Marija Vuckovic, Michael Bielecki, Suzana Kovacic, Calem Kenward, Christopher Yee Hong, Danielle G. Gordon, Paul N. Levett, Mel Krajden, Richard Leduc, Pierre-Luc Boudreault, Masahiro Niikura, Mark Paetzel, Robert N. Young, Artem Cherkasov, Natalie C. J. Strynadka, François Jean   +29 more
doaj   +1 more source