Results 21 to 30 of about 6,229 (213)

C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. [PDF]

PLoS ONE, 2009
Placental malaria (PM) is a leading cause of maternal and infant mortality. Although the accumulation of parasitized erythrocytes (PEs) and monocytes within the placenta is thought to contribute to the pathophysiology of PM, the molecular mechanisms ...
Andrea Conroy, Lena Serghides, Constance Finney, Simon O Owino, Sanjeev Kumar, D Channe Gowda, W Conrad Liles, Julie M Moore, Kevin C Kain   +8 more
doaj   +1 more source

TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2 [PDF]

, 2011
TLR and complement activation ensures efficient clearance of infection. Previous studies documented synergism between TLRs and the receptor for the pro-inflammatory complement peptide C5a (C5aR/CD88), and regulation of TLR-induced pro-inflammatory ...
Morgan, Bryan Paul, Judith Hall, Mario O. Labéta, Colmont, Chantal Sophie, Anne-Catherine Raby, Nicholas Topley, Shah, Sanjoy, Laumonnier, Yves, Barbara Coles, Hall, Judith Elizabeth, Holst, Benjamin, Jörg Köhl, B. Paul Morgan, Raby, Anne-Catherine, Labeta, Mario Oscar, James Davies, Yves Laumonnier, Benjamin Holst, Coles, Barbara, Köhl, Jörg, Davies, James Anthony, Topley, Nicholas, Chantal Colmont, Sanjoy Shah   +23 more
core   +1 more source

Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections

Virulence, 2019
The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Marcel Muenstermann, Lea Strobel, Andreas Klos, Rick A. Wetsel, Trent M. Woodruff, Jörg Köhl, Kay O. Johswich   +6 more
doaj   +1 more source

The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. [PDF]

PLoS ONE, 2008
Sepsis remains a poorly understood, enigmatic disease. One of the cascades crucially involved in its pathogenesis is the complement system. Especially the anaphylatoxin C5a has been shown to have numerous harmful effects during sepsis.
Michael A Flierl, Daniel Rittirsch, Anthony J Chen, Brian A Nadeau, Danielle E Day, J Vidya Sarma, Markus S Huber-Lang, Peter A Ward   +7 more
doaj   +1 more source

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

Angewandte Chemie, EarlyView.
Bioactive superstructures are assembled via metal–phenolic‐mediated assembly on agarose templates, followed by modification with human serum albumin. These superstructures demonstrate high bilirubin adsorption efficiency, strong antibacterial activity, and anticoagulant activity, providing a strategy for the rational design of multifunctional blood ...
Po Wang, Jingqu Chen, Siying Chen, Binsha Peng, Zhifeng Zhou, Ling Zhang, Rui Xie, Xiaojie Ju, Wei Wang, Dawei Pan, Liangyin Chu, Frank Caruso, Zhuang Liu   +12 more
wiley   +2 more sources

Association of Pain with Plasma C5a in Patients with Neuromyelitis Optica Spectrum Disorders During Remission

Neuropsychiatric Disease and Treatment, 2022
Yanping Tong,1,2 Jie Liu,3 Tao Yang,1,2 Jingwen Wang,4 Tianyou Zhao,4 Yuezhi Kang,1,2 Yongping Fan1,2 1Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2Beijing
Tong Y, Liu J, Yang T, Wang J, Zhao T, Kang Y, Fan Y   +6 more
doaj  

The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.

Journal of Biological Chemistry, 1994
The binding domain of the human C5a receptor consists of two distinct and physically separable subsites. One of these sites binds the C-terminal 8 amino acids of C5a and is as yet undefined, while the second site lies in the N terminus of the receptor and interacts with the core of C5a. Two deletion mutants were prepared to probe the importance of this
J A, DeMartino, G, Van Riper, S J, Siciliano, C J, Molineaux, Z D, Konteatis, H, Rosen, M S, Springer   +6 more
openaire   +2 more sources

Exclusive Hydroformylation of Terminal Olefins: A Phosphorus‐Free Ruthenium System for the Selective Functionalization of Complex Mixtures

Angewandte Chemie, EarlyView.
Development of a phosphorus‐free Ru/DBU catalyst enabling highly chemo‐ and regioselective hydroformylation of terminal olefins, sparing internal double bonds. Optimization of reaction parameters, ligand effects, and substrate scope including industrial feedstocks was realized.
Mohamed Niyaz Vellala Syed Ali, Ida Ziccarelli, Dilver Peña Fuentes, Christoph Kubis, Robert Franke, Ralf Jackstell, Matthias Beller   +6 more
wiley   +2 more sources

Investigation of Association of Complement 5 Genetic Polymorphisms with Sepsis and Sepsis-Induced Inflammatory Responses

Journal of Inflammation Research, 2021
Kaidian Chen,1,* Yao Lin,1,* Yuchun Liu,1,* Shuanglin Liao,2 Ruoxuan Yang,1 Jiefeng Huang,1 Mingwei Xu,1 Junbing He1 1The Intensive Care Unit, Jieyang Affiliated Hospital, Sun Yat-sen University, Jieyang, Guangdong, People’s Republic of China;
Chen K, Lin Y, Liu Y, Liao S, Yang R, Huang J, Xu M, He J   +7 more
doaj  

Macrophage migration inhibitory factor is involved in antineutrophil cytoplasmic antibody-mediated activation of C5a-primed neutrophils

BMC Immunology, 2019
Background C5a is important for antineutrophil cytoplasmic antibody (ANCA)-mediated activation of neutrophils. The present study aimed to assess the role of macrophage migration inhibitory factor (MIF) in ANCA-mediated activation of C5a-primed ...
Jian Hao, Tiegang Lv, Liping Xu, Mao Ran, Kaili Wu   +4 more
doaj   +1 more source