Results 21 to 30 of about 28,519 (248)
Inactivation of C5a Anaphylatoxin by a Peptide That Is Complementary to a Region of C5a [PDF]
The Journal of Immunology, 2004 Abstract PL37 (RAARISLGPRCIKAFTE) is an antisense homology box peptide composed of aa 37–53 of C5a-anaphylatoxin and is considered to be the region essential for C5a function. Using a computer program, we designed the complementary peptides ASGAPAPGPAGPLRPMF (Pep-A) and ASTAPARAGLPRLPKFF (Pep-B).
Emiko, Fujita +5 more
openaire +2 more sources
HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB
Journal of Investigative Surgery, 2022 Objective We previously showed that HSP90 is involved in postconditioning cardioprotection by inhibiting complement C5a. Here, we investigated whether HSP90-mediated C5a/NF-κB inhibition is responsible for the cardioprotection conferred by liraglutide ...
Shi-Tao He +6 more
doaj +1 more source
The International Journal of Biological Markers, 2023 Introduction Complement C5a is an important component of the innate immune system. An increasing number of reports have revealed the relevance of C5a in tumor progression; however, its exact role in metastatic renal cell carcinoma (mRCC) remains unknown.
Changjun Yang +6 more
doaj +1 more source
Complement C5a acts as molecular adjuvant in fish by enhancing antibody response to soluble antigen [PDF]
, 2014 C5a, the most potent anaphylatoxin generated during complement activation, has important proinflammatory actions and has also been shown to enhance antigen-specific antibody response in mammals, thereby acting as a molecular adjuvant.
Li, Jun +4 more
core +1 more source
BMC Neurology, 2023 Background Alzheimer’s disease (AD) is a common cause of dementia. Serum complement factor 5a (C5a) is exceedingly implicated in AD. We explored the role of C5a levels in AD patients of different severity.
Zhilian Li +3 more
doaj +1 more source
A pro-inflammatory role of C5L2 in C5a-primed neutrophils for ANCA-induced activation. [PDF]
PLoS ONE, 2013 BACKGROUND:The complement system is crucial for the development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In particular, C5a and its receptor on neutrophils, CD88, play a central role.
Jian Hao +4 more
doaj +1 more source
Different concentrations of C5a affect human dental pulp mesenchymal stem cells differentiation
BMC Oral Health, 2021 Background During the process of deep decay, when decay approaches the pulp, an immune response is triggered inside the pulp, which activates the complement cascade.
Jie Liu +10 more
doaj +1 more source
Determination of C5a-specific antibody levels and C5a neutralization. [PDF]
, 2013 Anti-C5a antibody levels (A) in the sera collected from mice on day 35 immunized for CIA. As described in Fig. 1B, (BALB/c x B10.Q) F1 male mice (8 weeks old) received vaccination subcutaneously of 100 µg MBP-C5a or PBS emulsified in CFA at day −21 and ...
Åsa Jansson (360547) +5 more
core +1 more source
A recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis. [PDF]
PLoS ONE, 2010 OBJECTIVES: To develop and validate a recombinant vaccine to attenuate inflammation in arthritis by sustained neutralization of the anaphylatoxin C5a. METHODS: We constructed and expressed fusion protein of C5a and maltose binding protein.
Kutty Selva Nandakumar +7 more
doaj +1 more source
OncoImmunology, 2017 Cancer immunotherapy relies upon the ability of T cells to infiltrate tumors. The endothelium constitutes a barrier between the tumor and effector T cells, and the ability to manipulate local vascular permeability could be translated into effective ...
Andrea Facciabene +14 more
doaj +1 more source