Results 31 to 40 of about 6,229 (213)
Modulation of Neutrophil Activity by Soluble Complement Cleavage Products—An In-Depth Analysis
Cells, 2022 The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors.
Lisa Wohlgemuth +14 more
doaj +1 more source
FEBS Open Bio, 2021 Leukocytes play an important role in vascular inflammation prior to atherosclerosis. In particular, monocyte adhesion and migration to the endothelium contribute to the development of vascular inflammation.
Syed Masudur Rahman Dewan +3 more
doaj +1 more source
Functions of C5a receptors [PDF]
Journal of Molecular Medicine, 2009 The split product of the complement protein, C5, is C5a and is an extremely potent pro-inflammatory peptide that interacts with two C5a receptors, C5aR and C5L2, present on surfaces of phagocytes as well as other cell types. The former is a well-established receptor that initiates G-protein-coupled signaling via mitogen-activated protein kinase ...
openaire +2 more sources
Emerging Microbes and Infections, 2023 Antivirals with broad coronavirus activity are important for treating high-risk individuals exposed to the constantly evolving SARS-CoV-2 variants of concern (VOCs) as well as emerging drug-resistant variants. We developed and characterized a novel class
Jimena Pérez-Vargas +29 more
doaj +1 more source
The Role of Formylpeptide Receptors, C5a Receptors, and Cytosolic-Free Calcium in Neutrophil Priming [PDF]
, 1990 Polymorphonuclear leukocytes (PMNL) exposed to chemoattractants or cytokines change their functional capacity. The effect of endotoxin-activated serum as a priming agent on human PMNL was tested.
W. Zimmerli +5 more
core +2 more sources
Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity. [PDF]
PLoS ONE, 2017 In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, inflammation and tissue destruction. The complement system is a major mediator of inflammation for many diseases with the effectors C5a and C3a often playing important
Pamela S Hair +5 more
doaj +1 more source
Determination of C5a-specific antibody levels and C5a neutralization.
, 2013 Anti-C5a antibody levels (A) in the sera collected from mice on day 35 immunized for CIA. As described in Fig. 1B, (BALB/c x B10.Q) F1 male mice (8 weeks old) received vaccination subcutaneously of 100 µg MBP-C5a or PBS emulsified in CFA at day −21 and ...
Åsa Jansson (360547) +5 more
core +1 more source
Aquaculture Reports, 2023 Death of grass carp (Ctenopharyngodon idella) caused by grass carp reovirus (GCRV) infection severely restricts the development of the grass carp industry.
Baohong Xu +8 more
doaj +1 more source
Leukocyte C5a receptor modulation during hemodialysis [PDF]
, 1987 Leukocyte C5a receptor modulation during hemodialysis. Exposure of blood to hemodialysis (HD) membranes results in the activation of the complement system.
Chenoweth, Dennis E. +5 more
core +1 more source
Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source