Results 31 to 40 of about 30,655 (265)

Modulation of Neutrophil Activity by Soluble Complement Cleavage Products—An In-Depth Analysis

Cells, 2022
The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors.
Lisa Wohlgemuth, Alexander Elias Paul Stratmann, Frederik Münnich, Stefan Bernhard, Bertram Dietrich Thomaß, Finn Münnich, Adam Omar Khalaf Mohamed, Marco Mannes, Christoph Quirin Schmidt, Kristina Nilsson Ekdahl, Bo Nilsson, Michael Fauler, Karl Josef Föhr, Markus Huber-Lang, David Alexander Christian Messerer   +14 more
doaj   +1 more source

Mapping of C5-Blocking Monoclonal Antibodies Reveals New C5 Inhibitory Epitopes and Novel Modes of C5 Inhibition. [PDF]

Immunology
We identify four distinct C5 inhibitory epitopes, including two novel antibodies that selectively block membrane attack complex (MAC) assembly while preserving C5 cleavage and C5a generation. These findings establish selective MAC inhibition as a new therapeutic strategy for complement‐mediated diseases.
Cooke RS, Lee KY, Menzies GE, Mizuno M, Morgan BP, Zelek WM.   +5 more
europepmc   +2 more sources

Complement C5a‐triggered differentiated HL‐60 stimulates migration of THP‐1 monocytic leukocytes via secretion of CCL2

FEBS Open Bio, 2021
Leukocytes play an important role in vascular inflammation prior to atherosclerosis. In particular, monocyte adhesion and migration to the endothelium contribute to the development of vascular inflammation.
Syed Masudur Rahman Dewan, Mizuko Osaka, Michiyo Deushi, Masayuki Yoshida   +3 more
doaj   +1 more source

Functions of C5a receptors [PDF]

Journal of Molecular Medicine, 2009
The split product of the complement protein, C5, is C5a and is an extremely potent pro-inflammatory peptide that interacts with two C5a receptors, C5aR and C5L2, present on surfaces of phagocytes as well as other cell types. The former is a well-established receptor that initiates G-protein-coupled signaling via mitogen-activated protein kinase ...
openaire   +2 more sources

Complement C5a acts as molecular adjuvant in fish by enhancing antibody response to soluble antigen

, 2014
C5a, the most potent anaphylatoxin generated during complement activation, has important proinflammatory actions and has also been shown to enhance antigen-specific antibody response in mammals, thereby acting as a molecular adjuvant.
Li, Jun, LaPatra, Scott E., Sunyer, J. Oriol, Zhang, Yong-An, Wu, Nan   +4 more
core   +1 more source

A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants

Emerging Microbes and Infections, 2023
Antivirals with broad coronavirus activity are important for treating high-risk individuals exposed to the constantly evolving SARS-CoV-2 variants of concern (VOCs) as well as emerging drug-resistant variants. We developed and characterized a novel class
Jimena Pérez-Vargas, Liam J. Worrall, Andrea D. Olmstead, Anh-Tien Ton, Jaeyong Lee, Ivan Villanueva, Connor A. H. Thompson, Svenja Dudek, Siobhan Ennis, Jason R. Smith, Tirosh Shapira, Joshua De Guzman, Shutong Gang, Fuqiang Ban, Marija Vuckovic, Michael Bielecki, Suzana Kovacic, Calem Kenward, Christopher Yee Hong, Danielle G. Gordon, Paul N. Levett, Mel Krajden, Richard Leduc, Pierre-Luc Boudreault, Masahiro Niikura, Mark Paetzel, Robert N. Young, Artem Cherkasov, Natalie C. J. Strynadka, François Jean   +29 more
doaj   +1 more source

The Role of Formylpeptide Receptors, C5a Receptors, and Cytosolic-Free Calcium in Neutrophil Priming [PDF]

, 1990
Polymorphonuclear leukocytes (PMNL) exposed to chemoattractants or cytokines change their functional capacity. The effect of endotoxin-activated serum as a priming agent on human PMNL was tested.
W. Zimmerli, Reber, Anne-Marie, C. A. Dahinden, Dahinden, Clemens A., Zimmerli, Werner, A.-M. Reber   +5 more
core   +2 more sources

Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity. [PDF]

PLoS ONE, 2017
In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, inflammation and tissue destruction. The complement system is a major mediator of inflammation for many diseases with the effectors C5a and C3a often playing important
Pamela S Hair, Laura A Sass, Turaj Vazifedan, Tushar A Shah, Neel K Krishna, Kenji M Cunnion   +5 more
doaj   +1 more source

Determination of C5a-specific antibody levels and C5a neutralization.

, 2013
Anti-C5a antibody levels (A) in the sera collected from mice on day 35 immunized for CIA. As described in Fig. 1B, (BALB/c x B10.Q) F1 male mice (8 weeks old) received vaccination subcutaneously of 100 µg MBP-C5a or PBS emulsified in CFA at day −21 and ...
Åsa Jansson (360547), Bingze Xu (360548), Kutty Selva Nandakumar (8484), Niclas Rydell (360549), Anna M. Blom (53233), Rikard Holmdahl (901)   +5 more
core   +1 more source

Pro-inflammatory regulatory mechanism of C5a/C5aR pathway in GCRV-infected grass carp (Ctenopharyngodon idella)

Aquaculture Reports, 2023
Death of grass carp (Ctenopharyngodon idella) caused by grass carp reovirus (GCRV) infection severely restricts the development of the grass carp industry.
Baohong Xu, Hang Su, Changjun Chen, Qiaolin Liu, Tiaoyi Xiao, Yi Liu, Zhao Lv, Hongquan Wang, Zheyu Wen   +8 more
doaj   +1 more source