Results 31 to 40 of about 28,519 (248)

Complement 3a and Complement 5a as Biochemical Markers in Diabetic Nephropathy [PDF]

International Journal of Medical Arts
Background: Diabetes mellitus [DM] is growing into a global epidemic and diabetic nephropathy [DN] is one of its most feared complications. Inflammation is an important mechanism in the pathogenesis of DN and many studies have pointed to anaphylatoxins ...
Safwat Ahmed, Alsayed Alsayed, Mohammed Aref, Ahmad Alkot   +3 more
doaj   +1 more source

By Increasing the Expression and Activation of STAT3, Sustained C5a Stimulation Increases the Proliferation, Migration, and Invasion of RCC Cells and Promotes the Growth of Transgrafted Tumors

Cancer Management and Research, 2021
Jing-Min Zheng,1,* Han-Xi Zhou,1,* Hong-Yuan Yu,1,* Yu-Hui Xia,2 Qing-Xin Yu,2 Hang-Shuai Qu,1 Jia-Qian Bao1 1Department of Urology, Taizhou Hospital, Wenzhou Medical University, Linhai, Zhejiang, People’s Republic of China; 2Department of ...
Zheng JM, Zhou HX, Yu HY, Xia YH, Yu QX, Qu HS, Bao JQ   +6 more
doaj  

Assessment of interleukin-17A, C5a and RANTES for early diagnosis of neonatal sepsis – a preliminary study [PDF]

, 2017
The aim of the present study was to investigate serum levels of novel markers: interleukin 17A (IL-17A), anaphylatoxin C5a and chemokine regulated upon activation normal T-cell expressed and secreted (RANTES) in neonates with clinically suspected early ...
Justyna Tołłoczko, Ewa Piotrowska, Katarzyna Dzierżanowska-Fangrat, Maria K. Borszewska-Kornacka, Hanna Gregorek, Beata Kasztelewicz   +5 more
core   +1 more source

Anti-C5a treatment ameliorated sepsis. [PDF]

, 2013
(A) Anti-C5a antibody blocked the C5a effect. 100 nM mouse C5a and 100 nM preimmune IgG or anti-C5a were incubated for 2 hours at room temperature. Peripheral blood cells (PBMC) were collected from 7-week-old mice and diluted 2 times the volume of whole ...
Chen Xing (436152), Chunmei Hou (291664), Renxi Wang (291661), Yujuan Wang (436153), Yi Wang (32470), Ke Wang (82395), He Xiao (291662), Bernadette Marrero (306601), Ning Ma (155058), Yan Li (23143), Guojiang Chen (291667), Gencheng Han (291658), Beifen Shen (78998)   +12 more
core   +1 more source

Novel Haemodynamic effects of recombinant C5a and C5a des Arg in rats and mice [PDF]

, 2008
Sepsis is defined as the body's response to an infection, characterised by an overwhelming release of inflammatory mediators, haemodynamic changes and cardiac dysfunction.
Monk, Peter, Shiels, Ian, Taylor, Stephen, Manthey, Helga, Moore, Tyson, Woodruff, Trent   +5 more
core   +1 more source

A disturbed balance between blood complement protective factors (FH, ApoE) and common pathway effectors (C5a, TCC) in acute COVID-19 and during convalesce

Scientific Reports, 2022
A complement effect on homeostasis during infection is determined by both cytotoxic (activate complement component 5 (C5a) terminal cytotoxic complex (TCC)), and cytoprotective elements (complement factor H (FH), as well as apolipoprotein E (ApoE)). Here,
Krzysztof Laudanski, Tony Okeke, Kumal Siddiq, Jihane Hajj, Mariana Restrepo, Damodar Gullipalli, Wen-chao Song   +6 more
doaj   +1 more source

C5a elevation in convalescents from severe COVID-19 is not associated with early complement activation markers C3bBbP or C4d

Frontiers in Immunology, 2022
Numerous publications have underlined the link between complement C5a and the clinical course of COVID-19. We previously reported that levels of C5a remain high in the group of severely ill patients up to 90 days after hospital discharge.
Daria Kowalska, Alicja Kuźniewska, Yaiza Senent, Yaiza Senent, Yaiza Senent, Beatriz Tavira, Beatriz Tavira, Beatriz Tavira, Susana Inogés, Susana Inogés, Susana Inogés, Ascensión López-Díaz de Cerio, Ascensión López-Díaz de Cerio, Ascensión López-Díaz de Cerio, Ruben Pio, Ruben Pio, Ruben Pio, Ruben Pio, Marcin Okrój, José Ramón Yuste, José Ramón Yuste, José Ramón Yuste   +21 more
doaj   +1 more source

C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. [PDF]

PLoS ONE, 2009
Placental malaria (PM) is a leading cause of maternal and infant mortality. Although the accumulation of parasitized erythrocytes (PEs) and monocytes within the placenta is thought to contribute to the pathophysiology of PM, the molecular mechanisms ...
Andrea Conroy, Lena Serghides, Constance Finney, Simon O Owino, Sanjeev Kumar, D Channe Gowda, W Conrad Liles, Julie M Moore, Kevin C Kain   +8 more
doaj   +1 more source

Functions of C5a receptors [PDF]

Journal of Molecular Medicine, 2009
The split product of the complement protein, C5, is C5a and is an extremely potent pro-inflammatory peptide that interacts with two C5a receptors, C5aR and C5L2, present on surfaces of phagocytes as well as other cell types. The former is a well-established receptor that initiates G-protein-coupled signaling via mitogen-activated protein kinase ...
openaire   +2 more sources

Weak response of porcine C5a receptor towards human C5a in miniature pig endothelial cells and PMNs [PDF]

, 2007
BACKGROUND: The anaphylatoxin C5a is a potent inflammatory molecule generated during complement activation. Although some reports have implicated C5a in xenograft rejection, to date, the molecular compatibility between human C5a and porcine C5a receptor (
Kim, Hyori, Cho, Bumrae, Chung, Junho, Hwang, Seung Yong, Kim, Ki Tae, Yang, Jaeseok, Ahn, Curie, Bae, Yoe-Sik, Yi, Kye Sook, Kang, Hee Jung, Kang, Yoon-Ho, Kim, Min Soo, Ha, Insu, Lee, Sukmook, Bang, Ki Tae   +14 more
core   +1 more source