Results 51 to 60 of about 28,519 (248)
Emerging Microbes and Infections, 2023 Antivirals with broad coronavirus activity are important for treating high-risk individuals exposed to the constantly evolving SARS-CoV-2 variants of concern (VOCs) as well as emerging drug-resistant variants. We developed and characterized a novel class
Jimena Pérez-Vargas +29 more
doaj +1 more source
Processing of C5a by human polymorphonuclear leukocytes [PDF]
, 1998 Uptake of human C5a by neutrophils was monitored in vitro using both 125I-labeled and unlabeled C5a. The ligand was internalized by the cells in a dose-dependent manner and maximal binding/uptake was observed after 5 min of incubation.
Geir Hetland +2 more
core +1 more source
Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity. [PDF]
PLoS ONE, 2017 In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, inflammation and tissue destruction. The complement system is a major mediator of inflammation for many diseases with the effectors C5a and C3a often playing important
Pamela S Hair +5 more
doaj +1 more source
Modeling Molecular Mechanisms of Binding of the Anaphylatoxin C5a to the C5a Receptor [PDF]
, 2016 This study presents the 3D model of the complex between the anaphylatoxin C5a and its specific receptor, C5aR. This is the first 3D model of a G-protein-coupled receptor (GPCR) complex with a peptide ligand deduced by a molecular modeling procedure ...
Garland R. Marshall (727036) +2 more
core +1 more source
Site‐specific mutations in the N‐terminal region of human C5a that affect interactions of C5a with the neutrophil C5a receptor [PDF]
Protein Science, 1993 AbstractC5a is an inflammatory mediator that evokes a variety of immune effector functions including chemotaxis, cell activation, spasmogenesis, and immune modulation. It is well established that the effector site in C5a is located in the C‐terminal region, although other regions in C5a also contribute to receptor interaction.
D F, Carney, T E, Hugli
openaire +2 more sources
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Aquaculture Reports, 2023 Death of grass carp (Ctenopharyngodon idella) caused by grass carp reovirus (GCRV) infection severely restricts the development of the grass carp industry.
Baohong Xu +8 more
doaj +1 more source
Leukocyte C5a receptor modulation during hemodialysis [PDF]
, 1987 Leukocyte C5a receptor modulation during hemodialysis. Exposure of blood to hemodialysis (HD) membranes results in the activation of the complement system.
Chenoweth, Dennis E. +5 more
core +1 more source
C5aR activation in the absence of C5a [PDF]
, 2022 S.696-704IgG Fc receptors (FcgRs) and the C5a anaphylatoxin receptor (C5aR) were identified as key regulators of type II autoimmune injury in mice. However, and with respect to C5aR, the relative importance of C5a for IgG autoantibody‐induced ...
Sogkas, G. +5 more
core +1 more source
FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis
Advanced Science, EarlyView.ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li +16 more
wiley +1 more source