Updatable Closed‐Form Evaluation of Arbitrarily Complex Multiport Network Connections
Advanced Electronic Materials, EarlyView.The inverse design of electrically large wave devices often uses reduced‐order multiport models with discrete optimization, requiring many evaluations of complex interconnections between subsystems that differ only in a few blocks. This paper introduces a closed‐form framework enabling efficient Woodbury low‐rank updates of related, previous ...
Hugo Prod'homme, Philipp del Hougne
wiley +1 more source
Novel Haemodynamic effects of recombinant C5a and C5a des Arg in rats and mice
, 2008 Sepsis is defined as the body's response to an infection, characterised by an overwhelming release of inflammatory mediators, haemodynamic changes and cardiac dysfunction.
Monk, Peter +5 more
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HSV neutralization by the microbicidal candidate C5A [PDF]
, 2011 Genital herpes is a major risk factor in acquiring human immunodeficiency virus type-1 (HIV-1) infection and is caused by both Herpes Simplex virus type 1 (HSV-1) and HSV-2.
Philippe A Gallay +46 more
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Arthritis &Rheumatology, EarlyView.Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source
Complement Activation Linked to Type II Interferon Signaling in Still Disease
Arthritis &Rheumatology, EarlyView.Objective Still disease (SD) is an autoinflammatory syndrome characterized by innate immune dysregulation. Although complement can drive inflammation, its involvement in SD remains to be defined. Thus, we aimed to assess complement activation in SD. Methods Complement was assessed using transcriptomic, proteomic, and in vitro approaches. RNA sequencing
Freya M. C. H. Huijsmans +115 more
wiley +1 more source
Weak response of porcine C5a receptor towards human C5a in miniature pig endothelial cells and PMNs
, 2007 BACKGROUND: The anaphylatoxin C5a is a potent inflammatory molecule generated during complement activation. Although some reports have implicated C5a in xenograft rejection, to date, the molecular compatibility between human C5a and porcine C5a receptor (
Kim, Hyori +14 more
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Navigating adverse immunostimulation: A practical guide for clinical researchers
British Journal of Clinical Pharmacology, EarlyView.Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort +3 more
wiley +1 more source
Trends in Ocean S‐Isotopes May Be Influenced by Major LIP Events
Geophysical Monograph Series, Page 341-376., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Ross. R. Large +5 more
wiley +1 more source
BMEMat, EarlyView.Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu +10 more
wiley +1 more source
Studies on the role of inflammation and stem cells in cardiac ischaemic injury [PDF]
, 2008 The regenerative capacity of human myocardium is unable to compensate adequately forth significant loss of heart muscle that occurs in acute myocardial infarction (Ml).
Ahmed, Ishtiaq M., Ahmed, Ishtiaq M
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