Results 11 to 20 of about 6,229 (213)

A pro-inflammatory role of C5L2 in C5a-primed neutrophils for ANCA-induced activation. [PDF]

PLoS ONE, 2013
BACKGROUND:The complement system is crucial for the development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In particular, C5a and its receptor on neutrophils, CD88, play a central role.
Jian Hao, Chen Wang, Jun Yuan, Min Chen, Ming-Hui Zhao   +4 more
doaj   +1 more source

Correlation of serum complement factor 5a level with inflammatory response and cognitive function in patients with Alzheimer’s disease of different severity

BMC Neurology, 2023
Background Alzheimer’s disease (AD) is a common cause of dementia. Serum complement factor 5a (C5a) is exceedingly implicated in AD. We explored the role of C5a levels in AD patients of different severity.
Zhilian Li, Huifang Wu, Yi Luo, Xianpei Tan   +3 more
doaj   +1 more source

Different concentrations of C5a affect human dental pulp mesenchymal stem cells differentiation

BMC Oral Health, 2021
Background During the process of deep decay, when decay approaches the pulp, an immune response is triggered inside the pulp, which activates the complement cascade.
Jie Liu, Xiaoling Wei, Junlong Hu, Xiaohan Tan, Xiaocui Kang, Li Gao, Ning Li, Xin Shi, Mengtong Yuan, Weiping Hu, Mingyue Liu   +10 more
doaj   +1 more source

A recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis. [PDF]

PLoS ONE, 2010
OBJECTIVES: To develop and validate a recombinant vaccine to attenuate inflammation in arthritis by sustained neutralization of the anaphylatoxin C5a. METHODS: We constructed and expressed fusion protein of C5a and maltose binding protein.
Kutty Selva Nandakumar, Asa Jansson, Bingze Xu, Niclas Rydell, Parvin Ahooghalandari, Lars Hellman, Anna M Blom, Rikard Holmdahl   +7 more
doaj   +1 more source

Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy

OncoImmunology, 2017
Cancer immunotherapy relies upon the ability of T cells to infiltrate tumors. The endothelium constitutes a barrier between the tumor and effector T cells, and the ability to manipulate local vascular permeability could be translated into effective ...
Andrea Facciabene, Francesco De Sanctis, Stefano Pierini, Edimara S. Reis, Klara Balint, John Facciponte, Jens Rueter, Masahiro Kagabu, Paola Magotti, Evripidis Lanitis, Robert A. DeAngelis, Ronald J. Buckanovich, Wenchao C. Song, John D. Lambris, George Coukos   +14 more
doaj   +1 more source

Complement 3a and Complement 5a as Biochemical Markers in Diabetic Nephropathy [PDF]

International Journal of Medical Arts
Background: Diabetes mellitus [DM] is growing into a global epidemic and diabetic nephropathy [DN] is one of its most feared complications. Inflammation is an important mechanism in the pathogenesis of DN and many studies have pointed to anaphylatoxins ...
Safwat Ahmed, Alsayed Alsayed, Mohammed Aref, Ahmad Alkot   +3 more
doaj   +1 more source

By Increasing the Expression and Activation of STAT3, Sustained C5a Stimulation Increases the Proliferation, Migration, and Invasion of RCC Cells and Promotes the Growth of Transgrafted Tumors

Cancer Management and Research, 2021
Jing-Min Zheng,1,* Han-Xi Zhou,1,* Hong-Yuan Yu,1,* Yu-Hui Xia,2 Qing-Xin Yu,2 Hang-Shuai Qu,1 Jia-Qian Bao1 1Department of Urology, Taizhou Hospital, Wenzhou Medical University, Linhai, Zhejiang, People’s Republic of China; 2Department of ...
Zheng JM, Zhou HX, Yu HY, Xia YH, Yu QX, Qu HS, Bao JQ   +6 more
doaj  

A disturbed balance between blood complement protective factors (FH, ApoE) and common pathway effectors (C5a, TCC) in acute COVID-19 and during convalesce

Scientific Reports, 2022
A complement effect on homeostasis during infection is determined by both cytotoxic (activate complement component 5 (C5a) terminal cytotoxic complex (TCC)), and cytoprotective elements (complement factor H (FH), as well as apolipoprotein E (ApoE)). Here,
Krzysztof Laudanski, Tony Okeke, Kumal Siddiq, Jihane Hajj, Mariana Restrepo, Damodar Gullipalli, Wen-chao Song   +6 more
doaj   +1 more source

C5a elevation in convalescents from severe COVID-19 is not associated with early complement activation markers C3bBbP or C4d

Frontiers in Immunology, 2022
Numerous publications have underlined the link between complement C5a and the clinical course of COVID-19. We previously reported that levels of C5a remain high in the group of severely ill patients up to 90 days after hospital discharge.
Daria Kowalska, Alicja Kuźniewska, Yaiza Senent, Yaiza Senent, Yaiza Senent, Beatriz Tavira, Beatriz Tavira, Beatriz Tavira, Susana Inogés, Susana Inogés, Susana Inogés, Ascensión López-Díaz de Cerio, Ascensión López-Díaz de Cerio, Ascensión López-Díaz de Cerio, Ruben Pio, Ruben Pio, Ruben Pio, Ruben Pio, Marcin Okrój, José Ramón Yuste, José Ramón Yuste, José Ramón Yuste   +21 more
doaj   +1 more source

Increased Levels of C5a in Gingival Crevicular Fluid and Saliva of Patients with Periodontal Disease

, 2022
C5a is a powerful complement effector molecule that is considered to be an important proinflammatory mediator in several systemic chronic inflammatory diseases. However, its levels in periodontal diseases are yet to be assessed.
Simran Preet Bhalla, Shaju, Ann Maria, Miranda, Leticia Algarves, Carlos Marcelo da Silva Figueredo, da Silva Figueredo, Carlos Marcelo, Figueredo, Carlos Marcelo da Silva, Leticia Algarves Miranda, Bhalla, Simran Preet, Ann Maria Shaju   +8 more
core   +1 more source