New insights for C5a and C5a receptors in sepsis [PDF]
Frontiers in Immunology, 2012 The complement system plays a central role in inflammation and immunity. Among the complement activation products, C5a is one of the most potent inflammatory peptides with a broad spectrum of functions.
Hongwei eGao, Chunguang eYan
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Macrophages self-generate and refine chemotactic gradients during migration towards complement C5a. [PDF]
PLoS BiologyMacrophages rely on efficient chemotaxis to locate sites of infection and tissue damage. One general strategy that enhances chemotactic accuracy is the use of self-generated gradients, where cells locally deplete attractants to create or sharpen guidance
Abhimanyu Kiran +11 more
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The free fatty acid 2 receptor regulates C5a induced neutrophil superoxide production and its sensitivity to inhibition by the antagonist avacopan [PDF]
Frontiers in ImmunologyIntroductionReceptor transactivation is a novel signaling mechanism used by several different neutrophil G protein-coupled receptors (GPCRs) to activate an allosterically modulated receptor that recognizes short chain free fatty acids.
Zahra Khan +8 more
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The effect of various forms of treatment of vasculitis on C3, C4 and C5a complement levels in infants and children attending Assiut University Children Hospital (AUCH) [PDF]
E3S Web of Conferences, 2023 Vasculitis is an umbrella term for various and heterogeneous disorders sharing the presence of inflammation of blood vessel walls (Geetha & Jefferson, 2020).
Fatthi Dalal Abdullah
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Open Medicine, 2021 Activation of the complement component 5a (C5a) and nuclear factor κB (NF-κB) signaling is an important feature of myocardial ischemia/reperfusion (I/R) injury and recent studies show that morphine postconditioning (MP) attenuates the myocardial injury ...
Tu Rong-Hui +7 more
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Virulence, 2022 Cystic fibrosis (CF) disease is characterized by an intense airway inflammatory response mediated by neutrophils and chronic respiratory infections caused by P. aeruginosa.
Margalida Mateu-Borrás +6 more
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Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody
Journal of Innate Immunity, 2023 Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer.
Leon Cyranka +6 more
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HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB
Journal of Investigative Surgery, 2022 Objective We previously showed that HSP90 is involved in postconditioning cardioprotection by inhibiting complement C5a. Here, we investigated whether HSP90-mediated C5a/NF-κB inhibition is responsible for the cardioprotection conferred by liraglutide ...
Shi-Tao He +6 more
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The International Journal of Biological Markers, 2023 Introduction Complement C5a is an important component of the innate immune system. An increasing number of reports have revealed the relevance of C5a in tumor progression; however, its exact role in metastatic renal cell carcinoma (mRCC) remains unknown.
Changjun Yang +6 more
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Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge
Frontiers in Immunology, 2021 Evidence supports a role of complement anaphylatoxin C5a in the pathophysiology of COVID-19. However, information about the evolution and impact of C5a levels after hospital discharge is lacking. We analyzed the association between circulating C5a levels
Yaiza Senent +35 more
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