Influence of 17 beta-estradiol, progesterone, and dexamethasone on diapedesis and viability of bovine blood polymorphonuclear leukocytes [PDF]
, 2004 The aim of the current study was to investigate whether polymorphonuclear leukocyte (PMN) diapedesis and viability are influenced by steroid hormones.
Burvenich, Christian +3 more
core +1 more source
Ibrain, EarlyView.In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard +2 more
wiley +1 more source
Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
Journal of Neuroinflammation, 2022 Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, recruitment of ...
Klebea Carvalho +10 more
doaj +1 more source
Increased local concentration of complement C5a contributes to incisional pain in mice
Journal of Neuroinflammation, 2011 Background In our previous study, we demonstrated that local injection of complement C5a and C3a produce mechanical and heat hyperalgesia, and that C5a and C3a activate and sensitize cutaneous nociceptors in normal skin, suggesting a contribution of ...
Clark David J +5 more
doaj +1 more source
Beyond feasibility filters: How expertise heterogeneity enables innovation recognition
Strategic Management Journal, EarlyView.Abstract Research Summary Organizations often struggle to identify promising innovations that balance novelty and feasibility in multidisciplinary domains, yet how does evaluator expertise heterogeneity shape these assessments? This study examines how evaluator expertise influences innovation evaluation through a field experiment with National ...
Jacqueline N. Lane +3 more
wiley +1 more source
Novel structural determinants of the human neutrophil chemotactic activity of leukotriene B. [PDF]
, 1981 A specific 5(S),12(R)-dihydroxy-eicosa-6,8,10(trans/trans/cis), 14(cis)-tetraenoic acid, designated leukotriene B, is generated by the lipoxygenation and subsequent enzymatic hydration of arachidonic acid in a variety of leukocytes. Leukotriene B elicits
Goetzl, EJ, Pickett, WC
core
Reprogramming Immunogenicity of Iron Oxide Nanoparticles through Sulfated Glycan Presentation
Small, EarlyView.This study presents a comparative analysis of heparin (HP)‐ and dextran sulfate (DS)‐coated superparamagnetic iron oxide nanoparticles (SPIONs) as a tunable immunomodulatory platform where surface chemistry dictates therapeutic function. DS‐SPIONs are preferentially internalized by myeloid cells, reprogramming them into a pro‐healing M2 phenotype ...
Negin Pournoori +8 more
wiley +1 more source
C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis
Frontiers in Immunology, 2019 Psoriasis is one of the most common chronic inflammatory skin diseases, affecting ~2% of the population. The lack of characterization of the pathogenesis of psoriasis has hindered efficient clinical treatment of the disease.
Quan-you Zheng +14 more
doaj +1 more source
Specificity and reversibility of chemotactic deactivation of human monocytes [PDF]
, 1981 The chemotactic deactivation of human monocytes was studied to provide insight into the mechanism of chemotaxis. Deactivation was dependent on the dose of chemoattractant and time of incubation.
Falk, Werner, Leonard, E.J.
core +1 more source
Potential Mechanisms Underlying TGF-β-mediated Complement Activation in Lung Fibrosis [PDF]
, 2017 While our previous studies suggest that limiting bleomycin-induced complement activation suppresses TGF-β signaling, the specific hierarchical interactions between TGF-β and complement in lung fibrosis are unclear.
Cipolla, Ellyse +5 more
core +2 more sources