Results 141 to 150 of about 1,253,157 (246)

Protective effects of C5a receptor antagonism in a mouse model of atherosclerosis

, 2008
Inflammation is a major factor in the initiation and progression of atherosclerosis. Complement activation product 5a (C5a) is central to the pathology of many inflammatory diseases, and the C5a receptor (C5aR) antagonist PMX53 has been shown to be ...
Thomas, Anita, Shiels, Ian, Taylor, Steve, Thomas, Anita C, Taylor, Stephen, Manthey, Helga, Rolfe, Barbara, Moore, T, Woodruff, Trent, Moore, Tyson   +9 more
core   +1 more source

ACSL4 Drives C5a/C5aR1–Calcium-Induced Fibroblast-to-Myofibroblast Transition in a Bleomycin-Induced Mouse Model of Pulmonary Fibrosis

Biomolecules
Idiopathic pulmonary fibrosis (IPF) is characterized by excessive extracellular matrix (ECM) deposition driven by aberrant fibroblast-to-myofibroblast transition (FMT).
Tingting Ren, Jia Shi, Lili Zhuang, Ruiting Su, Yimei Lai, Niansheng Yang   +5 more
doaj   +1 more source

A Greater Increase in Complement C5a Receptor 1 Level at Onset and a Smaller Decrease in Immunoglobulin G Level after Recovery in Severer Coronavirus Disease 2019 Patients: A New Analysis of Existing Data with a New Two-Tailed t-Test. [PDF]

Biology (Basel), 2023
Ishida T, Takagi K, Wang G, Tanahashi N, Kawanokuchi J, Takagi H, Guo Y, Ma N.   +7 more
europepmc   +1 more source

Tc-99m-labeled C5a and C5a des Arg74 for infection imaging

, 2003
The complement anaphylatoxin C5a and its natural metabolite C5a des Arg74 (C5adR) are involved in several stages of the inflammatory process. Both act on a common receptor expressed on different cell types, including neutrophils and monocytes.
Boerman, O.C., Corstens, F. H., Boerman, O. C., P.N. Monk, S.A. Cain, H.J. Rennen, Cain, S. A.; id_orcid, Corstens, F.H.M., Monk, P.N., Oyen, W.J.G., Rennen, H.J.J.M., Oyen, W. J., Cain, S.A., Rennen, H. J., F.H. Corstens, W.J. Oyen, O.C. Boerman, Monk, P. N.   +17 more
core   +1 more source

Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis. [PDF]

Mol Ther, 2021
Sommerfeld O, Medyukhina A, Neugebauer S, Ghait M, Ulferts S, Lupp A, König R, Wetzker R, Schulz S, Figge MT, Bauer M, Press AT.   +11 more
europepmc   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene. [PDF]

Noncoding RNA, 2022
Emblem Å, Knutsen E, Jørgensen TE, Fure H, Johansen SD, Brekke OL, Mollnes TE, Karlsen BO.   +7 more
europepmc   +1 more source

Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance

Periodontology 2000, EarlyView.
Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf, Ulrike Schulze‐Späte, Thomas Van Dyke, Stefan Wolfart, Thomas Dietrich, Alberto Ortiz, Zhuojun Wu, Joachim Jankowski   +7 more
wiley   +1 more source

Complement Component C5a and Fungal Pathogen Induce Diverse Responses through Crosstalk between Transient Receptor Potential Channel (TRPs) Subtypes in Human Conjunctival Epithelial Cells

Cells
The conjunctiva has immune-responsive properties to protect the eye from infections. Its innate immune system reacts against external pathogens, such as fungi. The complement factor C5a is an important contributor to the initial immune response.
Loreena Rech, Tina Dietrich-Ntoukas, Peter S. Reinach, Tobias Brockmann, Uwe Pleyer, Stefan Mergler   +5 more
doaj   +1 more source

The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. [PDF]

Nat Commun, 2021
Nording H, Baron L, Haberthür D, Emschermann F, Mezger M, Sauter M, Sauter R, Patzelt J, Knoepp K, Nording A, Meusel M, Meyer-Saraei R, Hlushchuk R, Sedding D, Borst O, Eitel I, Karsten CM, Feil R, Pichler B, Erdmann J, Verschoor A, Chavakis E, Chavakis T, von Hundelshausen P, Köhl J, Gawaz M, Langer HF.   +26 more
europepmc   +1 more source