Results 161 to 170 of about 17,322 (203)
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Inhibiting the C5–C5a receptor axis
Molecular Immunology, 2011Activation of the complement system is a major pathogenic event that drives various inflammatory responses in numerous diseases. All pathways of complement activation lead to cleavage of the C5 molecule generating the anaphylatoxin C5a and, C5b that subsequently forms the terminal complement complex (C5b-9).
Woodruff, Trent M. +2 more
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Human T Cells Express the C5a Receptor and Are Chemoattracted to C5a
The Journal of Immunology, 1999Abstract The anaphylatoxin C5a is a potent mediator of inflammation that exerts a broad range of activity on cells of the myeloid lineage. In this study, we present the first evidence that human T cells express the C5a receptor (C5aR) and are chemotactic to C5a.
S, Nataf +3 more
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Modeling Molecular Mechanisms of Binding of the Anaphylatoxin C5a to the C5a Receptor
Biochemistry, 2008This study presents the 3D model of the complex between the anaphylatoxin C5a and its specific receptor, C5aR. This is the first 3D model of a G-protein-coupled receptor (GPCR) complex with a peptide ligand deduced by a molecular modeling procedure analyzing various conformational possibilities of the extracellular loops and the N-terminal segment of ...
Gregory V, Nikiforovich +2 more
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The chemotactic receptor for human C5a anaphylatoxin
Nature, 1991Host defence and inflammatory responses are controlled and amplified by receptor-mediated events often initiated by a chemotactic factor that directs the approach of phagocytic cells. Complement receptors CR1 and CR3 are responsible for the phagocytic and adhesive properties of neutrophils, whereas the C5a receptor mediates the pro-inflammatory and ...
N P, Gerard, C, Gerard
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Analysis of C5a receptor by monoclonal antibody
Journal of Immunological Methods, 1995We prepared a mouse monoclonal antibody (mAb), termed 4C8, to the human C5a receptor (C5aR, CD88) by fusing spleen cells from mice immunized with mouse Ltk- cells transfected with cDNA of human C5aR (Ltk-/C5aR) to the mouse myeloma cell line P3U1. This mAb belonging to the IgM kappa subclass, detected a 43 kDa band on cell lysates of Ltk-/C5aR by ...
H, Watanabe +5 more
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Distribution of Rat C5a Anaphylatoxin Receptor
Microbiology and Immunology, 2002AbstractThe anaphylatoxin, complement 5a (C5a), plays a key role in mediating various inflammatory reactions following complement activation. Several investigators have reported that C5a receptor (C5aR) is expressed in non‐myeloid cells under certain conditions or in different cell lines.
Hiroyasu, Akatsu +7 more
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The Alternative C5a Receptor Function
2012When acute inflammatory states are induced by treatment with chemical mediators in C5-deficient mice, neutrophil influxes are commonly decreased. Therefore, the neutrophil C5a receptor (C5aR) is believed to be a member of the pro-inflammatory receptors.
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Development of C5a receptor antagonists.
IDrugs : the investigational drugs journal, 1999During host defense, the human complement system of plasma proteins initiates inflammatory and cellular immune responses to stimuli such as infectious organisms, chemical and physical injury, radiation and neoplasia. Elevated levels of one of these plasma proteins C5a, a 74 amino acid peptidic anaphylatoxin which is one of the most potent pro ...
Wong, A., Taylor, S. M., Fairlie, D.
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The Human Mast Cell Line HMC‐1 Expresses C5a Receptors and Responds to C5a but not to C5a(desArg)
Scandinavian Journal of Immunology, 1996The expression of the receptor for the anaphylatoxin C5a (C5aR, CD88) on the human mast cell line HMC‐1 was studied with four anti‐C5aR monoclonal antibodies directed to the N‐terminal domain of the receptor. All antibodies bound to the human mast cell line HMC‐1.
T, Werfel +6 more
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Current pharmaceutical design, 1999
The anaphylatoxin C5a is an extremely potent proinflammatory peptide produced during activation of the complement system. The structure of C5a includes a core region (N-terminal residues 1-63) consisting of four, antiparallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail (residues 64-74).
T C, Pellas, L P, Wennogle
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The anaphylatoxin C5a is an extremely potent proinflammatory peptide produced during activation of the complement system. The structure of C5a includes a core region (N-terminal residues 1-63) consisting of four, antiparallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail (residues 64-74).
T C, Pellas, L P, Wennogle
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