Results 61 to 70 of about 2,358,049 (278)

Cloning and characterization of the guinea pig C5a anaphylatoxin receptor: interspecies diversity among the C5a receptors [PDF]

International Immunology, 1998
The anaphylatoxin C5a receptor (C5aR, CD88 in man) plays a prominent role in mediating inflammatory and host defense processes. Direct evidence of C5aR involvement in host defense mechanisms was demonstrated recently using C5aR knockout mice. Mice deficient in C5aR were unable to clear intrapulmonary-instilled bacteria. The guinea pig system is perhaps
Y, Fukuoka, J A, Ember, A, Yasui, T E, Hugli   +3 more
openaire   +2 more sources

Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis [PDF]

, 2004
Streptococcus uberis and Serratia marcescens are Gram-positive and Gram-negative bacteria, respectively, that induce clinical mastitis. Once initial host barrier systems have been breached by these pathogens, the innate immune system provides the next ...
Bannerman, Douglas D, Goff, Jesse P, Hope, Jayne, Kimura, Kayoko, Lippolis, John D, Paape, Max J   +5 more
core   +3 more sources

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment

mBio, 2018
Sepsis caused by Neisseria meningitidis (meningococcus) is a rapidly progressing, life-threatening disease. Because its initial symptoms are rather unspecific, medical attention is often sought too late, i.e., when the systemic inflammatory response is ...
J. Herrmann, Marcel Muenstermann, Lea Strobel, A. Schubert-Unkmeir, T. Woodruff, S. Gray-Owen, A. Klos, Kay O. Johswich   +7 more
semanticscholar   +1 more source

Enhancement of cancer invasion and growth via the C5a-C5a receptor system: Implications for cancer promotion by autoimmune diseases and association with cervical cancer invasion

Oncology Letters, 2018
Autoimmune diseases are caused by immune complex-induced activation of the complement system and subsequent inflammation. Recent studies have revealed an association between autoimmune diseases and worse survival in patients with cancer; however, the ...
Masakazu Yoneda, Ryuji Imamura, H. Nitta, K. Taniguchi, F. Saito, K. Kikuchi, Hidenao Ogi, Takuya Tanaka, H. Katabuchi, H. Nakayama, T. Imamura   +10 more
semanticscholar   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Above and beyond C5a Receptor Targeting by Staphylococcal Leucotoxins: Retrograde Transport of Panton–Valentine Leucocidin and γ-Hemolysin

Toxins, 2017
Various membrane receptors associated with the innate immune response have recently been identified as mediators of the cellular action of Staphylococcus aureus leucotoxins.
Gaëlle Zimmermann-Meisse, Gilles Prévost, Emmanuel Jover   +2 more
doaj   +1 more source

Leukocyte C5a receptor modulation during hemodialysis

Kidney International, 1987
Exposure of blood to hemodialysis (HD) membranes results in the activation of the complement system. In this study, flow cytometry was used to analyze the binding of fluoresceinated chemotactic factors (C5a, f-Met-Leu-Phe-Lys [fMLPL], and casein) and aggregated IgG to PMN and monocytes isolated from normal whole blood following passage through a ...
Lewis, Sharon L., Van Epps, Dennis E., Chenoweth, Dennis E.   +2 more
openaire   +2 more sources

Functional roles for C5a receptors in sepsis [PDF]

Nature Medicine, 2008
The function of the C5a receptors, C5ar (encoded by C5ar) and C5l2 (encoded by Gpr77), especially of C5l2, which was originally termed a 'default receptor', remains a controversial topic. Here we investigated the role of each receptor in the setting of cecal ligation and puncture-induced sepsis by using antibody-induced blockade of C5a receptors and ...
Daniel, Rittirsch, Michael A, Flierl, Brian A, Nadeau, Danielle E, Day, Markus, Huber-Lang, Charles R, Mackay, Firas S, Zetoune, Norma P, Gerard, Katherine, Cianflone, Jörg, Köhl, Craig, Gerard, J Vidya, Sarma, Peter A, Ward   +12 more
openaire   +2 more sources

C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA

OncoTarget, 2016
Purpose Anaphylatoxin C5a is a strong chemoattractant of the complement system that binds the C5a receptor (C5aR). The expression of C5aR is associated with poor prognosis in several cancers.
T. Kaida, H. Nitta, Y. Kitano, K. Yamamura, K. Arima, Daisuke Izumi, T. Higashi, J. Kurashige, K. Imai, H. Hayashi, M. Iwatsuki, T. Ishimoto, D. Hashimoto, Y. Yamashita, A. Chikamoto, Takahisa Imanura, T. Ishiko, T. Beppu, H. Baba   +18 more
semanticscholar   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source